Src Kinase Activity Is Regulated by the SHP-1 Protein-tyrosine Phosphatase

Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals

1995 • 956 citations

Activation and suppression of pp60c-src transforming ability by mutation of its primary sites of tyrosine phosphorylation

1987 • 648 citations

Tyr ⁵²⁷ Is Phosphorylated in pp60 ^{c- src} : Implications for Regulation

1986 • 567 citations

The when and how of Src regulation

1993 • 543 citations

CSK: a protein-tyrosine kinase involved in regulation of src family kinases.

1991 • 522 citations

Isolation of monoclonal antibodies that recognize the transforming proteins of avian sarcoma viruses

1983 • 518 citations

Expression of CD45 alters phosphorylation of the lck-encoded tyrosine protein kinase in murine lymphoma T-cell lines.

1989 • 465 citations

Cell transformation and activation of pp60c-src by overexpression of a protein tyrosine phosphatase

1992 • 455 citations

Activation of the pp60c-src kinase by middle T antigen binding or by dephosphorylation.

1985 • 439 citations

Cell transformation by pp60c-src mutated in the carboxy-terminal regulatory domain

1987 • 410 citations

A protein-tyrosine phosphatase with sequence similarity to the SH2 domain of the protein-tyrosine kinases

1991 • 401 citations

Disruption of the csk gene, encoding a negative regulator of Src family tyrosine kinases, leads to neural tube defects and embryonic lethality in mice

1993 • 394 citations

Direct Regulation of ZAP-70 by SHP-1 in T Cell Antigen Receptor Signaling

1996 • 390 citations

Characterization of hematopoietic intracellular protein tyrosine phosphatases: description of a phosphatase containing an SH2 domain and another enriched in proline-, glutamic acid-, serine-, and threonine-rich sequences.

1992 • 367 citations

Protein tyrosine phosphatase containing SH2 domains: characterization, preferential expression in hematopoietic cells, and localization to human chromosome 12p12-p13.

1992 • 349 citations

The human p50csk tyrosine kinase phosphorylates p56lck at Tyr-505 and down regulates its catalytic activity.

1992 • 320 citations

Isolation of a src homology 2-containing tyrosine phosphatase.

1992 • 304 citations

Direct Association with and Dephosphorylation of Jak2 Kinase by the SH2-Domain-Containing Protein Tyrosine Phosphatase SHP-1

1996 • 291 citations

Association of hematopoietic cell phosphatase with c-Kit after stimulation with c-Kit ligand.

1993 • 267 citations

Dephosphorylation or antibody binding to the carboxy terminus stimulates pp60c-src.

1986 • 257 citations

Protein kinase C phosphorylates pp60src at a novel site

1985 • 243 citations

Expression and catalytic activity of the tyrosine phosphatase PTP1C is severely impaired in motheaten and viable motheaten mice.

1993 • 243 citations

Receptor protein tyrosine phosphatase alpha activates pp60c-src and is involved in neuronal differentiation.

1993 • 237 citations

Redistribution of activated pp60c-src to integrin-dependent cytoskeletal complexes in thrombin-stimulated platelets.

1993 • 219 citations

Intramolecular Regulation of Protein Tyrosine Phosphatase SH-PTP1: A New Function for Src Homology 2 Domains

1994 • 207 citations

Characterization of pp60c-src Tyrosine Kinase Activities Using a Continuous Assay: Autoactivation of the Enzyme Is an Intermolecular Autophosphorylation Process

1995 • 192 citations

Effects of SH2 and SH3 deletions on the functional activities of wild-type and transforming variants of c-Src.

1992 • 179 citations

Regulation of the p59^fyn protein tyrosine kinase by the CD45 phosphotyrosine phosphatase

1992 • 179 citations

Differential effects of expression of the CD45 tyrosine protein phosphatase on the tyrosine phosphorylation of the lck, fyn, and c-src tyrosine protein kinases.

1993 • 179 citations

Selective binding of activated pp60c-src by an immobilized synthetic phosphopeptide modeled on the carboxyl terminus of pp60c-src.

1991 • 175 citations

Lack of SHPTP1 results in src-family kinase hyperactivation and thymocyte hyperresponsiveness.

1996 • 174 citations

Monoclonal antibodies to Rous sarcoma virus pp60src react with enzymatically active cellular pp60src of avian and mammalian origin

1984 • 163 citations

Interleukin 2-induced tyrosine phosphorylation. Interleukin 2 receptor beta is tyrosine phosphorylated.

1990 • 149 citations

Differential functions of the two Src homology 2 domains in protein tyrosine phosphatase SH-PTP1.

1996 • 142 citations

Identification and characterization of cellular targets for tyrosine protein kinases.

1983 • 139 citations

Phosphopeptide mapping and phosphoamino acid analysis by electrophoresis and chromatography on thin‐layer cellulose plates

1994 • 138 citations

Insulin stimulates the phosphorylation of Tyr538 and the catalytic activity of PTP1C, a protein tyrosine phosphatase with Src homology-2 domains.

1994 • 129 citations

Enzymatically inactive p60c-src mutant with altered ATP-binding site is fully phosphorylated in its carboxy-terminal regulatory region

1987 • 117 citations

Modulation of the SH2 Binding Specificity and Kinase Activity of Src by Tyrosine Phosphorylation within Its SH2 Domain

1996 • 91 citations

A New Monoclonal Antibody Which Selectively Recognizes the Active Form of Src Tyrosine Kinase

1996 • 87 citations

Analysis of pp60c-src in human colon carcinoma and normal human colon mucosal cells.

1987 • 87 citations

Deletion of the SH3 domain of Src interferes with regulation by the phosphorylated carboxyl-terminal tyrosine.

1993 • 85 citations

Regulation of the Src tyrosine kinase and Syp tyrosine phosphatase by their cellular association.

1995 • 80 citations

Positive Effect of Overexpressed Protein-tyrosine Phosphatase PTP1C on Mitogen-activated Signaling in 293 Cells

1996 • 69 citations

Tyrosine phosphorylation of an SH2-containing protein tyrosine phosphatase is coupled to platelet thrombin receptor via a pertussis toxin-sensitive heterotrimeric G-protein.

1995 • 68 citations

Autophosphorylation of Purified c-Src at its Primary Negative Regulation Site

1995 • 58 citations

Investigation of factors that influence phosphorylation of pp60c-src on tyrosine 527.

1988 • 54 citations

Comparative study of three protein-tyrosine phosphatases. Chicken protein-tyrosine phosphatase lambda dephosphorylates c-Src tyrosine 527.

1994 • 43 citations

Association of the protein tyrosine phosphatase PTP1C with the protein tyrosine kinase c‐Src in human platelets

1996 • 38 citations

pp60c-src expression is induced by activation of normal human T lymphocytes.

1995 • 38 citations

Src Kinase Tyrosine Phosphorylates PTP1C, a Protein Tyrosine Phosphatase Containing Src Homology-2 Domains That Down-Regulates Cell Proliferation

1994 • 32 citations

Neither the LCK nor the FYN kinases are obligatory for IL-2-mediated signal transduction in HTLV-l-infected human T cells

1992 • 31 citations