Somatostatin Activation of Mitogen-Activated Protein Kinase via Somatostatin Receptor 1 (SSTR1)

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

p21 is a universal inhibitor of cyclin kinases

1993 • 3,408 citations

A synthetic inhibitor of the mitogen-activated protein kinase cascade.

1995 • 2,723 citations

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

1994 • 1,999 citations

Growth factor signaling by receptor tyrosine kinases

1992 • 1,450 citations

Identification of a Member of the MAPKKK Family as a Potential Mediator of TGF-β Signal Transduction

1995 • 1,318 citations

The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain

1993 • 1,313 citations

cAMP Activates MAP Kinase and Elk-1 through a B-Raf- and Rap1-Dependent Pathway

1997 • 1,047 citations

The Role of Somatostatin and Its Analogs in the Diagnosis and Treatment of Tumors

1991 • 827 citations

Ras-dependent activation of MAP kinase pathway mediated by G-protein βγ subunits

1994 • 814 citations

Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney.

1992 • 766 citations

Linkage of G Protein-Coupled Receptors to the MAPK Signaling Pathway Through PI 3-Kinase γ

1997 • 671 citations

Raf-Induced Proliferation or Cell Cycle Arrest Is Determined by the Level of Raf Activity with Arrest Mediated by p21^Cip1

1997 • 643 citations

The complexity of Raf-1 regulation

1997 • 633 citations

Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation.

1995 • 609 citations

Raf meets Ras: completing the framework of a signal transduction pathway

1994 • 591 citations

Motheaten and viable motheaten mice have mutations in the haematopoietic cell phosphatase gene

1993 • 578 citations

Classification and nomenclature of somatostatin receptors

1995 • 573 citations

Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway

1995 • 541 citations

Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2

1997 • 474 citations

Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1

1998 • 468 citations

High-Intensity Raf Signal Causes Cell Cycle Arrest Mediated by p21^Cip1

1997 • 464 citations

Cell transformation and activation of pp60c-src by overexpression of a protein tyrosine phosphatase

1992 • 455 citations

Ras-dependent Mitogen-activated Protein Kinase Activation by G Protein-coupled Receptors

1997 • 454 citations

Serum-, TPA-, and Ras-induced expression from Ap-1/Ets-driven promoters requires Raf-1 kinase.

1992 • 453 citations

Direct evidence that Gi-coupled receptor stimulation of mitogen-activated protein kinase is mediated by G beta gamma activation of p21ras.

1994 • 418 citations

Disruption of the csk gene, encoding a negative regulator of Src family tyrosine kinases, leads to neural tube defects and embryonic lethality in mice

1993 • 394 citations

Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras.

1994 • 389 citations

Phosphatidylinositol 3-Kinase Is an Early Intermediate in the Gβγ-mediated Mitogen-activated Protein Kinase Signaling Pathway

1996 • 372 citations

Characterization of hematopoietic intracellular protein tyrosine phosphatases: description of a phosphatase containing an SH2 domain and another enriched in proline-, glutamic acid-, serine-, and threonine-rich sequences.

1992 • 367 citations

Stimulation of tyrosine phosphatase and inhibition of cell proliferation by somatostatin analogues: mediation by human somatostatin receptor subtypes SSTR1 and SSTR2.

1994 • 329 citations

Binding of Shp2 Tyrosine Phosphatase to FRS2 Is Essential for Fibroblast Growth Factor-Induced PC12 Cell Differentiation

1998 • 322 citations

Molecular biology of somatostatin receptors

1993 • 311 citations

Expression of catalytically inactive Syp phosphatase in 3T3 cells blocks stimulation of mitogen-activated protein kinase by insulin.

1994 • 302 citations

Characterization of functional receptors for somatostatin in rat pituitary cells in culture.

1978 • 290 citations

Somatostatin receptors in human endocrine tumors.

1987 • 253 citations

Syp (SH-PTP2) is a positive mediator of growth factor-stimulated mitogenic signal transduction.

