Spontaneous Expression of Inducible Nitric Oxide Synthase in the Hypothalamus and Other Brain Regions of Aging Rats¹

Nitric Oxide: Pathophysiological Mechanisms

1995 • 876 citations

Nitric oxide synthase and neuronal vulnerability in parkinson's disease

1996 • 588 citations

Nitric Oxide in the Nervous System

1995 • 503 citations

Inducible nitric oxide synthase gene expression in the brain during systemic inflammation

1996 • 287 citations

Nitric oxide regulates luteinizing hormone-releasing hormone secretion.

1993 • 225 citations

Interleukin (IL) 1β, IL-1 receptor antagonist, IL-10, and IL-13 gene expression in the central nervous system and anterior pituitary during systemic inflammation: Pathophysiological implications

1997 • 222 citations

Induction of Nitric Oxide Synthase mRNA Expression

1995 • 215 citations

[3H]CGP 39653: a new N-methyl-D-aspartate antagonist radioligand with low nanomolar affinity in rat brain

1991 • 212 citations

1,25-Dihydroxyvitamin D3 inhibits the expression of inducible nitric oxide synthase in rat central nervous system during experimental allergic encephalomyelitis

1997 • 200 citations

Reproductive aging in the male brown-Norway rat: a model for the human.

1993 • 197 citations

Histochemical Localization of Nitric Oxide Neurons in the Hypothalamus: Association with Gonadotropin-Releasing Hormone Neurons and Co-Localization with N-Methyl-D-Aspartate Receptors

1995 • 192 citations

Nitric Oxide Synthase in Reactive Astrocytes Adjacent to β-Amyloid Plaques

1997 • 183 citations

Reduction of penile nitric oxide synthase in diabetic BB/WORdp (type I) and BBZ/WORdp (type II) rats with erectile dysfunction.

1995 • 182 citations

Influence of Age on Pulsatile Luteinizing Hormone Release and Responsiveness of the Gonadotrophs to Sex Hormone Feedback in Men

1987 • 161 citations

Characterization of NMDA Receptor Subunit‐Specific Antibodies: Distribution of NR2A and NR2B Receptor Subunits in Rat Brain and Ontogenic Profile in the Cerebellum

1995 • 159 citations

Characterization of quisqualate recognition sites in rat brain tissue usingDl-[3H]?-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) and a filtration assay

1987 • 158 citations

Extensive peroxynitrite activity during progressive stages of central nervous system inflammation

1997 • 157 citations

Expression of inducible nitric oxide synthase by neurones following exposure to endotoxin and cytokine

1994 • 157 citations

Gaseous Transmitters and Neuroendocrine Regulation

1997 • 145 citations

Exitatory Amino Acids in Health and Disease

1995 • 139 citations

Episodic Luteinizing Hormone (LH) Secretion and the Response of LH and Follicle-Stimulating Hormone to LH-Releasing Hormone in Aged Men: Evidence for Coexistent Primary Testicular Insufficiency and an Impairment in Gonadotropin Secretion*

1982 • 135 citations

Synergistic Induction of Nitric Oxide by β-Amyloid and Cytokines in Astrocytes

1996 • 134 citations

Nitric Oxide Production and Neurotoxicity Mediated by Activated Microglia from Human versus Mouse Brain

1994 • 128 citations

Cloning of Rat and Human Inducible Penile Nitric Oxide Synthase. Application for Gene Therapy of Erectile Dysfunction1

1997 • 125 citations

What Does Cell Death Have To Do with Aging?

1997 • 122 citations

Age Decreases Nitric Oxide Synthase-Containing Nerve Fibers in the Rat Penis

1997 • 121 citations

The nitric oxide hypothesis of brain aging

1997 • 113 citations

Decline in immediate early gene expression in gonadotropin-releasing hormone neurons during proestrus in regularly cycling, middle-aged rats.

