The radiotherapeutic injury – a complex ‘wound’

Inflammation. Basic principles and clinical correlates

1989 • 2,424 citations

Principles and Practice of Radiation Oncology

1999 • 1,911 citations

Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth.

1986 • 1,617 citations

[Long-term results].

1983 • 1,298 citations

Endothelial Apoptosis as the Primary Lesion Initiating Intestinal Radiation Damage in Mice

2001 • 1,245 citations

Clinical Radiation Pathology

1968 • 930 citations

Radiation Biology in Cancer Research

1980 • 782 citations

Transforming growth factor beta is an important immunomodulatory protein for human B lymphocytes.

1986 • 777 citations

Principles and Practice of Radiation Oncology

1998 • 581 citations

Effects of transforming growth factor beta on the functions of natural killer cells: depressed cytolytic activity and blunting of interferon responsiveness.

1986 • 579 citations

Wound Healing: Biochemical and Clinical Aspects

1993 • 535 citations

Inflammation: Basic Principles and Clinical Correlates

1993 • 518 citations

[Fractionation in radiotherapy].

1972 • 487 citations

Mitogenic activity of blood components. I. Thrombin and prothrombin.

1975 • 481 citations

Increased tumor necrosis factor alpha mRNA after cellular exposure to ionizing radiation.

1989 • 473 citations

An Experimental Study in the Rat

1986 • 448 citations

Wound Healing: Biochemical & Clinical Aspects

1992 • 447 citations

Treatment volume and tissue tolerance

1988 • 441 citations

Consequential late effects in normal tissues

2001 • 432 citations

Cellular basis of radiation-induced fibrosis

1995 • 371 citations

Regulated Production of Type I Collagen and Inflammatory Cytokines by Peripheral Blood Fibrocytes

1998 • 370 citations

Fractionation in Radiotherapy

1988 • 345 citations

Radiation biology in cancer research

1978 • 340 citations

Repair capacity and kinetics of human skin during fractionated radiotherapy: Erythema, desquamation, and telangiectasia after 3 and 5 year's follow-up

1989 • 334 citations

Prognostic factors for acute and late skin reactions in radiotheraphy patients

1996 • 306 citations

Modeling of normal tissue response to radiation: The critical volume model

1993 • 302 citations

Cell adhesion molecules mediate radiation-induced leukocyte adhesion to the vascular endothelium.

1996 • 296 citations

Advances in Radiation Biology

1975 • 283 citations

Wound healing following radiation therapy: a review

1997 • 273 citations

Expression of CCR2 by Endothelial Cells

1999 • 272 citations

Accelerated Fractionation in the Radiation Treatment of Head and Neck Cancer—A Critical Comparison of Different Strategies

1988 • 261 citations

Radiation injury in surgical pathology

1978 • 258 citations

Striking Regression of Chronic Radiotherapy Damage in a Clinical Trial of Combined Pentoxifylline and Tocopherol

1999 • 247 citations

Pathogenesis of radiation-induced myocardial fibrosis.

1973 • 234 citations

Oxidation of a specific methionine in thrombomodulin by activated neutrophil products blocks cofactor activity. A potential rapid mechanism for modulation of coagulation.

1992 • 230 citations

Transforming growth factor-beta 1 mediates mast cell chemotaxis.

1994 • 223 citations

Chemotactic response of monocytes to thrombin.

1983 • 221 citations

Patient-to-Patient Variability in the Expression of Radiation-Induced Normal Tissue Injury.

1994 • 220 citations

Molecular biology mechanisms in the radiation induction of pulmonary injury syndromes: Interrelationship between the alveolar macrophage and the septal fibroblast

1992 • 216 citations

LEAD POISONING FROM HOME-MADE WINE

1960 • 213 citations

Radiation-induced transforming growth factor beta and subsequent extracellular matrix reorganization in murine mammary gland.

1993 • 208 citations

Thrombin‐induced chemotaxis and aggregation of neutrophils

1986 • 206 citations

Diabetes mellitus: a predictor for late radiation morbidity

1999 • 198 citations

Effects of irradiation on the release of growth factors from cultured bovine, porcine, and human endothelial cells.

1989 • 197 citations

Radiation-induced hypoxia may perpetuate late normal tissue injury

2001 • 195 citations

Patient-to-patient variability in the expression of radiation-induced normal tissue injury

1994 • 192 citations

Autocrine effects of fibroblast growth factor in repair of radiation damage in endothelial cells.

1991 • 186 citations

Relationship between early and late normal-tissue injury after postmastectomy radiotherapy

1991 • 184 citations

The nature of latent cerebral irradiation damage and its modification by hypertension

1970 • 179 citations

Wound complications in the multimodality treatment of extremity and superficial truncal sarcomas.

1987 • 173 citations

Radiation-Induced Vascular Injury and Its Relation to Late Effects in Normal Tissues

1981 • 170 citations

Temporal modulation of TGF-beta 1 and beta-actin gene expression in pig skin and muscular fibrosis after ionizing radiation.

1993 • 165 citations

Radiosensitivity of capillary endothelium

1973 • 164 citations

Biology Of Chronic Radiation Effect On Tissues And Wound Healing

1993 • 164 citations

Successful treatment of radiation-induced fibrosis using and Mn-SOD: An experimental study

1996 • 157 citations

Acute and late reactions to radiation therapy in patients with collagen vascular diseases

1993 • 157 citations

Radiotherapy treatment planning and long-term follow-up with [11C]methionine PET in patients with low-grade astrocytoma

2000 • 153 citations

Deficiency of Microvascular Thrombomodulin and Up-Regulation of Protease-Activated Receptor-1 in Irradiated Rat Intestine

2002 • 152 citations

Thrombin induces endothelial type II activation in vitro: IL-1 and TNF-alpha-independent IL-8 secretion and E-selectin expression.

