Enhancement of inositol phospholipid metabolism and activation of protein kinase C in ras-transformed rat fibroblasts.

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides

1983 • 1,937 citations

Prevalence of ras gene mutations in human colorectal cancers

1987 • 1,866 citations

Phorbol esters increase the amount of Ca2+, phospholipid-dependent protein kinase associated with plasma membrane

1983 • 1,304 citations

Detection of high incidence of K-ras oncogenes during human colon tumorigenesis

1987 • 1,074 citations

Quantitative measurement of sn-1,2-diacylglycerols present in platelets, hepatocytes, and ras- and sis-transformed normal rat kidney cells.

1986 • 999 citations

Direct mutagenesis of Ha-ras-1 oncogenes by N-nitroso-N-methylurea during initiation of mammary carcinogenesis in rats

1985 • 829 citations

Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity

1987 • 670 citations

Protein kinase C activation by diacylglycerol second messengers

1986 • 498 citations

Ras -Transformed Cells: Altered Levels of Phosphatidylinositol-4,5-Bisphosphate and Catabolites

1986 • 450 citations

Decrease in cytosolic calcium/phospholipid-dependent protein kinase activity following phorbol ester treatment of EL4 thymoma cells.

1982 • 417 citations

Rapid formation of diacylglycerol from phosphatidylcholine: a pathway for generation of a second messenger.

1986 • 415 citations

Normal p21N-ras couples bombesin and other growth factor receptors to inositol phosphate production

1986 • 406 citations

Dual evolutionary origin for the rat genetic sequences of Harvey murine sarcoma virus

1980 • 387 citations

Elevated levels of diacylglycerol and decreased phorbol ester sensitivity in ras-transformed fibroblasts

1987 • 330 citations

Protein kinase C phosphorylation at Thr 654 of the unoccupied EGF receptor and EGF binding regulate functional receptor loss by independent mechanisms

1986 • 325 citations

Purification of polyphosphoinositides by chromatography on immobilized neomycin.

1978 • 323 citations

Novel source of 1,2-diacylglycerol elevated in cells transformed by Ha-ras oncogene

1987 • 303 citations

Protein kinase C directly phosphorylates the insulin receptor in vitro and reduces its protein-tyrosine kinase activity.

1986 • 275 citations

Epidermal growth factor stimulates the production of phosphatidylinositol monophosphate and the breakdown of polyphosphoinositides in A431 cells.

1987 • 230 citations

Mutational analysis of a ras catalytic domain.

1986 • 205 citations

Epidermal growth factor stimulates the rapid accumulation of inositol (1,4,5)-trisphosphate and a rise in cytosolic calcium mobilized from intracellular stores in A431 cells.

1987 • 202 citations

Insulin Rapidly Increases Diacylglycerol by Activating De Novo Phosphatidic Acid Synthesis

1987 • 200 citations

Down regulation of phorbol diester receptors by proteolytic degradation of protein kinase C in a cultured cell line of fetal rat skin keratinocytes.

1986 • 183 citations

The effects of bombesin on polyphosphoinositide and calcium metabolism in Swiss 3T3 cells.

1987 • 175 citations

A guanine nucleotide-dependent phosphatidylinositol 4,5-diphosphate phospholipase C in cells transformed by the v-fms and v-fes oncogenes.

1986 • 168 citations

Transformation of mammalian cells by avian myelocytomatosis virus and avian erythroblastosis virus

1979 • 166 citations

Inhibitory effect of prostaglandin E2, forskolin, and dibutyryl cAMP on arachidonic acid release and inositol phospholipid metabolism in guinea pig neutrophils.

1986 • 164 citations

Diacylglycerol kinase from pig brain. Purification and phospholipid dependencies.

1983 • 135 citations

Rapid Stimulation of Diacylglycerol Production in Xenopus Oocytes by Microinjection of H- ras p21

1987 • 134 citations

Isolation of transforming sequences of two human lung carcinomas: structural and functional analysis of the activated c-K-ras oncogenes.

1984 • 132 citations

Phorbol ester- and protein kinase C-mediated phosphorylation of the cellular Kirsten ras gene product.

1987 • 128 citations

Protein kinase C in fibroblasts. Characteristics of its intracellular location during growth and after exposure to phorbol esters and other mitogens.

1987 • 127 citations

Opposing effects of a ras oncogene on growth factor-stimulated phosphoinositide hydrolysis: desensitization to platelet-derived growth factor and enhanced sensitivity to bradykinin.

1987 • 125 citations

Ras p21 proteins with high or low GTPase activity can efficiently transform NIH3T3 cells

1986 • 118 citations

Isolation and characterization of two different forms of inositol phospholipid-specific phospholipase C from rat brain.

1988 • 108 citations

Altered signal transduction in erbB-transformed cells. Implication of enhanced inositol phospholipid metabolism in erbB-induced transformation.

1987 • 62 citations

Activation of ras p21 transforming properties associated with an increase in the release rate of bound guanine nucleotide.

1986 • 53 citations

Growth signal transduction: Rapid activation of covalently bound ornithine decarboxylase during phosphatidylinositol breakdown

1987 • 53 citations

Loss of mouse fibroblast cell response to phorbol esters restored by microinjected protein kinase C

1986 • 50 citations

Activation of protein kinase C and specific phosphorylation of a Mr 90,000 membrane protein of promotable BALB/3T3 and C3H/10T1/2 cells by tumor promoters.

1986 • 43 citations

Presence of specific binding sites for phorbol ester tumor promoters in human epidermal and dermal cells in culture but lack of down regulation in epidermal cells.

1983 • 32 citations

Epidermal growth factor stimulates diacylglycerol kinase in isolated plasma membrane vesicles from A431 cells

1985 • 27 citations

G proteins and diabetes

1987 • 24 citations

Quantitation of adenosine-5'-triphosphate used for phosphoinositide metabolism in human erythrocytes

1985 • 12 citations