Integrating mechanisms of pulmonary fibrosis

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

2006 • 6,720 citations

A role for mitochondria in NLRP3 inflammasome activation

2010 • 4,672 citations

IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

2005 • 3,961 citations

Complex networks orchestrate epithelial–mesenchymal transitions

2006 • 3,818 citations

IL-33, an Interleukin-1-like Cytokine that Signals via the IL-1 Receptor-Related Protein ST2 and Induces T Helper Type 2-Associated Cytokines

2005 • 3,466 citations

Transforming Growth Factor β in Tissue Fibrosis

1994 • 3,055 citations

MicroRNA-21 Regulates Expression of the PTEN Tumor Suppressor Gene in Human Hepatocellular Cancer

2007 • 2,677 citations

MicroRNA-21 Is an Antiapoptotic Factor in Human Glioblastoma Cells

2005 • 2,530 citations

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

2008 • 2,505 citations

MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts

2008 • 2,222 citations

MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer

2007 • 1,818 citations

Idiopathic Pulmonary Fibrosis: Prevailing and Evolving Hypotheses about Its Pathogenesis and Implications for Therapy

2001 • 1,727 citations

Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production

1999 • 1,715 citations

Fibrotic disease and the TH1/TH2 paradigm

2004 • 1,623 citations

Requirement of Interleukin 17 Receptor Signaling for Lung Cxc Chemokine and Granulocyte Colony-Stimulating Factor Expression, Neutrophil Recruitment, and Host Defense

2001 • 1,505 citations

Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases

2007 • 1,380 citations

Regulation of lung injury and repair by Toll-like receptors and hyaluronan

2005 • 1,360 citations

Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair

2005 • 1,351 citations

Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair

2005 • 1,339 citations

Macrophages: Master Regulators of Inflammation and Fibrosis

2010 • 1,226 citations

IL-25 Induces IL-4, IL-5, and IL-13 and Th2-Associated Pathologies In Vivo

2001 • 1,159 citations

MicroRNA-21 Targets the Tumor Suppressor Gene Tropomyosin 1 (TPM1)

2007 • 1,077 citations

MicroRNA-21 targets tumor suppressor genes in invasion and metastasis

2008 • 1,002 citations

Interleukin 1 receptor antagonist mediates the antiinflammatory and antifibrotic effect of mesenchymal stem cells during lung injury

2007 • 993 citations

Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis

2004 • 953 citations

High-Dose Acetylcysteine in Idiopathic Pulmonary Fibrosis

2005 • 927 citations

Interleukin-13 Induces Tissue Fibrosis by Selectively Stimulating and Activating Transforming Growth Factor β1

2001 • 896 citations

Reactive oxygen species (ROS) and reactive nitrogen species (RNS) generation by silica in inflammation and fibrosis

2003 • 878 citations

Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis

2004 • 868 citations

miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis

2010 • 858 citations

MicroRNA-21 targets tumor suppressor genes in invasion and metastasis

2008 • 854 citations

The Nalp3 inflammasome is essential for the development of silicosis

2008 • 844 citations

Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ

2007 • 817 citations

Acidic Mammalian Chitinase in Asthmatic Th2 Inflammation and IL-13 Pathway Activation

2004 • 809 citations

Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice

2005 • 795 citations

NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injury

2009 • 777 citations

Arginase-1–Expressing Macrophages Suppress Th2 Cytokine–Driven Inflammation and Fibrosis

2009 • 768 citations

The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak

2007 • 740 citations

Murine models of pulmonary fibrosis

2007 • 726 citations

Transient expression of IL-1β induces acute lung injury and chronic repair leading to pulmonary fibrosis

2001 • 720 citations

Mechanisms of Pulmonary Fibrosis

2004 • 714 citations

Mitochondrial reactive oxygen species drive proinflammatory cytokine production

2011 • 710 citations

Aberrant Wnt/β-Catenin Pathway Activation in Idiopathic Pulmonary Fibrosis

2003 • 663 citations

Bleomycin and IL-1β–mediated pulmonary fibrosis is IL-17A dependent

2010 • 655 citations

An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2–dominated inflammatory response