1994 • 109 citations

The Brown Norway Rat as a Model of Male Reproductive Aging: Evidence for Both Primary and Secondary Testicular Failure

1994 • 101 citations

Evidence that Brain Nitric Oxide Synthase is the Major Nitric Oxide Synthase Isoform in the Hypothalamus of the Adult Female Rat and that Nitric Oxide Potently Regulates Hypothalamic cGMP Levels

1996 • 100 citations

Excitatory amino acid receptors and neurodegeneration.

1995 • 97 citations

Cloning of a Novel Neuronal Nitric Oxide Synthase Expressed in Penis and Lower Urinary Tract

1996 • 96 citations

Nitric oxide synthesized by gonadotropin-releasing hormone neurons is a mediator of N-methyl-D-aspartate (NMDA)-induced GnRH secretion.

1994 • 88 citations

Role of the Cytokines in the Hypothalamic-Pituitary-Adrenal and Gonadal Axes

1995 • 85 citations

In Vivo Expression of Inducible Nitric Oxide Synthase in Cerebellar Neurons

1996 • 85 citations

Evidence for a Physiological Role for Nitric Oxide in the Regulation of the LH Surge: Effect of Central Administration of Antisense Oligonucleotides to Nitric Oxide Synthase

1996 • 79 citations

NMDA and nitric oxide act through the cGMP signal transduction pathway to repress hypothalamic gonadotropin-releasing hormone gene expression.

1996 • 78 citations

Growth hormone-releasing hormone and growth hormone-releasing peptide as therapeutic agents to enhance growth hormone secretion in disease and aging.

1997 • 78 citations

Aging Results in Attenuated Gonadotropin Releasing Hormone-Luteinizing Hormone Axis Responsiveness to Glutamate Receptor Agonist N-Methyl-D-Aspartate*

1998 • 77 citations

Evidence in support of nitric oxide (NO) involvement in the cyclic release of prolactin and LH surges

1994 • 76 citations

Nitric oxide synthase content of hypothalamic explants: increase by norepinephrine and inactivated by NO and cGMP.

1996 • 75 citations

Fasting-induced increases in food intake and neuropeptide Y gene expression are attenuated in aging male brown Norway rats.

1996 • 73 citations

Oxytocin stimulates the release of luteinizing hormone-releasing hormone from medial basal hypothalamic explants by releasing nitric oxide

1997 • 71 citations

Rodent models of memory dysfunction in Alzheimer's disease and normal aging: Moving beyond the cholinergic hypothesis

1994 • 70 citations

Reduction in the number of NADPH-diaphorase-positive cells in the cerebral cortex and striatum in aged rats

1996 • 69 citations

Age-related decrease of the NMDA receptor-mediated noradrenaline release in rat hippocampus and partial restoration by D-cycloserine

1993 • 68 citations

Adipose Tissue-Derived Tumor Necrosis Factor- Activity Is Elevated in Older Rats

1997 • 65 citations

Adrenal Control of Erectile Function and Nitric Oxide Synthase in the Rat Penis*

1997 • 64 citations

Decreased gonadotropin-releasing hormone neurosecretory response to glutamate agonists in middle-aged female rats on proestrus afternoon: a possible role in reproductive aging?

1996 • 61 citations

Glutamate: A major neuroendocrine excitatory signal mediating steroid effects on gonadotropin secretion

1995 • 59 citations

Effects of aging on NMDA and MK801 binding sites in mice

1993 • 59 citations

Age-dependent loss of NMDA receptors in hippocampus, striatum, and frontal cortex of the rat: Prevention by acetyl-l-carnitine

1994 • 52 citations

The number and distribution of detectable luteinizing hormone (LH)-releasing hormone cell bodies changes in association with the preovulatory LH surge in the brains of young but not middle-aged female rats.

