p38 MAPK and NF-κB Collaborate to Induce Interleukin-6 Gene Expression and Release

A simplified system for generating recombinant adenoviruses

1998 • 3,179 citations

An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death

1996 • 3,094 citations

TNF- and Cancer Therapy-Induced Apoptosis: Potentiation by Inhibition of NF-κB

1996 • 2,665 citations

Suppression of TNF-α-Induced Apoptosis by NF-κB

1996 • 2,623 citations

IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation

1997 • 2,048 citations

The IκB Kinase Complex (IKK) Contains Two Kinase Subunits, IKKα and IKKβ, Necessary for IκB Phosphorylation and NF-κB Activation

1997 • 1,802 citations

Identification of a Member of the MAPKKK Family as a Potential Mediator of TGF-β Signal Transduction

1995 • 1,318 citations

MAP3K-related kinase involved in NF-KB induction by TNF, CD95 and IL-1

1997 • 1,294 citations

MKK3- and MKK6-Regulated Gene Expression Is Mediated by the p38 Mitogen-Activated Protein Kinase Signal Transduction Pathway

1996 • 1,286 citations

IκB Kinase-β: NF-κB Activation and Complex Formation with IκB Kinase-α and NIK

1997 • 1,198 citations

Identification and Characterization of an IκB Kinase

1997 • 1,166 citations

The kinase TAK1 can activate the NIK-IκB as well as the MAP kinase cascade in the IL-1 signalling pathway

1999 • 1,163 citations

Site-Specific Phosphorylation of IκBα by a Novel Ubiquitination-Dependent Protein Kinase Activity

1996 • 960 citations

Cardiac Muscle Cell Hypertrophy and Apoptosis Induced by Distinct Members of the p38 Mitogen-activated Protein Kinase Family

1998 • 855 citations

Tumor necrosis factor alpha-induced apoptosis in cardiac myocytes. Involvement of the sphingolipid signaling cascade in cardiac cell death.

1996 • 742 citations

Mapping of the Inducible IκB Phosphorylation Sites That Signal Its Ubiquitination and Degradation†

1996 • 717 citations

p38 and Extracellular Signal-regulated Kinase Mitogen-activated Protein Kinase Pathways Are Required for Nuclear Factor-κB p65 Transactivation Mediated by Tumor Necrosis Factor

1998 • 678 citations

Loss of a gp130 Cardiac Muscle Cell Survival Pathway Is a Critical Event in the Onset of Heart Failure during Biomechanical Stress

1999 • 666 citations

The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis response to tumor necrosis factor.

1996 • 650 citations

Endothelin induction of inositol phospholipid hydrolysis, sarcomere assembly, and cardiac gene expression in ventricular myocytes. A paracrine mechanism for myocardial cell hypertrophy

1990 • 641 citations

The Beginning of the End: IκB Kinase (IKK) and NF-κB Activation

1999 • 635 citations

TAB1: An Activator of the TAK1 MAPKKK in TGF-β Signal Transduction

1996 • 582 citations

Tumor necrosis factor (TNF)-mediated kinase cascades: Bifurcation of Nuclear Factor-κB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2

1997 • 552 citations

Expression cloning of cardiotrophin 1, a cytokine that induces cardiac myocyte hypertrophy.

1995 • 548 citations

Selective Activation of p38 Mitogen-activated Protein (MAP) Kinase Isoforms by the MAP Kinase Kinases MKK3 and MKK6

1998 • 531 citations

Continuous activation of gp130, a signal-transducing receptor component for interleukin 6-related cytokines, causes myocardial hypertrophy in mice.

1995 • 504 citations

Cardiac Release of Cytokines and Inflammatory Responses in Acute Myocardial Infarction

1995 • 499 citations

The p38 Mitogen-activated Protein Kinase Is Required for NF-κB-dependent Gene Expression

1999 • 444 citations

A Novel Kinase Cascade Mediated by Mitogen-activated Protein Kinase Kinase 6 and MKK3

1996 • 443 citations

Tumor necrosis factor-alpha gene and protein expression in adult feline myocardium after endotoxin administration.

1995 • 436 citations

Cardiotrophin 1 (CT-1) Inhibition of Cardiac Myocyte Apoptosis via a Mitogen-activated Protein Kinase-dependent Pathway

1997 • 399 citations

Activation of NF-kappa B in vivo is regulated by multiple phosphorylations.

