Phosphorylation and degradation of HMG CoA reductase

Amino Acid Sequences Common to Rapidly Degraded Proteins: The PEST Hypothesis

1986 • 2,566 citations

Multivalent feedback regulation of HMG CoA reductase, a control mechanism coordinating isoprenoid synthesis and cell growth.

1980 • 1,195 citations

Regulation of transmembrane signaling by receptor phosphorylation

1987 • 678 citations

Protein Phosphatases: Properties and Role in Cellular Regulation

1983 • 645 citations

Proteolytic activation of calcium-activated, phospholipid-dependent protein kinase by calcium-dependent neutral protease.

1983 • 601 citations

A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis

1987 • 569 citations

Membrane-bound domain of HMG CoA reductase is required for sterol-enhanced degradation of the enzyme

1985 • 384 citations

Modulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity with cAMP and with protein fractions of rat liver cytosol

1973 • 309 citations

Domain structure of 3-hydroxy-3-methylglutaryl coenzyme A reductase, a glycoprotein of the endoplasmic reticulum.

1985 • 301 citations

Comparative specificity and kinetic studies on porcine calpain I and calpain II with naturally occurring peptides and synthetic fluorogenic substrates.

1984 • 291 citations

Nucleotide sequence of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase, a glycoprotein of endoplasmic reticulum

1984 • 263 citations

Interconversion of active and inactive forms of rat liver hydroxymethylglutaryl-CoA reductase.

1977 • 231 citations

Regulation of synthesis and degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase by low density lipoprotein and 25-hydroxycholesterol in UT-1 cells.

1982 • 203 citations

Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase and its mRNA in rat liver as studied with a monoclonal antibody and a cDNA probe.

1983 • 200 citations

Diurnal variation and cholesterol regulation of hepatic HMG-CoA reductase activity

1969 • 183 citations

An analysis of the kinetics of rat liver tryptophan pyrrolase induction: The significance of both enzyme synthesis and degradation

1964 • 181 citations

Mevalonolactone inhibits the rate of synthesis and enhances the rate of degradation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in rat hepatocytes.

1983 • 156 citations

Modulation of hydroxymethylglutaryl-CoA reductase activity, reductase kinase activity, and cholesterol synthesis in rat hepatocytes in response to insulin and glucagon.

1979 • 143 citations

Regulation of enzyme levels by proteolysis: The role of pest regions

1988 • 139 citations

The membrane domain of 3-hydroxy-3-methylglutaryl-coenzyme A reductase confers endoplasmic reticulum localization and sterol-regulated degradation onto beta-galactosidase.

1988 • 128 citations

Properties of purified rat hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase and regulation of enzyme activity.

1980 • 118 citations

Increase in membrane cholesterol: A possible trigger for degradation of HMG CoA reductase and crystalloid endoplasmic reticulum in UT-1 cells

1984 • 118 citations

The hormonal control of glycogen metabolism: dephosphorylation of protein phosphatase inhibitor‐1 in vivo in response to insulin

1980 • 95 citations

Heterologous Expression of Excitability Proteins: Route to More Specific Drugs?

1988 • 95 citations

Diurnal rhythm of rat liver mRNAs encoding 3-hydroxy-3-methylglutaryl coenzyme A reductase. Correlation of functional and total mRNA levels with enzyme activity and protein.

1984 • 94 citations

Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in avian myeloblasts. Mode of action of 25-hydroxycholesterol.

1983 • 93 citations

Regulation of Liver 3-Hydroxy-3-methylglutaryl-CoA Reductase

1981 • 89 citations

Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase by reversible phosphorylation-dephosphorylation.

1985 • 80 citations

Regulation of liver hydroxymethylglutaryl-CoA reductase by a bicyclic phosphorylation system.

1981 • 79 citations

Phosphorylation of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase and modulation of its enzymic activity by calcium-activated and phospholipid-dependent protein kinase.

