Inhibition of lysosomal protein degradation inhibits the basal degradation of 3-hydroxy-3-methylglutaryl coenzyme A reductase.

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Enzymatic Determination of Total Serum Cholesterol

1974 • 9,182 citations

Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents.

1978 • 2,146 citations

Fluorographic detection of radioactivity in polyacrylamide gols with the water-soluble fluor, sodium salicylate

1979 • 1,976 citations

Proteinases in mammalian cells and tissues

1978 • 981 citations

Control of Enzyme Levels in Animal Tissues

1970 • 680 citations

Mechanisms of Intracellular Protein Breakdown

1982 • 647 citations

Ubiquitin dependence of selective protein degradation demonstrated in the mammalian cell cycle mutant ts85

1984 • 533 citations

Thermolability of ubiquitin-activating enzyme from the mammalian cell cycle mutant ts85

1984 • 522 citations

Inhibition of the Lysosomal Pathway of Protein Degradation in Isolated Rat Hepatocytes by Ammonia, Methylamine, Chloroquine and Leupeptin

1979 • 466 citations

Inhibition of proteolytic degradation of low density lipoprotein in human fibroblasts by chloroquine, concanavalin A, and Triton WR 1339.

1975 • 306 citations

Domain structure of 3-hydroxy-3-methylglutaryl coenzyme A reductase, a glycoprotein of the endoplasmic reticulum.

1985 • 301 citations

Ubiquitin: Roles in protein modification and breakdown

1983 • 297 citations

Nucleotide sequence of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase, a glycoprotein of endoplasmic reticulum

1984 • 263 citations

Effects of exogenous amines on mammalian cells, with particular reference to membrane flow

1984 • 252 citations

A MORPHOMETRIC STUDY OF THE REMOVAL OF PHENOBARBITAL-INDUCED MEMBRANES FROM HEPATOCYTES AFTER CESSATION OF TREATMENT

1973 • 250 citations

Appearance of crystalloid endoplasmic reticulum in compactin-resistant Chinese hamster cells with a 500-fold increase in 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

1982 • 248 citations

Regulation of synthesis and degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase by low density lipoprotein and 25-hydroxycholesterol in UT-1 cells.

1982 • 203 citations

ENZYME-MEMBRANE RELATIONSHIP IN PHENOBARBITAL INDUCTION OF SYNTHESIS OF DRUG-METABOLIZING ENZYME SYSTEM AND PROLIFERATION OF ENDOPLASMIC MEMBRANES

1966 • 176 citations

Accumulation of autophagosomes after inhibition of hepatocytic protein degradation by vinblastine, leupeptin or a lysosomotropic amine

1982 • 162 citations

The effect of protease inhibitors and decreased temperature on the degradation of different classes of proteins in cultured hepatocytes

1979 • 157 citations

Mevalonolactone inhibits the rate of synthesis and enhances the rate of degradation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in rat hepatocytes.

1983 • 156 citations

Regulation of Hepatic 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase

1972 • 154 citations

Molecular cloning of 3-hydroxy-3-methylglutaryl coenzyme a reductase and evidence for regulation of its mRNA.

1982 • 147 citations

3-Hydroxy-3-methylglutaryl-CoA reductase: a transmembrane glycoprotein of the endoplasmic reticulum with N-linked "high-mannose" oligosaccharides.

1983 • 136 citations

Inhibition of proteolytic activity of calcium activated neutral protease by leupeptin and antipain

1978 • 130 citations

Establishment of Cell Lines <i>in vitro</i> from a Mammary Ascites Tumor of Mouse and Biological Properties of the Established Lines in a Serum Containing Medium

1966 • 124 citations

Increase in membrane cholesterol: A possible trigger for degradation of HMG CoA reductase and crystalloid endoplasmic reticulum in UT-1 cells

1984 • 118 citations

Properties of purified rat hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase and regulation of enzyme activity.

1980 • 118 citations

Alterations in the rates of synthesis and degradation of rat liver 3-hydroxy-3-methylglutaryl coenzyme A reductase produced by cholestyramine and mevinolin.