1999 • 601 citations

Gene expression analysis reveals matrilysin as a key regulator of pulmonary fibrosis in mice and humans

2002 • 600 citations

Bleomycins: towards better therapeutics

2005 • 600 citations

Methylation determines fibroblast activation and fibrogenesis in the kidney

2010 • 584 citations

Requirement of tumour necrosis factor for development of silica-induced pulmonary fibrosis

1990 • 581 citations

The radiotherapeutic injury – a complex ‘wound’

2002 • 573 citations

WNT1-inducible signaling protein–1 mediates pulmonary fibrosis in mice and is upregulated in humans with idiopathic pulmonary fibrosis

2009 • 523 citations

Interleukin-1β and Tumor Necrosis Factor-α Decrease Collagen Synthesis and Increase Matrix Metalloproteinase Activity in Cardiac Fibroblasts In Vitro

2000 • 486 citations

Inhibition and Role of let-7d in Idiopathic Pulmonary Fibrosis

2010 • 477 citations

Mechanisms of Fibrogenesis

2008 • 470 citations

Functional Wnt Signaling Is Increased in Idiopathic Pulmonary Fibrosis

2008 • 469 citations

IL-1R1/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice

2007 • 450 citations

A Vicious Circle of Alveolar Macrophages and Fibroblasts Perpetuates Pulmonary Fibrosis via CCL18

2006 • 445 citations

Influence of Alternatively and Classically Activated Macrophages on Fibrogenic Activities of Human Fibroblasts

2000 • 432 citations

CCR2-Mediated Recruitment of Fibrocytes to the Alveolar Space after Fibrotic Injury

2005 • 422 citations

Interleukin-1β Causes Pulmonary Inflammation, Emphysema, and Airway Remodeling in the Adult Murine Lung

2005 • 409 citations

Mortality in rheumatoid arthritis

1995 • 407 citations

An IL-12-based vaccination method for preventing fibrosis induced by schistosome infection

1995 • 403 citations

Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13–induced tissue responses and apoptosis

2009 • 399 citations

Uric Acid Is a Danger Signal Activating NALP3 Inflammasome in Lung Injury Inflammation and Fibrosis

2009 • 395 citations

Epithelial cell α3β1 integrin links β-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis

2008 • 383 citations

Inhibition of airway remodeling in IL-5–deficient mice

2004 • 374 citations

Expression of a tumor necrosis factor-alpha transgene in murine lung causes lymphocytic and fibrosing alveolitis. A mouse model of progressive pulmonary fibrosis.

1995 • 364 citations

Protection from Pulmonary Fibrosis in the Absence of CCR2 Signaling

2001 • 360 citations

MiR-21 Regulates Adipogenic Differentiation through the Modulation of TGF-β Signaling in Mesenchymal Stem Cells Derived from Human Adipose Tissue

2009 • 356 citations

Phenotypic and physiologic characterization of transgenic mice expressing interleukin 4 in the lung: lymphocytic and eosinophilic inflammation without airway hyperreactivity.

1996 • 355 citations

Treatment of Idiopathic Pulmonary Fibrosis with Etanercept

2008 • 351 citations

Fibroblasts from Idiopathic Pulmonary Fibrosis and Normal Lungs Differ in Growth Rate, Apoptosis, and Tissue Inhibitor of Metalloproteinases Expression

2001 • 348 citations

Mortality in rheumatoid arthritis. Increased in the early course of disease, in ischaemic heart disease and in pulmonary fibrosis

2006 • 334 citations

The IL-21 receptor augments Th2 effector function and alternative macrophage activation

2006 • 333 citations

Enhanced IL-1 beta and tumor necrosis factor-alpha release and messenger RNA expression in macrophages from idiopathic pulmonary fibrosis or after asbestos exposure.

