The presence of FGF2 signaling determines whether β-catenin exerts effects on proliferation or neuronal differentiation of neural stem cells

GSK-3: tricks of the trade for a multi-tasking kinase

2003 • 2,027 citations

Wnt/β-Catenin/Tcf Signaling Induces the Transcription of Axin2, a Negative Regulator of the Signaling Pathway

2002 • 1,601 citations

Regulation of Cerebral Cortical Size by Control of Cell Cycle Exit in Neural Precursors

2002 • 1,383 citations

Fibroblast Growth Factor-2 Activates a Latent Neurogenic Program in Neural Stem Cells from Diverse Regions of the Adult CNS

1999 • 916 citations

Distinct Neural Stem Cells Proliferate in Response to EGF and FGF in the Developing Mouse Telencephalon

1999 • 807 citations

Development of neuronal precursor cells and functional postmitotic neurons from embryonic stem cells in vitro

1996 • 775 citations

β-catenin: a key mediator of Wnt signaling

1998 • 746 citations

The Structure of the β-Catenin/E-Cadherin Complex and the Molecular Basis of Diverse Ligand Recognition by β-Catenin

2001 • 737 citations

FGF Signaling Regulates Mesoderm Cell Fate Specification and Morphogenetic Movement at the Primitive Streak

2001 • 675 citations

A mitogen gradient of dorsal midline Wnts organizes growth in the CNS

2002 • 672 citations

Control of neural crest cell fate by the Wnt signalling pathway

1998 • 501 citations

Distinct roles for bFGF and NT-3 in the regulation of cortical neurogenesis

1995 • 476 citations

β-Catenin signals regulate cell growth and the balance between progenitor cell expansion and differentiation in the nervous system

2003 • 463 citations

FGF2 Concentration Regulates the Generation of Neurons and Glia from Multipotent Cortical Stem Cells

1997 • 455 citations

Basic Fibroblast Growth Factor (Fgf2) Is Necessary for Cell Proliferation and Neurogenesis in the Developing Cerebral Cortex

2000 • 419 citations

Changes in cerebral cortex size are governed by fibroblast growth factor during embryogenesis

1999 • 397 citations

Wingless inactivates glycogen synthase kinase-3 via an intracellular signalling pathway which involves a protein kinase C.

1996 • 396 citations

Glycogen Synthase Kinase-3: Properties, Functions, and Regulation

2001 • 390 citations

WNT Signals Control FGF-Dependent Limb Initiation and AER Induction in the Chick Embryo

2001 • 360 citations

Wnt-induced dephosphorylation of Axin releases beta -catenin from the Axin complex

1999 • 345 citations

Wnt signaling in Xenopus embryos inhibits Bmp4 expression and activates neural development

1999 • 338 citations

Lineage-specific requirements of β-catenin in neural crest development

2002 • 312 citations

Wnt signaling plays an essential role in neuronal specification of the dorsal spinal cord

2002 • 276 citations

FGF4, a direct target of LEF1 and Wnt signaling, can rescue the arrest of tooth organogenesis in Lef1^−/− mice

2002 • 266 citations

Regulation of β-Catenin Structure and Activity by Tyrosine Phosphorylation

2001 • 258 citations

Increased Neuronal Production, Enlarged Forebrains and Cytoarchitectural Distortions in beta-Catenin Overexpressing Transgenic Mice

2003 • 250 citations

Regulated binding of PTP1B-like phosphatase to N-cadherin: control of cadherin-mediated adhesion by dephosphorylation of beta-catenin.

