Molecular histology of mitochondrial and nuclear transcripts in the muscle of patients harbouring a single mitochondrial DNA deletion

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

1988 • 17,059 citations

Sequence and organization of the human mitochondrial genome

1981 • 9,348 citations

Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies

1988 • 1,806 citations

Maternal inheritance of human mitochondrial DNA.

1980 • 1,327 citations

NONDROPLET ULTRASTRUCTURAL DEMONSTRATION OF CYTOCHROME OXIDASE ACTIVITY WITH A POLYMERIZING OSMIOPHILIC REAGENT, DIAMINOBENZIDINE (DAB)

1968 • 892 citations

Deletions of mitochondrial DNA in Kearns‐Sayre syndrome

1988 • 730 citations

Maternally transmitted diabetes and deafness associated with a 10.4 kb mitochondrial DNA deletion

1992 • 612 citations

Rapid examination of muscle tissue

1963 • 582 citations

A Direct Repeat Is a Hotspot for Large-Scale Deletion of Human Mitochondrial DNA

1989 • 566 citations

EFFECTS OF COENZYME Q₁₀ AND MENADIONE ON SUCCINIC DEHYDROGENASE ACTIVITY AS MEASURED BY TETRAZOLIUM SALT REDUCTION

1960 • 301 citations

Distribution of wild-type and common deletion forms of mtDNA in normal and respiration-deficient muscle fibers from patients with mitochondrial myopathy

1994 • 298 citations

Detection of "deleted" mitochondrial genomes in cytochrome-c oxidase-deficient muscle fibers of a patient with Kearns-Sayre syndrome.

1989 • 212 citations

Widespread tissue distribution of mitochondrial DNA deletions in Kearns‐Sayre syndrome

1990 • 152 citations

Transcription and translation of deleted mitochondrial genomes in Kearns-Sayre syndrome: implications for pathogenesis.

1990 • 135 citations

Separate nuclear genes encode sarcomere-specific and ubiquitous human mitochondrial creatine kinase isoenzymes.

1990 • 112 citations

Mitochondrial DNA expression in mitochondrial myopathies and coordinated expression of nuclear genes involved in ATP production

1993 • 109 citations

Transcriptional control of nuclear genes for the mitochondrial muscle ADP/ATP translocator and the ATP synthase beta subunit. Multiple factors interact with the OXBOX/REBOX promoter sequences.

1992 • 105 citations

Mitochondrial creatine kinase: a major constituent of pathological inclusions seen in mitochondrial myopathies.

1994 • 90 citations

Regulation of mitochondrial gene expression in mammalian cells

1990 • 62 citations

Mitochondrial DNA deletions and cytochrome c oxidase deficiency in muscle fibres

1992 • 62 citations

Analysis of viral infections by in situ hybridization.

1986 • 57 citations

A MOLECULAR GENETIC STUDY OF FOCAL HISTOCHEMICAL DEFECTS IN MITOCHONDRIAL ENCEPHALOMYOPATHIES

1992 • 56 citations

Brain Structures Selectively Targeted by Canine Distemper Virus in a Mouse Model Infection

1993 • 50 citations

Lack of transmission of deleted mtDNA from a woman with Kearns-Sayre syndrome to her child.

1992 • 50 citations

Skeletal muscle pathology in chronic progressive external ophthalmoplegia with ragged-red fibers

1988 • 49 citations

Replication-competent human mitochondrial DNA lacking the heavy-strand promoter region.

1991 • 46 citations

In situ hybridization of mitochondrial DNA in the heart of a patient with Kearns-Sayre syndrome and dilatative cardiomyopathy

1992 • 41 citations

Different copy numbers of apparently identically deleted mitochondrial DNA in tissues from a patient with Kearns-Sayre syndrome detected by PCR

1990 • 38 citations

Decreased expression o ubiquinol-cytochrome c reductase subunits in patients exhibiting mitochondrial myopathy with progressive exercise intolerance

1993 • 32 citations

Mitochondrial genome distribution in histochemically cytochrome c oxidase-negative muscle fibres in patients with a mixture of deleted and wild type mitochondrial DNA

1991 • 27 citations

Mitochondrial myopathy: correlation between oxidative defect and mitochondrial DNA deletions at single fiber level

1994 • 19 citations

Molecular insight into the asymmetric distribution of pathogenetic human mitochondrial DNA deletions

1991 • 16 citations

In situ hybridization of muscle mitochondrial mRNA in mitochondrial myopathies

1990 • 9 citations

Developmental expression of tryptophan hydroxylase mRNAs in the rat pineal gland: an in situ hybridization study

1995 • 8 citations