pH Variation of isotope effects in enzyme-catalyzed reactions. 2. Isotope-dependent step not pH dependent. Kinetic mechanism of alcohol dehydrogenase

[6] Statistical analysis of enzyme kinetic data

1979 • 2,002 citations

Three-dimensional structure of horse liver alcohol dehydrogenase at 2.4 Å resolution

1976 • 691 citations

Evolution of enzyme function and the development of catalytic efficiency

1976 • 604 citations

Studies on Liver Alcohol Dehydrogenase. I. Equilibria and Initial Reaction Velocities.

1951 • 446 citations

Steady-state analysis of kinetic isotope effects in enzymic reactions

1975 • 376 citations

Determining the Chemical Mechanisms of Enzyme‐Catalyzed Reactions by Kinetic Studies

1977 • 340 citations

Studies on Liver Alcohol Dehydrogenase. III. The Influence of pH and Some Anions on the Reaction Velocity Constants.

1955 • 159 citations

Kinetic Studies of Liver Alcohol Dehydrogenase and pH Effects with Coenzyme Preparations of High Purity

1963 • 158 citations

Site‐Specific Substituted Cobalt(II) Horse Liver Alcohol Dehydrogenases

1979 • 145 citations

Mechanistic studies on equine liver alcohol dehydrogenase. I. Stoichiometry relation of the coenzyme binding sites to the catalytic sites active in the reduction of aromatic aldehydes in the transient state

1970 • 139 citations

The Mechanism of Enzyme-catalyzed Reduced Nicotinamide Adenine Dinucleotide-dependent Reductions

1972 • 114 citations

Dissociation constants of the liver alcohol dehydrogenase coenzyme complexes

1959 • 109 citations

Primary and secondary deuterium isotope effects on equilibrium constants for enzyme-catalyzed reactions

1980 • 107 citations

Isotope effects and structure-reactivity correlations in the yeast alcohol dehydrogenase reaction. A study of the enzyme-catalyzed oxidation of aromatic alcohols

1976 • 99 citations

Proton equilibriums and kinetics in the liver alcohol dehydrogenase reaction mechanism

1974 • 93 citations

pH, isotope, and substituent effects on the interconversion of aromatic substrates catalyzed by hydroxybutyrimidylated liver alcohol dehydrogenase

1977 • 90 citations

Equilibrium perturbation by isotope substitution

1975 • 85 citations

Dissociation Constants of the Binary Complex of Homogeneous Horse Liver Alcohol Dehydrogenase and Nicotiniumamide Adenine Dinucleotide.

1967 • 84 citations

Crystallography of liver alcohol dehydrogenase complexed with substrates

1978 • 80 citations

Unified Mechanism for Proton‐Transfer Reactions Affecting the Catalytic Activity of Liver Alcohol Dehydrogenase

1980 • 78 citations

31P NMR studies of enzyme-bound substrates of rabbit muscle pyruvate kinase. Equilibrium constants, exchange rates, and NMR parameters.

1979 • 78 citations

Differentiation of nucleotide binding sites and role of metal ion in the adenylate kinase reaction by 31P NMR. Equilibria, interconversion rates, and NMR parameters of bound substrates

1978 • 77 citations

Substrate activation and inhibition in coenzyme-substrate reactions cyclohexanol oxidation catalysed by liver alcohol dehydrogenase

1966 • 75 citations

31P NMR study of bound reactants and products of yeast 3-phosphoglycerate kinase at equilibrium and the effect of sulfate ion.

1978 • 75 citations

Nuclear magnetic resonance studies of substrate interaction with cobalt substituted alcohol dehydrogenase from liver

1975 • 73 citations

Effect of pH on the Process of Ternary‐Complex Interconversion in the liver‐Alcohol‐Dehydrogenase Reaction

1978 • 71 citations

Rapid kinetic evidence for adduct formation between the substrate analog p-nitroso-N,N-dimethylaniline and reduced nicotinamide adenine dinucleotide during enzymic reduction

1971 • 69 citations

Catalytic steps during the single-turnover reduction of aldehydes by alcohol dehydrogenase

1972 • 69 citations

Roles of zinc ion and reduced coenzyme in horse liver alcohol dehydrogenase catalysis. Mechanism of aldehyde activation

1975 • 64 citations

Transition-state structure in the yeast alcohol dehydrogenase reaction: the magnitude of solvent and .alpha.-secondary hydrogen isotope effects

1980 • 64 citations

Determination of the rate-limiting steps for malic enzyme by the use of isotope effects and other kinetic studies

1977 • 64 citations

Cadmium-113 NMR spectrum of substituted horse liver alcohol dehydrogenase

1980 • 60 citations

Site-site interactions in the liver alcohol dehydrogenase catalytic mechanism

1979 • 54 citations

pH-dependent conformational states of horse liver alcohol dehydrogenase.

1977 • 45 citations

Role of zinc in horse liver alcohol dehydrogenase. II. Coenzyme and substrate binding

1972 • 45 citations

Effect of pH on the Binding of Decanoate and Trifluoroethanol to Liver Alcohol Dehydrogenase

1980 • 45 citations

Liver alcohol dehydrogenase-coenzyme reaction rates.

1977 • 41 citations

The mechanism of quenching of liver alcohol dehydrogenase fluorescence due to ternary complex formation.

1978 • 40 citations

Solvent deuterium isotope effect on the liver alcohol dehydrogenase reaction

1979 • 39 citations

Evidence that hydride transfer precedes proton transfer in the liver alcohol dehydrogenase catalyzed reduction of trans-4-(N,N-dimethylamino)cinnamaldehyde

1980 • 34 citations

Comparison of the kinetics and stoichiometry of proton uptake with aldehyde reduction for liver alcohol dehydrogenase under single turnover conditions

1974 • 33 citations

Role of zinc in horse liver alcohol dehydrogenase. III. Influence on structure and conformational changes

1972 • 33 citations

pH-dependent changes of intrinsic fluorescence of chemically modified liver alcohol dehydrogenases

1978 • 26 citations