p21H-ras-induced morphological transformation and increases in c-myc expression are independent of functional protein kinase C.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.

1980 • 8,711 citations

Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor

1983 • 2,350 citations

Early Signals in the Mitogenic Response

1986 • 1,498 citations

A Cytoplasmic Protein Stimulates Normal N- ras p21 GTPase, But Does Not Affect Oncogenic Mutants

1987 • 1,197 citations

Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells

1985 • 913 citations

The ras gene family and human carcinogenesis

1988 • 786 citations

Induction of Membrane Ruffling and Fluid-Phase Pinocytosis in Quiescent Fibroblasts by ras Proteins

1986 • 725 citations

Comparative biochemical properties of normal and activated human ras p21 protein

1984 • 713 citations

A c-myc antisense oligodeoxynucleotide inhibits entry into S phase but not progress from G0 to G1

1987 • 696 citations

Cloning of bovine GAP and its interaction with oncogenic ras p21

1988 • 666 citations

Guanosine Triphosphatase Activating Protein (GAP) Interacts with the p21 ras Effector Binding Domain

1988 • 533 citations

Ras -Transformed Cells: Altered Levels of Phosphatidylinositol-4,5-Bisphosphate and Catabolites

1986 • 450 citations

Normal p21N-ras couples bombesin and other growth factor receptors to inositol phosphate production

1986 • 406 citations

The cytoplasmic protein GAP is implicated as the target for regulation by the ras gene product

1988 • 402 citations

Microinjection of the oncogene form of the human H-ras (t-24) protein results in rapid proliferation of quiescent cells

1984 • 401 citations

Transformation of NIH 3T3 cells by microinjection of Ha-ras p21 protein

1984 • 379 citations

Cellular ras activity and phospholipid metabolism

1988 • 331 citations

c-myc gene expression is stimulated by agents that activate protein kinase C and does not account for the mitogenic effect of PDGF

1985 • 331 citations

Elevated levels of diacylglycerol and decreased phorbol ester sensitivity in ras-transformed fibroblasts

1987 • 330 citations

A method for incorporating macromolecules into adherent cells.

1984 • 307 citations

Novel source of 1,2-diacylglycerol elevated in cells transformed by Ha-ras oncogene

1987 • 303 citations

Primary structure of the α-subunit of transducin and its relationship to ras proteins

1985 • 291 citations

Identification of effector residues and a neutralizing epitope of Ha-ras-encoded p21.

1986 • 291 citations

Mutational analysis of a ras catalytic domain.

1986 • 205 citations

Glass beads load macromolecules into living cells

1987 • 181 citations

Binding of phorbol esters to high‐affinity sites on murine fibroblastic cells elicits a mitogenic response

1982 • 167 citations

[30] Microinjection of tissue culture cells

1983 • 160 citations

Deregulation of hamster fibroblast proliferation by mutated ras oncogenes is not mediated by constitutive activation of phosphoinositide-specific phospholipase C.

1988 • 143 citations

Involvement of functional protein kinase C in the mitogenic response to the H-ras oncogene product.

1987 • 131 citations

Microinjection of Transforming ras protein induces c-fos Expression

1987 • 123 citations

Biochemical and biological properties of the human N-ras p21 protein.

1987 • 106 citations

Scrape-loading of Swiss 3T3 cells with ras protein rapidly activates protein kinase C in the absence of phosphoinositide hydrolysis.

1989 • 103 citations

Mutant but not normal p21 ras elevates inositol phospholipid breakdown in two different cell systems.

1988 • 53 citations

Mutational Analysis of a ras Catalytic Domain

1986 • 36 citations

Immunocytochemical localization in normal and transformed human cells in tissue culture using a monoclonal antibody to the src protein of the Harvey strain of Murine Sarcoma Virus

1983 • 28 citations