1994 • 362 citations

Phosphorylation of IκBα Precedes but Is Not Sufficient for Its Dissociation from NF-κB

1995 • 351 citations

TAK1 is activated in the myocardium after pressure overload and is sufficient to provoke heart failure in transgenic mice

2000 • 340 citations

A Role for the p38 Mitogen-activated Protein Kinase Pathway in Myocardial Cell Growth, Sarcomeric Organization, and Cardiac-specific Gene Expression

1997 • 320 citations

Cardiac Myocytes Produce Interleukin-6 in Culture and in Viable Border Zone of Reperfused Infarctions

1999 • 318 citations

Induction of Interleukin-6 Synthesis in the Myocardium

1995 • 298 citations

Hypoxic Stress Induces Cardiac Myocyte–Derived Interleukin-6

1995 • 291 citations

Interleukin-6 Inhibits Apoptosis of Malignant Plasma Cells

1995 • 287 citations

NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain

1997 • 257 citations

Characterization of a transient outward K⁺ current with inward rectification in canine ventricular myocytes

1998 • 256 citations

The Nature of the 660-Kilometer Upper-Mantle Seismic Discontinuity from Precursors to the PP Phase

1996 • 245 citations

Bone Morphogenetic Proteins Induce Cardiomyocyte Differentiation through the Mitogen-Activated Protein Kinase Kinase Kinase TAK1 and Cardiac Transcription Factors Csx/Nkx-2.5 and GATA-4

1999 • 237 citations

An essential role of NFκB in tyrosine kinase signaling of p38 MAP kinase regulation of myocardial adaptation to ischemia

1998 • 232 citations

Interleukin-6 Inhibits Transforming Growth Factor-β-induced Apoptosis through the Phosphatidylinositol 3-Kinase/Akt and Signal Transducers and Activators of Transcription 3 Pathways

1999 • 230 citations

MKK6 Activates Myocardial Cell NF-κB and Inhibits Apoptosis in a p38 Mitogen-activated Protein Kinase-dependent Manner

1998 • 227 citations

Functional Interactions of Transforming Growth Factor β-activated Kinase 1 with IκB Kinases to Stimulate NF-κB Activation

1999 • 218 citations

Activation of Phosphatidylinositol 3-Kinase through Glycoprotein 130 Induces Protein Kinase B and p70 S6 Kinase Phosphorylation in Cardiac Myocytes

1998 • 211 citations

p38-2, a Novel Mitogen-activated Protein Kinase with Distinct Properties

1997 • 176 citations

A possible role of sphingosine in induction of apoptosis by tumor necrosis factor‐α, in human neutrophils

1994 • 168 citations

Induction of Jak/STAT Signaling by Activation of the Type 1 TNF Receptor

1998 • 166 citations

Transactivation Domain 2 (TA2) of p65 NF-κB

1995 • 161 citations

Identification of c-Jun NH2-terminal Protein Kinase (JNK)-activating Kinase 2 as an Activator of JNK but Not p38

1997 • 120 citations

Cardiotrophin-1: a multifunctional cytokine that signals via LIF receptor gp130 dependent pathways

1996 • 110 citations

Stress activated cytokines and the heart

1996 • 104 citations

Involvement of Multiple cis Elements in Basal- and α-Adrenergic Agonist–Inducible Atrial Natriuretic Factor Transcription

1995 • 104 citations

Leukemia inhibitory factor and tumor necrosis factor induce manganese superoxide dismutase and protect rabbit hearts from reperfusion injury

1995 • 90 citations

Acute inflammatory reaction after myocardial ischemic injury and reperfusion. Development and use of a neutrophil-specific antibody.

1996 • 79 citations

Tissue-Specific Expression of the Human Brain Natriuretic Peptide Gene in Cardiac Myocytes

1996 • 74 citations

Intracellular Signaling in Rat Cultured Vascular Smooth Muscle Cells: Roles of Nuclear Factor-κB and p38 Mitogen-Activated Protein Kinase on Tumor Necrosis Factor-α Production*

1999 • 63 citations

Endothelin‐1 induces expression of fetal genes through the interleukin‐6 family of cytokines in cardiac myocytes

1999 • 31 citations

Expression of mitogen-activated protein kinase pathways during postnatal development of rat heart

1998 • 22 citations

Interleukin-6 secreted from human myxoma reduces murine viral myocarditis

1996 • 11 citations

Role of sphingosine in induced apoptosis

1999 • 10 citations