Preformed CD40 ligand exists in secretory lysosomes in effector and memory CD4+ T cells and is quickly expressed on the cell surface in an antigen-specific manner

T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases

2004 • 1,657 citations

Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation

2003 • 1,563 citations

Follicular B Helper T Cells Express Cxc Chemokine Receptor 5, Localize to B Cell Follicles, and Support Immunoglobulin Production

2000 • 1,379 citations

CD40-CD40 ligand

2000 • 1,376 citations

Imaging of Germinal Center Selection Events During Affinity Maturation

2006 • 760 citations

CD40/CD154 Interactions at the Interface of Tolerance and Immunity

2004 • 673 citations

Naive T Cells Transiently Acquire a Memory-like Phenotype during Homeostasis-Driven Proliferation

2000 • 644 citations

Secretory lysosomes

2002 • 633 citations

Differential regulation of antiviral T-cell immunity results in stable CD8+ but declining CD4+ T-cell memory

2001 • 600 citations

Intracellular Trafficking of CTLA-4 and Focal Localization Towards Sites of TCR Engagement

1996 • 583 citations

Antigen-Engaged B Cells Undergo Chemotaxis toward the T Zone and Form Motile Conjugates with Helper T Cells

2005 • 561 citations

Imaging the Single Cell Dynamics of CD4+ T Cell Activation by Dendritic Cells in Lymph Nodes

2004 • 537 citations

Cytotoxic T Lymphocyte Antigen-4 Accumulation in the Immunological Synapse Is Regulated by TCR Signal Strength

2002 • 497 citations

Cutting Edge: Naive T Cells Masquerading as Memory Cells

2000 • 476 citations

Interpreting flow cytometry data: a guide for the perplexed

2006 • 469 citations

Direct access to CD4+ T cells specific for defined antigens according to CD154 expression

2005 • 457 citations

T cells use two directionally distinct pathways for cytokine secretion

2006 • 410 citations

Degranulation plays an essential part in regulating cell surface expression of Fas ligand in T cells and natural killer cells

1999 • 385 citations

Control of T Cell Viability

2004 • 367 citations

Stable T cell–dendritic cell interactions precede the development of both tolerance and immunity in vivo

2005 • 322 citations

A live-cell assay to detect antigen-specific CD4+ T cells with diverse cytokine profiles

2005 • 306 citations

Cell Biology of Cytotoxic and Helper T Cell Functions: Immunofluorescence Microscopic Studies of Single Cells and Cell Couples

1989 • 296 citations

The targeting of Lamp1 to lysosomes is dependent on the spacing of its cytoplasmic tail tyrosine sorting motif relative to the membrane.

1996 • 258 citations

Secretory cytotoxic granule maturation and exocytosis require the effector protein hMunc13-4

2007 • 256 citations

A soluble form of TRAP (CD40 ligand) is rapidly released after T cell activation

1995 • 252 citations

NK Markers Are Expressed on a High Percentage of Virus-Specific CD8+ and CD4+ T Cells

2000 • 250 citations

A subset of CD4+ memory T cells contains preformed CD40 ligand that is rapidly but transiently expressed on their surface after activation through the T cell receptor complex.

1995 • 231 citations

Studies on the interdependence of gp39 and B7 expression and function during antigen‐specific immune responses

1995 • 225 citations

CD40 molecules induce down-modulation and endocytosis of T cell surface T cell-B cell activating molecule/CD40-L. Potential role in regulating helper effector function.

1994 • 205 citations

Functional CD40 ligand is expressed by T cells in rheumatoid arthritis.

1997 • 166 citations

B cells regulate expression of CD40 ligand on activated T cells by lowering the mRNA level and through the release of soluble CD40

1994 • 157 citations

The CD40/CD40L costimulatory pathway in inflammatory bowel disease

2004 • 155 citations

Regulation of Cell Surface Expression of CTLA-4 by Secretion of CTLA-4-Containing Lysosomes Upon Activation of CD4+ T Cells

2000 • 146 citations

Separable effector T cell populations specialized for B cell help or tissue inflammation

2001 • 138 citations

Human CD8+ T Cells Store RANTES in a Unique Secretory Compartment and Release It Rapidly after TcR Stimulation

2004 • 105 citations

Peptide-Specific Intercellular Transfer of MHC Class II to CD4+ T Cells Directly from the Immunological Synapse upon Cellular Dissociation

2005 • 101 citations

CD40 Ligand Binds to α5β1 Integrin and Triggers Cell Signaling

2006 • 101 citations

The Biological Outcome of CD40 Signaling Is Dependent on the Duration of CD40 Ligand Expression

2002 • 98 citations

Clustering of CD40 Ligand Is Required to Form a Functional Contact with CD40

2002 • 93 citations

CD40-CD40 Ligand Interaction between Dendritic Cells and CD8+ T Cells Is Needed to Stimulate Maximal T Cell Responses in the Absence of CD4+ T Cell Help

2007 • 90 citations

Naive CD4 T cells constitutively express CD40L and augment autoreactive B cell survival

2006 • 89 citations

A Signal through OX40 (CD134) Allows Anergic, Autoreactive T Cells to Acquire Effector Cell Functions

2004 • 87 citations

Immunological Synapse Formation Licenses CD40-CD40L Accumulations at T-APC Contact Sites

2004 • 63 citations

Structure and duration of contact between dendritic cells and T cells are controlled by T cell activation state

2006 • 60 citations

Down-Regulation of Cell Surface Receptors Is Modulated by Polar Residues within the Transmembrane Domain

2000 • 54 citations

Sustained Expression of CD154 (CD40L) and Proinflammatory Cytokine Production by Alloantigen-Stimulated Umbilical Cord Blood T Cells

2000 • 53 citations

Differential regulation of virus-specific T-cell effector functions following activation by peptide or innate cytokines

2004 • 50 citations

Functional CD40 ligand expression on T lymphocytes in the absence of T cell receptor engagement: involvement in interleukin‐2‐induced interleukin‐12 and interferon‐γ production

1996 • 50 citations

CD4+ T Lymphocytes with Constitutive CD40 Ligand in Preautoimmune (NZB × NZW)F1 Lupus-Prone Mice: Phenotype and Possible Role in Autoreactivity

2000 • 32 citations

Isolation of viable antigen-specific CD4 T cells by CD40L surface trapping

2005 • 24 citations

Intracellular Protein Traffic in Lymphocytes

1999 • 17 citations

Cyclooxygenase Regulates Cell Surface Expression of CXCR3/1-Storing Granules in Human CD4+ T Cells

2006 • 14 citations

Multiple cytokines sharing the common receptor γ chain can induce CD154/CD40 ligand expression by human CD4⁺ T lymphocytes via a cyclosporin A‐resistant pathway

2001 • 10 citations