Regulation of enzyme levels by proteolysis: The role of pest regions

A new method for predicting signal sequence cleavage sites

1986 • 4,629 citations

Amino Acid Sequences Common to Rapidly Degraded Proteins: The PEST Hypothesis

1986 • 2,566 citations

In Vivo Half-Life of a Protein Is a Function of Its Amino-Terminal Residue

1986 • 1,942 citations

Intracellular Protein Degradation in Mammalian and Bacterial Cells

1974 • 1,775 citations

Cyclin: A protein specified by maternal mRNA in sea urchin eggs that is destroyed at each cleavage division

1983 • 1,506 citations

Intracellular Protein Degradation in Mammalian and Bacterial Cells: Part 2

1976 • 1,060 citations

PROTEIN KINASES IN THE BRAIN

1985 • 559 citations

Purification of two high molecular weight proteases from rabbit reticulocyte lysate.

1987 • 542 citations

Ubiquitin dependence of selective protein degradation demonstrated in the mammalian cell cycle mutant ts85

1984 • 533 citations

The common 90-kd protein component of non-transformed ‘8S’ steroid receptors is a heat-shock protein.

1985 • 527 citations

Thermolability of ubiquitin-activating enzyme from the mammalian cell cycle mutant ts85

1984 • 522 citations

Post-translational regulation of the 54K cellular tumor antigen in normal and transformed cells.

1981 • 491 citations

Intracellular Ca2+-dependent protease (CALPAIN) and its high-molecular-weight endogenous inhibitor (CALPASTATIN)

1981 • 374 citations

Evidence that Pituitary Cation‐Sensitive Neutral Endopeptidase Is a Multicatalytic Protease Complex

1983 • 356 citations

Specific interaction between the p53 cellular tumour antigen and major heat shock proteins

1986 • 354 citations

Splice Junctions: Association with Variation in Protein Structure

1983 • 261 citations

Amino-terminal processing of mutant forms of yeast iso-1-cytochrome c. The specificities of methionine aminopeptidase and acetyltransferase.

1985 • 239 citations

Immunological evidence for the association of p53 with a heat shock protein, hsc70, in p53-plus-ras-transformed cell lines.

1987 • 237 citations

Role of the alpha-amino group of protein in ubiquitin-mediated protein breakdown.

1984 • 232 citations

Red light-induced formation of ubiquitin-phytochrome conjugates: Identification of possible intermediates of phytochrome degradation

1987 • 224 citations

E1a regions of the human adenoviruses and of the highly oncogenic simian adenovirus 7 are closely related

1985 • 213 citations

Prolyl endopeptidase

1983 • 203 citations

Cloning and sequencing of the ornithine decarboxylase gene from Trypanosoma brucei. Implications for enzyme turnover and selective difluoromethylornithine inhibition.

1987 • 181 citations

THE SYNTHESIS AND FUNCTION OF PROTEASES IN SACCHAROMYCES: GENETIC APPROACHES

1984 • 179 citations

Antiglucocorticosteroid effects suggest why steroid hormone is required for receptors to bind DNA in vivo but not in vitro

1987 • 179 citations

The protein substrate binding site of the ubiquitin-protein ligase system.

1986 • 178 citations

Control of thymidine kinase mRNA during the cell cycle.

1987 • 176 citations

Use of peptide tagging to detect proteins expressed from cloned genes: deletion mapping functional domains of Drosophila hsp 70.

1984 • 175 citations

Calcium activated neutral protease: domain structure and activity regulation

1987 • 168 citations

Control of Enzyme Levels in Mammalian Tissues

1973 • 166 citations

Endogenous inhibitor for calcium-dependent cysteine protease contains four internal repeats that could be responsible for its multiple reactive sites.

1987 • 164 citations

Using Recombinant DNA Techniques to Study Protein Targeting in the Eucaryotic Cell

1985 • 158 citations

Signals guiding proteins to their correct locations in mitochondria

1987 • 145 citations

Microinjection of ubiquitin: changes in protein degradation in HeLa cells subjected to heat-shock.