1994 • 51 citations

Age-Related Decreases in Serum Gonadotropin Levels and Gonadotropin-Releasing Hormone Gene Expression in the Medial Preoptic Area of the Male Rat Are Dependent upon Testicular Feedback*

1991 • 48 citations

Age-Dependent Changes of NO Synthase Activity in the Rat Brain

1995 • 47 citations

Expression of Inducible Nitric Oxide Synthase in Smooth Muscle Cells From Rat Penile Corpora Cavernosa

1995 • 47 citations

Endogenous glutamate involvement in pulsatile secretion of gonadotropin-releasing hormone: evidence from effect of glutamine and developmental changes.

1995 • 47 citations

Involvement of nitric oxide in the regulation of gonadotropin-releasing hormone release from the GT1-1 neuronal cell line.

1994 • 46 citations

Increased release of tumor necrosis factor-alpha into the cerebrospinal fluid and peripheral circulation of aged rats.

1993 • 42 citations

Ultrastructural changes in gonadotropin-releasing hormone neurons as a function of age and ovariectomy in rats

1994 • 39 citations

Loss of LH-RH neurons in the rostral forebrain of old female C57BL/6J mice

1990 • 38 citations

Morphology of Luteinizing Hormone-Releasing Hormone Neurons as a Function of Age and Hormonal Condition in the Male Rat

1989 • 37 citations

N-methyl-D-aspartate receptor density and membrane fluidity as possible determinants of the decline of passive avoidance performance in aging

1995 • 37 citations

Age-related increase in nitric oxide synthase activity in senescence accelerated mouse brain and the effect of long-term administration of superoxide radical scavenger

1996 • 34 citations

Increased expression of nitric oxide synthase in the gracile nucleus of aged rats.

1997 • 34 citations

Evidence that luteinizing hormone suppression in response to inhibitory neuropeptides, beta-endorphin, interleukin-1 beta, and neuropeptide-K, may involve excitatory amino acids.

1993 • 33 citations

Control of pulsatile secretion of gonadotrophin releasing hormone from hypothalamic explants

1993 • 33 citations

Effect of NMDA and Non-NMDA Receptor Antagonists on Pulsatile Luteinizing Hormone Secretion in the Adult Male Rat

1995 • 32 citations

The number of luteinizing hormone-releasing hormone immunoreactive neurons is significantly decreased in the forebrain of old-aged female rats

1995 • 31 citations

The function of the NMDA-receptor during normal brain aging

1994 • 28 citations

Inhibition of nitric oxide synthase by antisense techniques: investigations of the roles of NO produced by murine macrophages

1997 • 25 citations

Differential Sex Steroid Negative Feedback Regulation of Pulsatile Follicle-Stimulating Hormone Secretion in Healthy Older Men: Deconvolution Analysis and Steady- State Sex-Steroid Hormone Infusions in Frequently Sampled Healthy Older Individuals¹

1997 • 25 citations

Comparison of ultrastructural characteristics of gonadotropin-releasing hormone neurons in prepubertal and adult male rats

1995 • 24 citations

Aging and the hypothalamus: Research perspectives

1996 • 23 citations

Macrophage Inflammatory Protein-1? and Inducible Nitric Oxide Synthase Immunoreactivity in Rat Brain during Prostaglandin E₂- or Lipopolysaccharide-Induced Fever

1997 • 21 citations

Dehydroepiandrosterone administration reverses the inhibitory influence of aging on gonadotrophin-releasing hormone gene expression in the male and female rat brain

1997 • 18 citations

Nerve Growth Factor, Central Nervous System Apoptosis, and Adrenocortical Activity in Aged Fischer-344/Brown Norway F1 Hybrid Rats

1997 • 12 citations

Glycine Enhances Binding to the NMDA Receptor Complex in Aged Mice, But Does Not Correct the Aging Change

1996 • 11 citations

The effects of chronic administration of nimodipine on age‐related changes in nitric changes in nitric oxide and its synthase in senescence‐accelerated mouse brain

1997 • 9 citations