1993 • 329 citations

Serum CC-Chemokine Ligand 18 Concentration Predicts Outcome in Idiopathic Pulmonary Fibrosis

2009 • 307 citations

PPARγ agonists inhibit TGF-β induced pulmonary myofibroblast differentiation and collagen production: implications for therapy of lung fibrosis

2005 • 304 citations

The Role of CCL12 in the Recruitment of Fibrocytes and Lung Fibrosis

2006 • 301 citations

Overlapping and enzyme-specific contributions of matrix metalloproteinases-9 and -12 in IL-13–induced inflammation and remodeling

2002 • 300 citations

Regulation of pulmonary fibrosis by chemokine receptor CXCR3

2004 • 294 citations

Treatment by human recombinant soluble TNF receptor of pulmonary fibrosis induced by bleomycin or silica in mice

1994 • 287 citations

The Role of Inflammation in the Pathogenesis of Idiopathic Pulmonary Fibrosis

2007 • 277 citations

Production of Interleukin 13 by Alveolar Macrophages from Normal and Fibrotic Lung

1998 • 266 citations

Baseline BAL Neutrophilia Predicts Early Mortality in Idiopathic Pulmonary Fibrosis

2007 • 266 citations

Pivotal Advance: Th-1 cytokines inhibit, and Th-2 cytokines promote fibrocyte differentiation

2008 • 264 citations

The role of CXC chemokines in pulmonary fibrosis

2007 • 258 citations

Regulation and Function of the Interleukin 13 Receptor α 2 During a T Helper Cell Type 2–dominant Immune Response

2003 • 252 citations

Overlapping and enzyme-specific contributions of matrix metalloproteinases-9 and -12 in IL-13–induced inflammation and remodeling

2002 • 241 citations

Critical role for the chemokine MCP-1/CCR2 in the pathogenesis of bronchiolitis obliterans syndrome

2001 • 232 citations

Critical Role for CXCR3 Chemokine Biology in the Pathogenesis of Bronchiolitis Obliterans Syndrome

2002 • 230 citations

γδ T cells protect against lung fibrosis via IL-22

2010 • 227 citations

Thy-1 Promoter Hypermethylation

2008 • 225 citations

Dual Roles of IL-4 in Lung Injury and Fibrosis

2003 • 222 citations

IL-13 Is a Key Regulatory Cytokine for Th2 Cell-Mediated Pulmonary Granuloma Formation and IgE Responses Induced bySchistosoma mansoniEggs

1999 • 216 citations

Interaction of IL-13 and C10 in the Pathogenesis of Bleomycin-Induced Pulmonary Fibrosis

2002 • 215 citations

Critical role for the chemokine MCP-1/CCR2 in the pathogenesis of bronchiolitis obliterans syndrome

2001 • 210 citations

IL-33 Induces IL-13–Dependent Cutaneous Fibrosis

2009 • 209 citations

Lung tissues in patients with systemic sclerosis have gene expression patterns unique to pulmonary fibrosis and pulmonary hypertension

2010 • 209 citations

Mfge8 diminishes the severity of tissue fibrosis in mice by binding and targeting collagen for uptake by macrophages

2009 • 199 citations

IL-13-Induced Chemokine Responses in the Lung: Role of CCR2 in the Pathogenesis of IL-13-Induced Inflammation and Remodeling

2002 • 196 citations

Pathological integrin signaling enhances proliferation of primary lung fibroblasts from patients with idiopathic pulmonary fibrosis

2008 • 196 citations

PPAR-γ agonists inhibit profibrotic phenotypes in human lung fibroblasts and bleomycin-induced pulmonary fibrosis

2007 • 194 citations

Protection from Pulmonary Fibrosis in Leukotriene-Deficient Mice

2002 • 193 citations

Interleukin-5 (IL-5) Augments the Progression of Liver Fibrosis by Regulating IL-13 Activity

2006 • 189 citations

PPARs in Diseases: Control Mechanisms of Inflammation

2005 • 189 citations

Anti-IL-13 monoclonal antibody inhibits airway hyperresponsiveness, inflammation and airway remodeling

2004 • 189 citations

Expression and localization of tumor necrosis factor-alpha and its mRNA in idiopathic pulmonary fibrosis.