1994 • 240 citations

A Novel Mitogen-activated Protein Kinase Phosphatase. STRUCTURE, EXPRESSION, AND REGULATION

1995 • 233 citations

A Role for Mitogen-Activated Protein Kinase in Mediating Activation of the Glycoprotein Hormone α-Subunit Promoter by Gonadotropin-Releasing Hormone

1995 • 224 citations

G Protein Activation of a Hormone-Stimulated Phosphatase in Human Tumor Cells

1992 • 206 citations

Reversal of Raf-1 Activation by Purified and Membrane-Associated Protein Phosphatases

1995 • 202 citations

Expression cloning of a rat brain somatostatin receptor cDNA.

1992 • 201 citations

Phosphorylation of Raf-1 Serine 338-Serine 339 Is an Essential Regulatory Event for Ras-Dependent Activation and Biological Signaling

1997 • 196 citations

G Protein-Coupled Receptor Systems Involved in Cell Growth and Oncogenesis

1995 • 196 citations

Conditional Inhibition of the Mitogen-activated Protein Kinase Cascade by Wortmannin

1997 • 196 citations

G Protein-coupled Chemoattractant Receptors Regulate Lyn Tyrosine Kinase·Shc Adapter Protein Signaling Complexes

1995 • 185 citations

Gβγ interactions with PH domains and Ras-MAPK signaling pathways

1995 • 177 citations

Lack of SHPTP1 results in src-family kinase hyperactivation and thymocyte hyperresponsiveness.

1996 • 174 citations

Dephosphorylation and inactivation of the mitogen-activated protein kinase by a mitogen-induced Thr/Tyr protein phosphatase

1993 • 170 citations

The Tyrosine Phosphatase SHP-1 Associates with the sst2 Somatostatin Receptor and Is an Essential Component of sst2-mediated Inhibitory Growth Signaling

1997 • 168 citations

Dominant inhibitory Ras mutants selectively inhibit the activity of either cellular or oncogenic Ras.

1991 • 164 citations

Localization of insulin-like growth factor I and inhibition of coronary smooth muscle cell growth by somatostatin analogues in human coronary smooth muscle cells. A potential treatment for restenosis?

1994 • 163 citations

Src Kinase Activity Is Regulated by the SHP-1 Protein-tyrosine Phosphatase

1997 • 162 citations

B-Raf-dependent regulation of the MEK-1/mitogen-activated protein kinase pathway in PC12 cells and regulation by cyclic AMP.

1994 • 157 citations

Nerve Growth Factor Induces Transcription of the p21 WAF1/CIP1 and Cyclin D1 Genes in PC12 Cells by Activating the Sp1 Transcription Factor

1997 • 156 citations

Stimulation by somatostatin of dephosphorylation of membrane proteins in pancreatic cancer MIA PaCa‐2 cell line

1985 • 138 citations

Ras-Induced Activation of Raf-1 Is Dependent on Tyrosine Phosphorylation

1996 • 131 citations

Structure and function of SH2-domain containing tyrosine phosphatases

1993 • 118 citations

Distribution and second messenger coupling of four somatostatin receptor subtypes expressed in brain

1993 • 117 citations

Ras-Dependent Activation of Fibroblast Mitogen-Activated Protein Kinase by 5-HT_1A Receptor via a G Protein βγ-Subunit-Initiated Pathway

1996 • 99 citations

Effects of epidermal growth factor and analogues of luteinizing hormone-releasing hormone and somatostatin on phosphorylation and dephosphorylation of tyrosine residues of specific protein substrates in various tumors.

1991 • 99 citations

Somatostatin-14 and its analog octreotide exert a cytostatic effect on GH3 rat pituitary tumor cell proliferation via a transient G0/G1 cell cycle block.

1995 • 94 citations

The Phosphotyrosine Phosphatase PTP1D, but not PTP1C, Is an Essential Mediator of Fibroblast Proliferation Induced by Tyrosine Kinase and G Protein-coupled Receptors

1995 • 93 citations

The somatostatin receptor SSTR1 is coupled to phosphotyrosine phosphatase activity in CHO-K1 cells.

1994 • 91 citations

Biochemical and Functional Properties of Somatostatin Receptors

1992 • 85 citations

ActivationIn Vitroof Somatostatin Receptor Subtypes 2, 3, or 4 Stimulates Protein Tyrosine Phosphatase Activity in Membranes from Transfected Ras-Transformed NIH 3T3 Cells: Coexpression with Catalytically Inactive SHP-2 Blocks Responsiveness

1997 • 82 citations

Regulation of the Src tyrosine kinase and Syp tyrosine phosphatase by their cellular association.

