ATP-dependent degradation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in permeabilized cells.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Regulation of HMG-CoA Reductase

1976 • 743 citations

Membrane-bound domain of HMG CoA reductase is required for sterol-enhanced degradation of the enzyme

1985 • 384 citations

Modulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity with cAMP and with protein fractions of rat liver cytosol

1973 • 309 citations

Active and inactive forms of 3-hydroxy-3-methylglutaryl coenzyme A reductase in the liver of the rat. Comparison with the rate of cholesterol synthesis in different physiological states.

1979 • 309 citations

Domain structure of 3-hydroxy-3-methylglutaryl coenzyme A reductase, a glycoprotein of the endoplasmic reticulum.

1985 • 301 citations

Ubiquitin: Roles in protein modification and breakdown

1983 • 297 citations

Ubiquitin-lysozyme conjugates. Identification and characterization of an ATP-dependent protease from rabbit reticulocyte lysates.

1986 • 278 citations

The cytoskeleton of digitonin-treated rat hepatocytes.

1980 • 238 citations

Regulation of synthesis and degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase by low density lipoprotein and 25-hydroxycholesterol in UT-1 cells.

1982 • 203 citations

Early events in the stimulation of mammary tumor virus RNA synthesis by glucocorticoids. Novel assays of transcription rates.

1984 • 202 citations

Activity of peroxisomal enzymes and intracellular distribution of catalase in Zellweger syndrome

1984 • 200 citations

Human 3-hydroxy-3-methylglutaryl coenzyme A reductase. Conserved domains responsible for catalytic activity and sterol-regulated degradation.

1985 • 199 citations

Determination of mitochondrial/cytosolic metabolite gradients in isolated rat liver cells by cell disruption

1977 • 164 citations

Mevalonolactone inhibits the rate of synthesis and enhances the rate of degradation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in rat hepatocytes.

1983 • 156 citations

Molecular cloning of 3-hydroxy-3-methylglutaryl coenzyme a reductase and evidence for regulation of its mRNA.

1982 • 147 citations

A mild procedure for the rapid release of cytoplasmic enzymes from cultured animal cells

1979 • 144 citations

3-Hydroxy-3-methylglutaryl-CoA reductase: a transmembrane glycoprotein of the endoplasmic reticulum with N-linked "high-mannose" oligosaccharides.

1983 • 136 citations

Increase in membrane cholesterol: A possible trigger for degradation of HMG CoA reductase and crystalloid endoplasmic reticulum in UT-1 cells

1984 • 118 citations

Interaction of Digitonin and Its Analogs with Membrane Cholesterol1

1984 • 115 citations

The ATP dependence of the degradation of short- and long-lived proteins in growing fibroblasts.

1985 • 113 citations

Quantitation of intracellular membrane-bound enzymes and receptors in digitonin-permeabilized cells

1983 • 101 citations

Inactivation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in vitro. An adenine nucleotide-dependent reaction catalyzed by a factor in human fibroblasts.

1975 • 98 citations

Regulation of rat liver 3-hydroxy-3-methylglutaryl coenzyme A reductase. Evidence for thiol-dependent allosteric modulation of enzyme activity.

1984 • 96 citations

Characterization and regulation of reductase kinase, a protein kinase that modulates the enzymic activity of 3-hydroxy-3-methylglutaryl-coenzyme A reductase

1979 • 76 citations

Thyrotropin-releasing hormone mobilizes Ca2+ from endoplasmic reticulum and mitochondria of GH3 pituitary cells: characterization of cellular Ca2+ pools by a method based on digitonin permeabilization.

1982 • 71 citations

A soluble ATP-dependent system for protein degradation from murine erythroleukemia cells. Evidence for a protease which requires ATP hydrolysis but not ubiquitin.

1985 • 70 citations

Regulation of cholesterol biosynthesis in enucleated cells.

1981 • 67 citations

Inhibition of degradation of 3-hydroxy-3-methylglutaryl coenzyme A reductase by mevinolin.

1983 • 65 citations

Large Scale Isolation and Characterization of Calf Thymocyte Plasma Membranes

1974 • 61 citations

Inactive 3-hydroxy-3-methylglutaryl-coenzyme a reductase in broken cell preparations of various mammalian tissues and cell cultures

1979 • 61 citations

Characteristics of rat liver microsomal 3-hydroxy-3-methylglutaryl-coenzyme A reductase

1986 • 61 citations

Permeabilization of animal cells for kinetic studies of intracellular enzymes: in situ behavior of the glycolytic enzymes of erythrocytes.

1980 • 54 citations

Chloroquine inhibits cyclization of squalene oxide to lanosterol in mammalian cells.

1984 • 47 citations

Phosphorylation of microsomal HMG CoA reductase increases susceptibility to proteolytic degradation

1984 • 46 citations

Inhibition of lysosomal protein degradation inhibits the basal degradation of 3-hydroxy-3-methylglutaryl coenzyme A reductase.

1987 • 40 citations

Methods in Membrane Biology

1976 • 38 citations

HMG-CoA reductase kinase: measurement of activity by methods that preclude interference by inhibitors of HMG-CoA reductase activity or by mevalonate kinase.

1982 • 24 citations

Novel approach to the study of the regulation of hormone‐sensitive lipase in rat adipocytes

1983 • 24 citations

A particle-associated ATP-dependent proteolytic activity in erythroleukemia cells.

1985 • 24 citations

ATP depletion in human platelets caused by permeabilization with saponin does not prevent serotonin secretion induced by collagen

1985 • 21 citations

Phosphorylation of HMG‐CoA reductase induced by mevalonate accelerates its rate of degradation in isolated rat hepatocytes

1986 • 17 citations