Essential Role of Gab1 for Signaling by the C-Met Receptor in Vivo

Manipulating the mouse embryo: A laboratory manual

1986 • 4,548 citations

Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity

1993 • 2,146 citations

Disruption of IRS-2 causes type 2 diabetes in mice

1998 • 1,766 citations

Growth factor signaling by receptor tyrosine kinases

1992 • 1,450 citations

Scatter factor/hepatocyte growth factor is essential for liver development

1995 • 1,398 citations

Scatter factor is a fibroblast-derived modulator of epithelial cell mobility

1987 • 1,333 citations

Receptor Protein-Tyrosine Kinases and Their Signal Transduction Pathways

1994 • 1,309 citations

Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud

1995 • 1,278 citations

LAT

1998 • 1,251 citations

In situ hybridization; a practical approach

1993 • 1,247 citations

Identification of a fibroblast-derived epithelial morphogen as hepatocyte growth factor

1991 • 1,176 citations

Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor

1995 • 1,039 citations

A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family

1994 • 983 citations

A Lipid-Anchored Grb2-Binding Protein That Links FGF-Receptor Activation to the Ras/MAPK Signaling Pathway

1997 • 861 citations

Scatter factor: molecular characteristics and effect on the invasiveness of epithelial cells.

1990 • 695 citations

A Grb2-associated docking protein in EGF- and insulin-receptor signalling

1996 • 674 citations

Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis

1996 • 572 citations

Mechanism of met oncogene activation

1986 • 551 citations

Regulation of Scatter Factor/Hepatocyte Growth Factor Responses by Ras, Rac, and Rho in MDCK Cells

1995 • 547 citations

Limb-somite relationship: origin of the limb musculature

1977 • 528 citations

Irs-2 coordinates Igf-1 receptor-mediated β-cell development and peripheral insulin signalling

1999 • 526 citations

Experimental analysis of the origin of the wing musculature in avian embryos

1977 • 520 citations

A targeted mutation in the mouse E-cadherin gene results in defective preimplantation development.

1995 • 498 citations

Expression of the Met/HGF receptor in normal and neoplastic human tissues.

1991 • 481 citations

Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2

1997 • 474 citations

Eph receptors and ephrins: effectors of morphogenesis

1999 • 445 citations

Diverse tumorigenesis associated with aberrant development in mice overexpressing hepatocyte growth factor/scatter factor

1997 • 444 citations

Activating mutations for the Met tyrosine kinase receptor in human cancer

1997 • 441 citations

The Met receptor tyrosine kinase transduces motility, proliferation, and morphogenic signals of scatter factor/hepatocyte growth factor in epithelial cells.

1993 • 409 citations

The glial cells missing-1 protein is essential for branching morphogenesis in the chorioallantoic placenta

2000 • 408 citations

Protein-tyrosine Phosphatase Shp-2 Regulates Cell Spreading, Migration, and Focal Adhesion

1998 • 390 citations

p62 : A Constitutively Tyrosine-Phosphorylated, GAP-Associated Protein in Chronic Myelogenous Leukemia Progenitor Cells

1997 • 371 citations

Pax3 modulates expression of the c-Met receptor during limb muscle development.

1996 • 359 citations

A Novel Positive Feedback Loop Mediated by the Docking Protein Gab1 and Phosphatidylinositol 3-Kinase in Epidermal Growth Factor Receptor Signaling

2000 • 350 citations

Identification of the Abl- and rasGAP-Associated 62 kDa Protein as a Docking Protein, Dok

1997 • 350 citations

Coupling of Gab1 to C-Met, Grb2, and Shp2 Mediates Biological Responses

2000 • 333 citations

The role of SF/HGF and c-Met in the development of skeletal muscle

1999 • 322 citations

Cloning of p97/Gab2, the Major SHP2-Binding Protein in Hematopoietic Cells, Reveals a Novel Pathway for Cytokine-Induced Gene Activation

1998 • 313 citations

Uncoupling of Grb2 from the Met Receptor In Vivo Reveals Complex Roles in Muscle Development

1996 • 309 citations

Coordinate expression of vascular endothelial growth factor receptor‐1 (fit‐1) and its ligand suggests a paracrine regulation of murine vascular development

1995 • 288 citations

Gab1 Acts as an Adapter Molecule Linking the Cytokine Receptor gp130 to ERK Mitogen-Activated Protein Kinase

1998 • 287 citations

Trisomy 7-harbouring non-random duplication of the mutant MET allele in hereditary papillary renal carcinomas

1998 • 285 citations

Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factor

1997 • 276 citations

Placental failure in mice lacking the homeobox gene Dlx 3

1999 • 256 citations

Multiple Requirements for SHPTP2 in Epidermal Growth Factor-Mediated Cell Cycle Progression

1996 • 247 citations

Hepatocyte growth factor--scatter factor: mitogen, motogen, and met.

1991 • 234 citations

Molecular Aspects of Mesenchymal-Epithelial Interactions

1993 • 232 citations

How is myogenesis initiated in the embryo?

