Cellular phenotypes of age-associated skeletal muscle mitochondrial abnormalities in rhesus monkeys

Sequence and organization of the human mitochondrial genome

1981 • 9,348 citations

Aging: A Theory Based on Free Radical and Radiation Chemistry

1956 • 8,252 citations

Mitochondrial Diseases in Man and Mouse

1999 • 3,008 citations

What is the cause of the ageing atrophy?

1988 • 2,004 citations

Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies

1988 • 1,806 citations

Mitochondrial role in cell aging

1980 • 919 citations

Muscle Architecture of the Human Lower Limb

1983 • 914 citations

NONDROPLET ULTRASTRUCTURAL DEMONSTRATION OF CYTOCHROME OXIDASE ACTIVITY WITH A POLYMERIZING OSMIOPHILIC REAGENT, DIAMINOBENZIDINE (DAB)

1968 • 892 citations

Detection of a specific mitochondrial DNA deletion in tissues of older humans

1990 • 784 citations

A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues.

1992 • 633 citations

Distribution of wild-type and common deletion forms of mtDNA in normal and respiration-deficient muscle fibers from patients with mitochondrial myopathy

1994 • 298 citations

Oxidative capacity of human muscle fiber types: effects of age and training status

1995 • 285 citations

Role of mitochondrial DNA mutations in human aging: Implications for the central nervous system and muscle

1998 • 285 citations

Cytochrome c oxidase deficient fibres in the limb muscle and diaphragm of man without muscular disease: An age-related alteration

1990 • 276 citations

Deletion mutants are functionally dominant over wild-type mitochondrial genomes in skeletal muscle fiber segments in mitochondrial disease

1990 • 248 citations

Free radical theory of aging: Consequences of mitochondrial aging

1983 • 239 citations

Detection of "deleted" mitochondrial genomes in cytochrome-c oxidase-deficient muscle fibers of a patient with Kearns-Sayre syndrome.

1989 • 212 citations

The Influence of Aging on Muscle Strength and Muscle Fiber Characteristics With Special Reference to Eccentric Strength

1995 • 204 citations

Different in situ hybridization patterns of mitochondrial DNA in cytochrome c oxidase-deficient extraocular muscle fibres in the elderly

1993 • 171 citations

Mitochondrial gene mutation: the ageing process and degenerative diseases.

1990 • 166 citations

Molecular analysis of the muscle pathology associated with mitochondrial DNA deletions

1992 • 166 citations

Multiple Deletions Are Detectable in Mitochondrial DNA of Aging Mice

1995 • 159 citations

Ragged Red Fibers in Normal Aging and Inflammatory Myopathy

1995 • 146 citations

Effects of physical activity and age on mitochondrial function

1996 • 134 citations

High levels of mitochondrial DNA deletions in skeletal muscle of old rhesus monkeys

1995 • 123 citations

A Metachromatic Dye-Atpase Method for The Simultaneous Identification of Skeletal Muscle Fiber Types I, IIA, IIB and IIC

1990 • 121 citations

Association of age-related mitochondrial abnormalities with skeletal muscle fiber atrophy

1998 • 120 citations

Multiple Mitochondrial DNA Deletions Associated With Age in Skeletal Muscle of Rhesus Monkeys

1993 • 114 citations

Progressive loss of cytochrome c oxidase in the human extraocular muscles in ageing — a cytochemical-immunohistochemical study

1992 • 111 citations

Progressive cytochrome c oxidase deficiency in a case of earns‐sayre syndrome: Morphological, immunological, and biochemical studies in muscle biopsies and autopsy tissues

1987 • 95 citations

Scanning electron-microscopic studies on the three-dimensional structure of mitochondria in the mammalian red, white and intermediate muscle fibers

1985 • 92 citations

Histological and histochemical stains and reactions

2007 • 91 citations

Focal deficiency of cytochrome-c-oxidase in skeletal muscle of patients with progressive external ophthalmoplegia

1983 • 83 citations

Age-Associated Alterations of the Mitochondrial Genome

1997 • 77 citations

Multiple age-associated mitochondrial DNA deletions in skeletal muscle of mice

1994 • 69 citations

Mitochondrial DNA deletions and cytochrome c oxidase deficiency in muscle fibres

1992 • 62 citations

A MOLECULAR GENETIC STUDY OF FOCAL HISTOCHEMICAL DEFECTS IN MITOCHONDRIAL ENCEPHALOMYOPATHIES

1992 • 56 citations

Immunocytochemical studies of cytochrome oxidase subunits in skeletal muscle of patients with partial cytochrome oxidase deficiencies

1988 • 52 citations

Multiple, large deletions in rat mitochondrial DNA: evidence for a major hot spot

1996 • 50 citations

Skeletal muscle pathology in chronic progressive external ophthalmoplegia with ragged-red fibers

1988 • 49 citations

Cytochrome c oxidase deficiencies in the muscle of patients with inflammatory myopathies

1996 • 44 citations

Respiratory chain failure in adult muscle fibres: relationship with ageing and possible implications for the neuronal pool

1992 • 40 citations

Enzyme activity measured in single muscle fibers in partial cytochrome c oxidase deficiency

1988 • 34 citations

Direct repeat sequences are not required at the breakpoints of age-associated mitochondrial DNA deletions in rhesus monkeys

1994 • 33 citations

Mitochondrial genome distribution in histochemically cytochrome c oxidase-negative muscle fibres in patients with a mixture of deleted and wild type mitochondrial DNA

1991 • 27 citations

Architectural and Fiber Type Distribution Properties of Selected Rhesus Leg Muscles: Feasibility of Multiple Independent Biopsies

1991 • 27 citations

Contrasting histochemical features of various mitochondrial syndromes

1995 • 20 citations

Mosaicism of mitochondria in mitochondrial myopathy: an electronmicroscopic analysis of cytochrome c oxidase

1990 • 19 citations

Neurotrophin‐4 is up‐regulated in ragged‐red fibers associated with pathogenic mitochondrial DNA mutations

1998 • 19 citations

Mitochondrial myopathy: correlation between oxidative defect and mitochondrial DNA deletions at single fiber level

1994 • 19 citations

Molecular histology of mitochondrial and nuclear transcripts in the muscle of patients harbouring a single mitochondrial DNA deletion

1995 • 7 citations

“All‐or‐none” cytochrome C oxidase positivity in mitochondria in chronic progressive external ophthalmoplegia: An ultrastructural—cytochemical study

1993 • 6 citations

Chronic progressive external ophthalmoplegia in patients with large heteroplasmic mitochondrial DNA deletions: an immunocytochemical study

1991 • 6 citations

Deleted Work

1955 • 0 citations