1996 • 221 citations

Microphthalmia-associated transcription factor interacts with LEF-1, a mediator of Wnt signaling

2002 • 221 citations

Specification of dorsal telencephalic character by sequential Wnt and FGF signaling

2003 • 192 citations

bFGF, neurotrophins, and the control of cortical neurogenesis

1995 • 161 citations

Prospective Cell Sorting of Embryonic Rat Neural Stem Cells and Neuronal and Glial Progenitors Reveals Selective Effects of Basic Fibroblast Growth Factor and Epidermal Growth Factor on Self-Renewal and Differentiation

2003 • 152 citations

Early embryonic expression ofFGF4/6/9gene and its role in the induction of mesenchyme and notochord inCiona savignyiembryos

2002 • 151 citations

β-Catenin Is Essential and Sufficient for Skeletal Myogenesis in P19 Cells

2002 • 138 citations

A disrupted balance between Bmp/Wnt and Fgf signaling underlies the ventralization of the Gli3 mutant telencephalon

2003 • 134 citations

Wnt Regulation of Progenitor Maturation in the Cortex Depends on Shh or Fibroblast Growth Factor 2

2003 • 132 citations

Direct regulation of the Xenopus engrailed-2 promoter by the Wnt signaling pathway, and a molecular screen for Wnt-responsive genes, confirm a role for Wnt signaling during neural patterning in Xenopus

1999 • 129 citations

Fibroblast Growth Factor-2 Induces Lef/Tcf-dependent Transcription in Human Endothelial Cells

2002 • 127 citations

Neural Induction in the Absence of Mesoderm: β-Catenin-Dependent Expression of Secreted BMP Antagonists at the Blastula Stage in Xenopus

2001 • 126 citations

Fibroblast Growth Factor 1 Regulates Signaling via the Glycogen Synthase Kinase-3β Pathway

2002 • 120 citations

The Wnt/β-Catenin Pathway Posteriorizes Neural Tissue in Xenopus by an Indirect Mechanism Requiring FGF Signalling

2001 • 116 citations

Up-regulation of the ectodermal-neural cortex 1 (ENC1) gene, a downstream target of the beta-catenin/T-cell factor complex, in colorectal carcinomas.

2001 • 111 citations

Sonic Hedgehog and BMP2 Exert Opposing Actions on Proliferation and Differentiation of Embryonic Neural Progenitor Cells

1999 • 105 citations

The Wnt-activated Xiro1 gene encodes a repressor that is essential for neural development and downregulates Bmp4

2001 • 102 citations

6 Fibroblast Growth Factor Signaling Regulates Growth and Morphogenesis at Multiple Steps during Brain Development

1999 • 98 citations

Differential expression of the HMG box transcription factors XTcf-3 and XLef-1 during early Xenopus development

1998 • 78 citations

Wnt-1 promotes neuronal differentiation and inhibits gliogenesis in P19 cells

2002 • 78 citations

Involvement of NLK and Sox11 in neural induction in Xenopus development

2002 • 61 citations

In VitroCell Density-Dependent Clonal Growth of EGF-Responsive Murine Neural Progenitor Cells under Serum-Free Conditions

1997 • 59 citations

The Role of GSK3β in Regulating Neuronal Differentiation inXenopus laevis

1998 • 51 citations

Ectopic Expression of Axin Blocks Neuronal Differentiation of Embryonic Carcinoma P19 Cells

2003 • 45 citations

Regulated Expression of Wnt Family Members during Neuroectodermal Differentiation of P19 Embryonal Carcinoma Cells: Overexpression of Wnt-1 Perturbs Normal Differentiation-Specific Properties

1994 • 41 citations

FGF-1 and FGF-2 regulate the expression of E-cadherin and catenins in pancreatic adenocarcinoma

2001 • 39 citations

Properties of Ectopic Neurons Induced byXenopusNeurogenin1 Misexpression

1998 • 33 citations

Expression of Ngn1, Ngn2, Cash1, Gsh2 and Sfrp1 in the developing chick telencephalon

2002 • 27 citations

Identification and biochemical characterization of secreted Wnt-1 protein from P19 embryonal carcinoma cells induced to differentiate along the neuroectodermal lineage.

1994 • 17 citations

A fragment of theneurogenin1 gene confers regulated expression of a reporter gene in vitro and in vivo

2000 • 16 citations