1987 • 145 citations

Role of arginine-tRNA in protein degradation by the ubiquitin pathway

1987 • 142 citations

Towards a comparative anatomy of N-terminal topogenic protein sequences

1986 • 140 citations

Protein Kinases in the Brain

1985 • 134 citations

Characterization of sites of tyrosine sulfation in proteins and criteria for predicting their occurrence

1986 • 121 citations

Regulation of catabolism of microinjected ribonuclease A. Identification of residues 7-11 as the essential pentapeptide.

1986 • 117 citations

Immunological evidence for two physiological forms of protein kinase C.

1987 • 104 citations

Effect of RP51 gene dosage alterations on ribosome synthesis in Saccharomyces cerevisiae.

1985 • 103 citations

Intramolecular cleavage of lexA and phage .lambda. repressors: dependence of kinetics on repressor concentration, pH, temperature, and solvent

1986 • 98 citations

Molecular cloning and structural analysis of murine thymidine kinase genomic and cDNA sequences.

1985 • 96 citations

Regulation of catabolism of microinjected ribonuclease A requires the amino-terminal 20 amino acids.

1983 • 81 citations

Immunogold electron microscopy of phytochrome in Avena: identification of intracellular sites responsible for phytochrome sequestering and enhanced pelletability.

1986 • 77 citations

Proteolysis in eukaryotic cells. Proteinase yscE, a new yeast peptidase.

1984 • 76 citations

Degradation of unassembled α- and β-spectrin by distinct intracellular pathways: Regulation of spectrin topogenesis by β-spectrin degradation

1985 • 70 citations

Computer-assisted predictions of signal peptidase processing sites

1987 • 70 citations

Spermidine mediates degradation of ornithine decarboxylase by a non‐lysosomal, ubiquitin‐independent mechanism

1987 • 69 citations

Self-degradation of heat shock proteins.

1985 • 68 citations

Transfer RNA is an essential component of the ubiquitin- and ATP-dependent proteolytic system.

1985 • 62 citations

Phosphorylation of histidine in proteins by a nuclear extract of Physarum polycephalum plasmodia.

1985 • 55 citations

A serine protease activity in C3H/10T1/2 cells that is inhibited by anticarcinogenic protease inhibitors.

1987 • 54 citations

The molybdate-stabilized glucocorticoid binding complex of L-cells contains a 98–100 kdalton steroid binding phosphoprotein and a 90 kdalton nonsteroid-binding phosphoprotein that is part of the murine heat-shock complex

1986 • 52 citations

Post-translational modification of proteins catalyzed by aminoacyl-tRNA-protein transferases

1973 • 49 citations

Turnover of excess hemoglobin alpha chains in beta-thalassemic cells is ATP-dependent.

1983 • 47 citations

The quaternary structure of carp muscle alkaline protease

1980 • 46 citations

Genetic and physical analysis of the chicken tk gene.

1984 • 45 citations

Covalent linkage of ribonuclease S-peptide to microinjected proteins causes their intracellular degradation to be enhanced during serum withdrawal.

1986 • 45 citations

Amino acid sequence of the phosphorylation site of yeast (Saccharomyces cerevisiae) fructose-1,6-bisphosphatase.

1986 • 42 citations

Inhibition of lysosomal protein degradation inhibits the basal degradation of 3-hydroxy-3-methylglutaryl coenzyme A reductase.

1987 • 40 citations

The chicken thymidine kinase gene is transcriptionally repressed during terminal differentiation: The associated decline in TK mRNA cannot account fully for the disappearance of TK enzyme activity

1987 • 34 citations

Location of the phosphorylation site for casein kinase-2 within the amino acid sequence of ornithine decarboxylase

1987 • 31 citations

Metallothionein turnover in mammalian cells. Implications in metal toxicity.

1986 • 27 citations

Regulation of cAMP-Dependent Protein Kinase in Cultured Cells

1985 • 26 citations

Degradation of proteins microinjected into HeLa cells. The role of substrate flexibility.

1986 • 23 citations

Polyomavirus major capsid protein VP1 is modified by tyrosine sulfuration

1987 • 19 citations

The positive transcription factor of the 5S RNA gene proteolyses during direct exchange between 5S DNA sites.

1986 • 11 citations

Precursors of mitochondrial proteins are degraded in the cytosol at different rates

1986 • 6 citations

Do myc, fos and E1A function as protein phosphatase inhibitors?

1987 • 6 citations

Deleted Work

1955 • 0 citations