Targeted inhibition of p38 MAPK promotes hypertrophic cardiomyopathy through upregulation of calcineurin-NFAT signaling

Prognostic Implications of Echocardiographically Determined Left Ventricular Mass in the Framingham Heart Study

1990 • 5,586 citations

A Calcineurin-Dependent Transcriptional Pathway for Cardiac Hypertrophy

1998 • 2,570 citations

The epidemiology of heart failure: The Framingham Study

1993 • 2,278 citations

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

2001 • 2,027 citations

Organization and regulation of mitogen-activated protein kinase signaling pathways

1999 • 1,288 citations

MKK3- and MKK6-Regulated Gene Expression Is Mediated by the p38 Mitogen-Activated Protein Kinase Signal Transduction Pathway

1996 • 1,286 citations

Left Ventricular Hypertrophy

2000 • 1,197 citations

Cardiac Muscle Cell Hypertrophy and Apoptosis Induced by Distinct Members of the p38 Mitogen-activated Protein Kinase Family

1998 • 855 citations

Cytoplasmic Signaling Pathways That Regulate Cardiac Hypertrophy

2001 • 696 citations

Selective Activation of p38 Mitogen-activated Protein (MAP) Kinase Isoforms by the MAP Kinase Kinases MKK3 and MKK6

1998 • 531 citations

“Stress-Responsive” Mitogen-Activated Protein Kinases (c-Jun N-Terminal Kinases and p38 Mitogen-Activated Protein Kinases) in the Myocardium

1998 • 510 citations

Novel Homologues of CSBP/p38 MAP Kinase: Activation, Substrate Specificity and Sensitivity to Inhibition by Pyridinyl Imidazoles

1997 • 504 citations

Characterization of the Structure and Function of the Fourth Member of p38 Group Mitogen-activated Protein Kinases, p38δ

1997 • 482 citations

Activated glycogen synthase-3β suppresses cardiac hypertrophy in vivo

2002 • 467 citations

Essential role for p38α mitogen-activated protein kinase in placental angiogenesis

2000 • 370 citations

TAK1 is activated in the myocardium after pressure overload and is sufficient to provoke heart failure in transgenic mice

2000 • 340 citations

The in vivo role of p38 MAP kinases in cardiac remodeling and restrictive cardiomyopathy

2001 • 335 citations

Activation of NF-κB is required for hypertrophic growth of primary rat neonatal ventricular cardiomyocytes

2001 • 320 citations

A Role for the p38 Mitogen-activated Protein Kinase Pathway in Myocardial Cell Growth, Sarcomeric Organization, and Cardiac-specific Gene Expression

1997 • 320 citations

Stimulation of the p38 Mitogen-activated Protein Kinase Pathway in Neonatal Rat Ventricular Myocytes by the G Protein–coupled Receptor Agonists, Endothelin-1 and Phenylephrine: A Role in Cardiac Myocyte Hypertrophy?

1998 • 313 citations

Targeted inhibition of calcineurin prevents agonist-induced cardiomyocyte hypertrophy

2000 • 298 citations

Targeted Disruption of NFATc3, but Not NFATc4, Reveals an Intrinsic Defect in Calcineurin-Mediated Cardiac Hypertrophic Growth

2002 • 260 citations

Impaired cardiac hypertrophic response in Calcineurin Aβ -deficient mice

2002 • 240 citations

Opposing Effects of Jun Kinase and p38 Mitogen-Activated Protein Kinases on Cardiomyocyte Hypertrophy

1998 • 234 citations

Calcineurin Promotes Protein Kinase C and c-Jun NH2-terminal Kinase Activation in the Heart

2000 • 232 citations

Mechanical strain activates BNP gene transcription through a p38/NF-κB–dependent mechanism

1999 • 214 citations

Ablation of the murine alpha myosin heavy chain gene leads to dosage effects and functional deficits in the heart.

1996 • 203 citations

Role of the stress-activated protein kinases in endothelin-induced cardiomyocyte hypertrophy.

1998 • 198 citations

Defective T cell development and function incalcineurinAβ-deficient mice

2002 • 182 citations

Activity-dependent nuclear translocation and intranuclear distribution of NFATc in adult skeletal muscle fibers

2001 • 181 citations

Phosphorylation of NFATc4 by p38 Mitogen-Activated Protein Kinases

2002 • 173 citations

The Dual-Specificity Phosphatase MKP-1 Limits the Cardiac Hypertrophic Response In Vitro and In Vivo

2001 • 163 citations

Capacitative Calcium Entry Contributes to Nuclear Factor of Activated T-cells Nuclear Translocation and Hypertrophy in Cardiomyocytes

2002 • 157 citations

Calcineurin Expression, Activation, and Function in Cardiac Pressure-Overload Hypertrophy

2000 • 157 citations

A Role for the p38 MAP Kinase Pathway in the Nuclear Shuttling of NFATp

2000 • 156 citations

Identification of Amino Acid Residues and Protein Kinases Involved in the Regulation of NFATc Subcellular Localization

2000 • 149 citations

Mammalian Mitogen-activated Protein Kinase Pathways Are Regulated through Formation of Specific Kinase-Activator Complexes

1996 • 103 citations

Endothelin-Dependent and -Independent Components of Strain-Activated Brain Natriuretic Peptide Gene Transcription Require Extracellular Signal Regulated Kinase and p38 Mitogen-Activated Protein Kinase

2000 • 98 citations

Decreased p38 MAPK Activity in End-Stage Failing Human Myocardium: p38 MAPK α is the Predominant Isoform Expressed in Human Heart

2001 • 92 citations

Transgenic Remodeling of the Regulatory Myosin Light Chains in the Mammalian Heart

1997 • 89 citations

A Role for the Extracellular Signal-regulated Kinase and p38 Mitogen-activated Protein Kinases in Interleukin-1β-stimulated Delayed Signal Tranducer and Activator of Transcription 3 Activation, Atrial Natriuretic Factor Expression, and Cardiac Myocyte Morphology

2001 • 73 citations

Cardiac Expression and Subcellular Localization of the p38 Mitogen-activated Protein Kinase Member, Stress-activated Protein Kinase-3 (SAPK3)

2002 • 62 citations

Essential Role of p38? MAP Kinase in Placental but Not Embryonic Cardiovascular Development

2000 • 57 citations

The influence of antihypertensive drug treatment on the prevention and regression of left ventricular hypertrophy

2000 • 44 citations