Differential regulation of virus-specific T-cell effector functions following activation by peptide or innate cytokines

A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation

1986 • 4,200 citations

Interleukin-12 and the regulation of innate resistance and adaptive immunity

2003 • 3,689 citations

Interleukin-2: Inception, Impact, and Implications

1988 • 2,166 citations

Counting Antigen-Specific CD8 T Cells: A Reevaluation of Bystander Activation during Viral Infection

1998 • 1,996 citations

Lineage relationship and protective immunity of memory CD8 T cell subsets

2003 • 1,833 citations

Identification of a common nucleotide sequence in the 3'-untranslated region of mRNA molecules specifying inflammatory mediators.

1986 • 1,591 citations

Viral Persistence Alters CD8 T-Cell Immunodominance and Tissue Distribution and Results in Distinct Stages of Functional Impairment

2003 • 1,500 citations

Impaired On/Off Regulation of TNF Biosynthesis in Mice Lacking TNF AU-Rich Elements

1999 • 1,325 citations

Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice

1996 • 1,277 citations

Partners in transcription: NFAT and AP-1

2001 • 757 citations

IGIF Does Not Drive Th1 Development but Synergizes with IL-12 for Interferon-γ Production and Activates IRAK and NFκB

1997 • 726 citations

The Interleukin-1 Receptor/Toll-Like Receptor Superfamily: Signal Transduction During Inflammation and Host Defense

2003 • 696 citations

Suppressors of cytokine signalling (SOCS) in the immune system

2002 • 633 citations

A Role for CD40 Expression on CD8 ⁺ T Cells in the Generation of CD8 ⁺ T Cell Memory

2002 • 629 citations

Toll receptors, CD14, and macrophage activation and deactivation by LPS

2002 • 557 citations

Interaction of NF-κB and NFAT with the Interferon-γ Promoter

1997 • 427 citations

Clinical implications of dysregulated cytokine production

2000 • 407 citations

Continuous T cell receptor signaling required for synapse maintenance and full effector potential

2003 • 405 citations

Therapeutic use of IL-2 to enhance antiviral T-cell responses in vivo

2003 • 384 citations

Memory CD8+ T Cells Provide Innate Immune Protection against Listeria monocytogenes in the Absence of Cognate Antigen

2003 • 326 citations

Degradation of T Cell Receptor (TCR)–CD3-ζ Complexes after Antigenic Stimulation

1997 • 316 citations

Interleukin‐18 and Host Defense against Infection

2003 • 290 citations

Bystander Activation of CD8+ T Cells Contributes to the Rapid Production of IFN-γ in Response to Bacterial Pathogens

2001 • 284 citations

Adaptors as central mediators of signal transduction in immune cells

2003 • 267 citations

Ablation of CD8 and CD4 T Cell Responses by High Viral Loads

2003 • 266 citations

Rapid on/off cycling of cytokine production by virus-specific CD8+ T cells

1999 • 259 citations

AU-rich element-mediated translational control: complexity and multiple activities of trans-activating factors

2002 • 214 citations

Sustained and dynamic inositol lipid metabolism inside and outside the immunological synapse

2002 • 212 citations

Transcriptional induction by interferon. New protein(s) determine the extent and length of the induction.

1986 • 204 citations

The role of programming in memory T-cell development

2004 • 195 citations

It's all Rel-ative: NF-κB and CD28 costimulation of T-cell activation

2002 • 183 citations

The CD40–CD154 interaction in B cell–T cell liaisons

2003 • 181 citations

How do viral infections predispose patients to bacterial infections?

2004 • 180 citations

Activated and Memory CD8+ T Cells Can Be Distinguished by Their Cytokine Profiles and Phenotypic Markers

2000 • 174 citations

Endogenous IL-2 contributes to T cell expansion and IFN-gamma production during lymphocytic choriomeningitis virus infection.

1995 • 172 citations

Contribution of CD8+ T cells to innate immunity: IFN-γ secretion induced by IL-12 and IL-18

2002 • 168 citations

CD40-CD40 Ligand Costimulation Is Required for Generating Antiviral CD4 T Cell Responses But Is Dispensable for CD8 T Cell Responses

1999 • 153 citations

Memory CD8+ T Cells Provide an Early Source of IFN-γ

2003 • 141 citations

The CD40L Promoter Contains Nuclear Factor of Activated T Cells-binding Motifs Which Require AP-1 Binding for Activation of Transcription

1996 • 119 citations

Antigen-Specific Regulation of T Cell–Mediated Cytokine Production

2000 • 110 citations

An IFN-γ-Dependent Pathway Controls Stimulation of Memory Phenotype CD8+ T Cell Turnover In Vivo by IL-12, IL-18, and IFN-γ

2001 • 106 citations

CD4+ and CD8+ T cell interactions in IFN-gamma and IL-4 responses to viral infections: requirements for IL-2.

1998 • 97 citations

Feedback regulation of lymphocyte signalling

2004 • 89 citations

A Signal through OX40 (CD134) Allows Anergic, Autoreactive T Cells to Acquire Effector Cell Functions

2004 • 87 citations

CD4+ and CD8+ T Cell Interactions in IFN-γ and IL-4 Responses to Viral Infections: Requirements for IL-2

1998 • 85 citations

Synergism for cytokine-mediated disease during concurrent endotoxin and viral challenges: roles for NK and T cell IFN-gamma production.

1999 • 82 citations

Signal extinction and T cell repolarization in T helper cell‐antigen‐presenting cell conjugates

1996 • 76 citations

Long-range transcriptional regulation of cytokine gene expression

1998 • 71 citations

Synergism for Cytokine-Mediated Disease During Concurrent Endotoxin and Viral Challenges: Roles for NK and T Cell IFN-γ Production

1999 • 69 citations

The Rapidity with Which Virus-Specific CD8+ T Cells Initiate IFN-γ Synthesis Increases Markedly over the Course of Infection and Correlates with Immunodominance

2004 • 57 citations

Two Overlapping Subdominant Epitopes Identified by DNA Immunization Induce Protective CD8⁺T-Cell Populations with Differing Cytolytic Activities

2001 • 48 citations

Cutting Edge: OFF Cycling of TNF Production by Antigen-Specific CD8+ T Cells Is Antigen Independent

2000 • 46 citations

The Regulation and Maturation of Antiviral Immune Responses

2004 • 22 citations