1993 • 188 citations

Future Research Directions in Idiopathic Pulmonary Fibrosis

2002 • 183 citations

Constitutive activation of 5-lipoxygenase in the lungs of patients with idiopathic pulmonary fibrosis.

1996 • 182 citations

Th17-Polarized Immune Response in a Murine Model of Hypersensitivity Pneumonitis and Lung Fibrosis

2009 • 181 citations

Protection from Fluorescein Isothiocyanate-Induced Fibrosis in IL-13-Deficient, but Not IL-4-Deficient, Mice Results from Impaired Collagen Synthesis by Fibroblasts

2004 • 178 citations

Prostaglandin F2α receptor signaling facilitates bleomycin-induced pulmonary fibrosis independently of transforming growth factor-β

2009 • 177 citations

Involvement of cyclooxygenase-2 and prostaglandins in the molecular pathogenesis of inflammatory lung diseases

2006 • 177 citations

Unique functions of the type II interleukin 4 receptor identified in mice lacking the interleukin 13 receptor α1 chain

2007 • 171 citations

Role of interleukin‐13 in eosinophil accumulation and airway remodelling in a mouse model of chronic asthma

2002 • 171 citations

Adenosine mediates IL-13–induced inflammation and remodeling in the lung and interacts in an IL-13–adenosine amplification pathway

2003 • 166 citations

CXCL11 Attenuates Bleomycin-induced Pulmonary Fibrosis via Inhibition of Vascular Remodeling

2004 • 163 citations

Production and function of murine macrophage inflammatory protein-1 alpha in bleomycin-induced lung injury.

1994 • 161 citations

Adenosine mediates IL-13–induced inflammation and remodeling in the lung and interacts in an IL-13–adenosine amplification pathway

2003 • 160 citations

A pivotal role of cytosolic phospholipase A2 in bleomycin-induced pulmonary fibrosis

2002 • 155 citations

AMERICAN THORACIC SOCIETY; EUROPEAN RESPIRATORY SOCIETY; AMERICAN COLLEGE OF CHEST PHYSICIANS. IDIOPATHIC PULMONARY FIBROSIS: PREVAILING AND EVOLVING HYPOTHESES ABOUT ITS PATHOGENESIS AND IMPLICATIONS FOR THERAPY

2001 • 152 citations

Effect of rosiglitazone and 15-deoxy-Δ^12,14-prostaglandin J₂on bleomycin-induced lung injury

2005 • 149 citations

Inhibition of pulmonary fibrosis in mice by CXCL10 requires glycosaminoglycan binding and syndecan-4

2010 • 149 citations

Hyper-responsiveness of IPF/UIP fibroblasts: Interplay between TGFβ1, IL-13 and CCL2

2008 • 141 citations

Matrix Metalloproteinase 12-Deficiency Augments Extracellular Matrix Degrading Metalloproteinases and Attenuates IL-13–Dependent Fibrosis

2010 • 139 citations

Oxidative Stress, Plasminogen Activator Inhibitor 1, and Lung Fibrosis

2007 • 139 citations

The antifibrotic effects of plasminogen activation occur via prostaglandin E2 synthesis in humans and mice

2010 • 134 citations

IL-13Rα2 and IL-10 coordinately suppress airway inflammation, airway-hyperreactivity, and fibrosis in mice

2007 • 131 citations

A Rearranged Form of Epstein–Barr Virus DNA Is Associated with Idiopathic Pulmonary Fibrosis

2002 • 130 citations

Molecular Basis for Shared Cytokine Recognition Revealed in the Structure of an Unusually High Affinity Complex between IL-13 and IL-13Rα2

2010 • 128 citations

Role of CXCR2/CXCR2 ligands in vascular remodeling during bronchiolitis obliterans syndrome

2005 • 118 citations

Elevated serum tumor necrosis factor-alpha levels in patients with systemic sclerosis: association with pulmonary fibrosis.