1996 • 231 citations

Neuregulins in Development

1996 • 229 citations

Roles for PDGF-A and sonic hedgehog in development of mesenchymal components of the hair follicle

1999 • 228 citations

The role of Lbx1 in migration of muscle precursor cells

2000 • 222 citations

The c-ros tyrosine kinase receptor controls regionalization and differentiation of epithelial cells in the epididymis.

1996 • 218 citations

Phosphoinositide 3-Kinase Induces Scattering and Tubulogenesis in Epithelial Cells through a Novel Pathway

1998 • 216 citations

Pax-3 is necessary for migration but not differentiation of limb muscle precursors in the mouse

1996 • 215 citations

Daughter of Sevenless Is a Substrate of the Phosphotyrosine Phosphatase Corkscrew and Functions during Sevenless Signaling

1996 • 210 citations

Specification of the hypaxial musculature

1998 • 207 citations

The Gab1 PH Domain Is Required for Localization of Gab1 at Sites of Cell-Cell Contact and Epithelial Morphogenesis Downstream from the Met Receptor Tyrosine Kinase

1999 • 194 citations

Two North American Families With Hereditary Papillary Renal Carcinoma and Identical Novel Mutations in the MET Proto-Oncogene

1999 • 184 citations

The motogenic and mitogenic responses to HGF are amplified by the Shc adaptor protein.

1995 • 180 citations

DOS, a Novel Pleckstrin Homology Domain–Containing Protein Required for Signal Transduction between Sevenless and Ras1 in Drosophila

1996 • 180 citations

The motility signal of scatter factor/hepatocyte growth factor mediated through the receptor tyrosine kinase met requires intracellular action of Ras.

1994 • 175 citations

Hepatocyte growth factor/scatter factor overexpression induces growth, abnormal development, and tumor formation in transgenic mouse livers.

1996 • 150 citations

Mouse Lbx1 and human LBX1 define a novel mammalian homeo☐ gene family related to the Drosophila lady bird genes

1995 • 147 citations

Signaling of Hepatocyte Growth Factor/Scatter Factor (HGF) to the Small GTPase Rap1 via the Large Docking Protein Gab1 and the Adapter Protein CRKL

2000 • 141 citations

Expression of the met receptor tyrosine kinase in muscle progenitor cells in somites and limbs is absent in Splotch mice

1996 • 140 citations

Involvement of hepatocyte growth factor/scatter factor and Met receptor signaling in hair follicle morphogenesis and cycling

2000 • 138 citations

Tyrosine 1356 in the carboxyl-terminal tail of the HGF/SF receptor is essential for the transduction of signals for cell motility and morphogenesis.

1994 • 130 citations

Biased Suppression of Hematopoiesis and Multiple Developmental Defects in Chimeric Mice Containing Shp-2 Mutant Cells

1998 • 130 citations

Gab1 coupling to the HGF/Met receptor multifunctional docking site requires binding of Grb2 and correlates with the transforming potential

1997 • 128 citations

PDGFB Regulates the Development of the Labyrinthine Layer of the Mouse Fetal Placenta

1999 • 124 citations

Role of morphogenetic factors in metastasis of mammary carcinoma cells

1998 • 122 citations

Pax-3 is necessary but not sufficient for lbx1 expression in myogenic precursor cells of the limb

1998 • 119 citations

Autocrine hepatocyte growth factor/scatter factor-Met signaling induces transformation and the invasive/metastastic phenotype in C127 cells.

1996 • 114 citations

Erythropoietin Induces the Tyrosine Phosphorylation of GAB1 and Its Association With SHC, SHP2, SHIP, and Phosphatidylinositol 3-Kinase

1999 • 113 citations

Tyrosine Phosphorylation of Insulin Receptor Substrate-1 in Vivo Depends upon the Presence of Its Pleckstrin Homology Region

1995 • 113 citations

Mutation of juxtamembrane tyrosine residue 1001 suppresses loss-of-function mutations of the met receptor in epithelial cells.

1995 • 107 citations

Motogenic and morphogenic activity of epithelial receptor tyrosine kinases.

1996 • 100 citations

The Gab1 Protein Is a Docking Site for Multiple Proteins Involved in Signaling by the B Cell Antigen Receptor

1998 • 93 citations

A point mutation in the MET oncogene abrogates metastasis without affecting transformation

1997 • 92 citations

Morphogenetic movements at gastrulation require the SH2 tyrosine phosphatase Shp2

1999 • 90 citations

Local Injection of Hepatocyte Growth Factor/Scatter Factor (HGF/SF) Alters Cyclic Growth of Murine Hair Follicles

1998 • 84 citations

Efficient cell transformation by the Tpr-Met oncoprotein is dependent upon tyrosine 489 in the carboxy-terminus.

1995 • 68 citations

III. Role of the RET signal transduction pathway in development of the mammalian enteric nervous system

1998 • 34 citations

Molecular Aspects of Epithelial-Mesenchymal Interactions

1993 • 27 citations