1985 • 78 citations

Modulation of the enzymic activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase by multiple kinase systems involving reversible phosphorylation: A review

1987 • 72 citations

Phosphorylation of Native 97-kDa 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase from Rat Liver

1989 • 70 citations

Evidence indicating that inactivation of 3-hydroxy-3-methylglutaryl coenzyme A reductase by low density lipoprotein or by 25-hydroxycholesterol requires mediator protein(s) with rapid turnover rate.

1981 • 67 citations

Regulation of Hmg-coa Reductase

1985 • 67 citations

Diurnal changes in the fraction of 3-hydroxy-3-methylglutaryl-CoA reductase in the active form in rat liver microsomal fractions

1984 • 61 citations

Effect of plasma lipoproteins and lecithin-cholesterol dispersions on the activity of 3-hydroxy-3-methylglutaryl-coenzyme a reductase of isolated rat hepatocytes

1975 • 59 citations

Proteinase involvement in the solubilization of 3-hydroxy-3-methylglutaryl coenzyme a reductase

1981 • 57 citations

Studies on the mechanisms of the rapid modulation of 3-hydroxy-3-methylglutaryl coenzyme a reductase in intact liver by mevalonolactone and 25-hydroxycholesterol

1980 • 54 citations

Overproduction of a M _r 92,000 protomer of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in compactin-resistant C100 cells

1983 • 52 citations

Purification of 3-hydroxy-3-methylglutaryl coenzyme A reductase from rat liver

1979 • 49 citations

Phosphorylation of microsomal HMG CoA reductase increases susceptibility to proteolytic degradation

1984 • 46 citations

Phosphorylation and modulation of the enzymic activity of native and protease-cleaved purified hepatic 3-hydroxy-3-methylglutaryl-coenzyme A reductase by a calcium/calmodulin-dependent protein kinase.

1987 • 43 citations

Inhibition of lysosomal protein degradation inhibits the basal degradation of 3-hydroxy-3-methylglutaryl coenzyme A reductase.

1987 • 40 citations

ATP-dependent degradation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in permeabilized cells.

1987 • 37 citations

Short-term regulation of hydroxymethylglutaryl coenzyme a reductase by reversible phosphorylation: Modulation of reductase phosphatase in rat hepatocytes

1982 • 36 citations

The Nucleotide Sequence of Syrian Hamster HMG-CoA Reductase cDNA

1985 • 35 citations

Regulation of 3-hydroxy-3-methylglutaryl coenzyme a reductase activity in human fibroblasts by reversible phosphorylation: Modulation of enzymatic activity by low density lipoprotein, sterols, and mevalonolactone

1986 • 31 citations

Modification of 3-hydroxy-3-methylglutaryl coenzyme A reductase immunoinhibition curves by substrates and inhibitors. Evidence for conformational changes leading to alterations in antigenicity.

1982 • 28 citations

Acute effects of starvation and treatment of rats with anti-insulin serum, glucagon and catecholamines on the state of phosphorylation of hepatic 3-hydroxy-3-methylglutaryl-CoA reductase in vivo

1987 • 24 citations

Evidence for multiple phosphorylation sites in rat liver 3-hydroxy-3-methylglutaryl Coenzyme A reductase

1983 • 20 citations

Affinity labeling of the catalytic and AMP allosteric sites of 3-hydroxy-3-methylglutaryl-coenzyme A reductase kinase by 5'-p-fluorosulfonylbenzoyladenosine.

1987 • 18 citations

Phosphorylation of HMG‐CoA reductase induced by mevalonate accelerates its rate of degradation in isolated rat hepatocytes

1986 • 17 citations

Reversible Phosphorylation of Hepatic HMG-CoA Reductase in Endocrine and Feedback Control of Cholesterol Biosynthesis

1985 • 10 citations

Structure and Expression of 3‐Hydroxy‐3‐methylglutaryl Coenzyme A Reductase^a

1986 • 7 citations

Phosphorylation state of HMG CoA reductase affects its catalytic activity and degradation

1986 • 4 citations