1995 • 80 citations

Identification of the functional components of the Ras signaling pathway regulating pituitary cell-specific gene expression.

1994 • 74 citations

Somatostatin Inhibits PC Cl3 Thyroid Cell Proliferation through the Modulation of Phosphotyrosine Phosphatase Activity

1996 • 71 citations

Octapeptide somatostatin analog SMS 201-995 induces translocation of intracellular PTP1C to membranes in MCF-7 human breast adenocarcinoma cells.

1996 • 70 citations

SMS 201.995 inhibits in vitro and in vivo growth of human colon cancer.

1992 • 64 citations

A role for the SHP-2 tyrosine phosphatase in nerve growth-induced PC12 cell differentiation.

1997 • 61 citations

Somatostatin Inhibits Deoxyribonucleic Acid Synthesis Induced by Both Thyrotropin and Insulin-Like Growth Factor-I in FRTL5 Cells*

1990 • 59 citations

A somatostatin analogue inhibits MAP kinase activation and cell proliferation in human neuroblastoma and in human small cell lung carcinoma cell lines

1996 • 59 citations

Inhibition of an Inward Rectifier Potassium Channel (Kir2.3) by G-protein βγ Subunits

1996 • 58 citations

On the Mechanism of Cytosolic Phospholipase A2 Activation in CHO Cells Carrying Somatostatin Receptor: Wortmannin-Sensitive Pathway to Activate Mitogen-Activated Protein Kinase

1994 • 52 citations

Regulation of luteinizing hormone-releasing hormone receptor binding by heterologous and autologous receptor-stimulated tyrosine phosphorylation.

1991 • 52 citations

Growth of Human Breast Cancer Cell Lines Is Inhibited by the Somatostatin Analog BIM23014*

1991 • 51 citations

Activation of a protein tyrosine phosphatase and inactivation of Raf-1 by somatostatin

1996 • 48 citations

Co-purification of a protein tyrosine phosphatase with activated somatostatin receptors from rat pancreatic acinar membranes

1994 • 47 citations

Somatostatin Acts by Inhibiting the Cyclic 3′,5′-Adenosine Monophosphate (cAMP)/Protein Kinase A Pathway, cAMP Response Element-Binding Protein (CREB) Phosphorylation, and CREB Transcription Potency

1997 • 45 citations

The somatostatin receptors SSTR1 and SSTR2 are coupled to inhibition of adenylyl cyclase in Chinese hamster ovary cells via pertussis toxin-sensitive pathways.

1994 • 43 citations

Regulation of mitogen-activated protein kinase in the pars tuberalis of the ovine pituitary: interactions between melatonin, insulin-like growth factor-1, and forskolin.

1996 • 43 citations

Both Overlapping and Distinct Signaling Pathways for Somatostatin Receptor Subtypes SSTR1 and SSTR2 in Pituitary Cells

1997 • 36 citations

Development and use of a receptor antibody to characterize the interaction between somatostatin receptor subtype 1 and G proteins.

1995 • 36 citations

Inactivation of Raf-1 by a Protein-tyrosine Phosphatase Stimulated by GTP and Reconstituted by Gαi/o Subunits

1996 • 35 citations

Octapeptide analogues of somatostatin inhibit the clonal growth and vasoactive intestinal peptide-stimulated cyclic AMP formation in human small cell lung cancer cells

1991 • 33 citations

Somatostatin analogue rc‐160 inhibits the growth of transplanted colon cancer in rats

1991 • 31 citations

Regulation of luteinizing hormone-releasing hormone receptor binding by heterologous receptorstimulated tyrosine phosphorylation

1991 • 22 citations

Oncogene Transformation of PC Cl3 Clonal Thyroid Cell Line Induces an Autonomous Pattern of Proliferation That Correlates with a Loss of Basal and Stimulated Phosphotyrosine Phosphatase Activity*

1997 • 21 citations

Reduced tyrosine kinase specific activity is associated with hypophosphorylation of pp60c-src in cells infected with avian erythroblastosis virus.

1987 • 9 citations