1983 • 117 citations

Degradation of short and long lived proteins in isolated rat liver lysosomes. Effects of pH, temperature, and proteolytic inhibitors.

1985 • 105 citations

Effects of amino acids, ammonia and leupeptin on protein synthesis and degradation in isolated rat hepatocytes

1978 • 101 citations

Turnover of membrane proteins: Kinetics of induction and degradation of seven forms of rat liver microsomal cytochrome P-450, NADPH-cytochrome P-450 reductase, and epoxide hydrolase

1984 • 100 citations

Isolation and analysis of lipoproteins secreted by rat liver hepatocytes

1984 • 97 citations

3-Hydroxy-3-methylglutaryl-coenzyme A reductase

1982 • 96 citations

Ultrastructural analysis of crystalloid endoplasmic reticulum in ut-1 cells and its disappearance in response to cholesterol

1983 • 95 citations

Radioimmune precipitation of 3-hydroxy-3-methylglutaryl coenzyme A reductase from Chinese hamster fibroblasts. Effect of 25-hydroxycholesterol.

1981 • 93 citations

Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in avian myeloblasts. Mode of action of 25-hydroxycholesterol.

1983 • 93 citations

Uptake—Microautophagy—and degradation of exogenous proteins by isolated rat liver lysosomes

1985 • 85 citations

A temperature-sensitive mutant of cultured mouse cells defective in chromosome condensation

1980 • 77 citations

Regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase mRNA levels in rat liver.

1983 • 73 citations

Macrophage protein turnover. Evidence for lysosomal participation in basal proteolysis

1979 • 73 citations

Evidence indicating that inactivation of 3-hydroxy-3-methylglutaryl coenzyme A reductase by low density lipoprotein or by 25-hydroxycholesterol requires mediator protein(s) with rapid turnover rate.

1981 • 67 citations

Regulation of cholesterol biosynthesis in enucleated cells.

1981 • 67 citations

Proteinase involvement in the solubilization of 3-hydroxy-3-methylglutaryl coenzyme a reductase

1981 • 57 citations

Chloroquine inhibits cyclization of squalene oxide to lanosterol in mammalian cells.

1984 • 47 citations

Phosphorylation of microsomal HMG CoA reductase increases susceptibility to proteolytic degradation

1984 • 46 citations

Elimination of excess smooth endoplasmic reticulum after phenobarbital administration.

1980 • 44 citations

Effects of weak bases on the degradation of endogenous and exogenous proteins by rat yolk sacs

1980 • 40 citations

Inhibition of hepatic cholesterol biosynthesis by chloroquine

1981 • 38 citations

Ultrastructural studies on autolysosomes in rat hepatocytes after leupeptin treatment

1983 • 37 citations

The role of increased proteolysis in the atrophy and arrest of proliferation in serum‐deprived fibroblasts

1984 • 36 citations

Protein turnover and proliferation. Turnover kinetics associated with the elevation of 3T3-cell acid-proteinase activity and cessation of net protein gain

1982 • 33 citations

Inhibition of protein synthesis blocks the response to 25-hydroxycholesterol by inhibiting degradation of hydroxymethylglutaryl-CoAreductase

1982 • 31 citations

Disappearance of a basic chromosomal protein from cells of a mouse temperature-sensitive mutant defective in histone phosphorylation

1980 • 31 citations

The regulation of proteolysis in normal fibroblasts as they approach confluence. Evidence for the participation of the lysosomal system

1982 • 28 citations

Inhibition of pyruvate carboxylase degradation and total protein breakdown by lysosomotropic agents in 3T3-L1 cells

1983 • 27 citations

Mechanisms of protein turnover in cultured fibroblasts

1980 • 24 citations

Cytochrome P-450 linked mixed function oxidase turnover of microsomal components and effects of inducers on the turnover phospholipids, proteins and specific enzymes

1980 • 21 citations

High density lipoproteins and lecithin dispersions increase the activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase by increasing the rate of synthesis and decreasing the rate of degradation of the enzyme.

1984 • 18 citations

Stimulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in mouse uterine epithelial cells by oestradiol-17 β

1984 • 8 citations