1997 • 106 citations

Eosinophils and T Lymphocytes Possess Distinct Roles in Bleomycin-Induced Lung Injury and Fibrosis

2003 • 106 citations

Pivotal Role of CCR1-Positive Leukocytes in Bleomycin- Induced Lung Fibrosis in Mice

2000 • 104 citations

The C10/CCL6 Chemokine and CCR1 Play Critical Roles in the Pathogenesis of IL-13-Induced Inflammation and Remodeling

2004 • 101 citations

Role of CXCR2/CXCR2 ligands in vascular remodeling during bronchiolitis obliterans syndrome

2005 • 100 citations

Integrating the MicroRNome into the Study of Lung Disease

2008 • 99 citations

Repression of IP-10 by Interactions between Histone Deacetylation and Hypermethylation in Idiopathic Pulmonary Fibrosis

2010 • 97 citations

IL-17A-Expressing T Cells Are Essential for Bacterial Clearance in a Murine Model of Hypersensitivity Pneumonitis

2009 • 95 citations

β-Arrestin Deficiency Protects Against Pulmonary Fibrosis in Mice and Prevents Fibroblast Invasion of Extracellular Matrix

2011 • 89 citations

Eosinophils and CCR3 Regulate Interleukin-13 Transgene-Induced Pulmonary Remodeling

2006 • 89 citations

Elevated expression of both mRNA and protein levels of IL-17A in sputum of stable Cystic Fibrosis patients

2010 • 86 citations

Interleukin-13 and Its Receptors in Idiopathic Interstitial Pneumonia: Clinical Implications for Lung Function

2009 • 86 citations

IL-13 Is Pivotal in the Fibro-Obliterative Process of Bronchiolitis Obliterans Syndrome

2007 • 84 citations

IL-13 Receptor α2 Selectively Inhibits IL-13-Induced Responses in the Murine Lung

2008 • 81 citations

Raised interleukin-17 is immunolocalised to neutrophils in cystic fibrosis lung disease

2010 • 80 citations

IL‐13 and IL‐1β promote lung fibroblast growth through coordinated up‐regulation of PDGF‐AA and PDGF‐Rα

2004 • 79 citations

Cationic Amino Acid Transporter-2 Regulates Immunity by Modulating Arginase Activity

2008 • 77 citations

Pulmonary complications of tumor necrosis factor-targeted therapy

2009 • 59 citations

Regulation of Helminth-Induced Th2 Responses by Thymic Stromal Lymphopoietin

2009 • 56 citations

The Antifibrogenic Potential of PPARγ Ligands in Pulmonary Fibrosis

2008 • 55 citations

Obligatory Role for Interleukin-13 in Obstructive Lesion Development in Airway Allografts

2006 • 43 citations

ROLE OF ENDOGENOUS AND EXOGENOUS LIGANDS FOR THE PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR α IN THE DEVELOPMENT OF BLEOMYCIN-INDUCED LUNG INJURY

2005 • 38 citations

The pathophysiological function of peroxisome proliferator-activated receptor-γ in lung-related diseases

2005 • 37 citations

Progressive interstitial fibrosis of the lung in sclerodermoid chronic graft-versus-host disease

2002 • 35 citations

Effects of Anti-IL-13 (Novartis QAX576) on Inflammatory Responses Following Nasal Allergen Challenge (NAC).

2009 • 16 citations