1997 • 152 citations

Do acute mucosal reactions lead to consequential late reactions in patients with head and neck cancer?

1999 • 150 citations

Regulation of tumor necrosis factor gene expression by ionizing radiation in human myeloid leukemia cells and peripheral blood monocytes.

1991 • 148 citations

Acute radiation proctitis: a sequential clinicopathologic study during pelvic radiotherapy

2000 • 143 citations

Aortic Arteriosclerosis in the Dog After Localized Aortic X-lrradiation

1962 • 142 citations

Radiobiological mechanisms of anti-inflammatory radiotherapy

1999 • 141 citations

Fibrosis, a common pathway to organ failure: angiotensin II and tissue repair.

1997 • 141 citations

9 Thrombin and Prothrombin

1971 • 137 citations

Risks of Head and Neck Surgery in Previously Irradiated Patients

1973 • 131 citations

Preferential Impairment of Nitric Oxide–Mediated Endothelium-Dependent Relaxation in Human Cervical Arteries After Irradiation

1999 • 129 citations

Temporal Modulation of TGF-β1 and β-Actin Gene Expression in Pig Skin and Muscular Fibrosis after Ionizing Radiation

1993 • 128 citations

E-Selectin Gene Induction by Ionizing Radiation Is Independent of Cytokine Induction

1995 • 128 citations

Capillary Injury Preceding Radiation-Induced Myocardial Fibrosis

1971 • 128 citations

Therapeutic approaches to organ fibrosis

1997 • 127 citations

Quantification of late complications after radiation therapy

2001 • 124 citations

Radiation-induced changes in cellularity and proliferation in human oral mucosa

2002 • 124 citations

Wound Complications of Adjuvant Radiation Therapy in Patients with Soft-Tissue Sarcomas

1989 • 123 citations

The synergism of x-irradiation and cholesterol-fat feeding on the development of coronary artery lesions

1964 • 118 citations

Role of leukocyte-endothelial cell adhesion in radiation-induced microvascular dysfunction in rats

1995 • 117 citations

Three A's of repopulation during fractionated irradiation of squamous epithelia: Asymmetry loss, Acceleration of stem-cell divisions and Abortive divisions

1997 • 114 citations

Collagen synthesis by human intestinal smooth muscle cells in culture

1987 • 113 citations

Transforming growth factor β1 selectively augments collagen synthesis by human intestinal smooth muscle cells

1990 • 111 citations

Captopril reduces collagen and mast cell accumulation in irradiated rat lung

1990 • 110 citations

Recombinant soluble transforming growth factor β type II receptor ameliorates radiation enteropathy in mice

2000 • 108 citations

Vascular irradiation damage: its cellular basis and likely consequences.

1986 • 104 citations

Slowed Growth of Cultured Fibroblasts from Human Radiation Wounds

1988 • 100 citations

Protection of transforming growth factor β activity by heparin and fucoidan

1994 • 100 citations

Volume effects in radiobiology as applied to radiotherapy

2000 • 100 citations

Ionizing Radiation Induces Human Intercellular Adhesion Molecule-1 In Vitro

1994 • 99 citations

Radiation-induced pulmonary endothelial dysfunction in rats: Modification by an inhibitor of angiotensin converting enzyme

1988 • 95 citations

Cellular Sources of Transforming Growth Factor-β Isoforms in Early and Chronic Radiation Enteropathy

1998 • 95 citations

A pathway to pulmonary fibrosis: an ultrastructural study of mouse and rat following radiation to the whole body and hemithorax.

1970 • 93 citations

Normal tissue radiobiology: from the laboratory to the clinic

2001 • 92 citations

Granulocyte proteases and hydrogen peroxide synergistically inactivate thrombomodulin of endothelial cells in vitro.

1994 • 88 citations

Is the loss of endothelial thrombomodulin involved in the mechanism of chronicity in late radiation enteropathy?

1997 • 88 citations

Termination of Acute-Phase Response

1998 • 80 citations

Histological Changes in the Larger Blood Vessels of the Hind Limb of the Mouse after X-irradiation

1965 • 80 citations

The Ultrastructure and Etiology of Chronic Radiotherapy Damage in Human Skin

1982 • 79 citations

Assay of Radiation Effects in Mouse Skin as Expressed in Wound Healing

1988 • 78 citations

Thrombin Stimulates Smooth Muscle Cell Procollagen Synthesis and mRNA Levels via a PAR-1 Mediated Mechanism

1998 • 77 citations

Proliferation Equivalent of ‘Accelerated Repopulation’ in Mouse Oral Mucosa

1994 • 76 citations

ARTERIAL HYPERTENSION AND IRRADIATION DAMAGE TO THE NERVOUS SYSTEM

1962 • 76 citations

The radiobiology of intravascular irradiation

1996 • 74 citations

Effects of accelerated fractionation on radiation injury of the small intestine: A new rat model

1988 • 73 citations

Increased transforming growth factor β (TGF-β) immunoreactivity is independently associated with chronic injury in both consequential and primary radiation enteropathy

1997 • 71 citations

Abnormal phenotype of cultured fibroblasts in human skin with chronic radiotherapy damage

1998 • 71 citations

The Effect of Radiation on Connective Tissue

1984 • 70 citations

Prostacyclin synthesis in irradiated endothelial cells cultured from bovine aorta

1985 • 69 citations

Response of swine skin microvasculature to acute single exposures of X rays: quantification of endothelial changes.

1984 • 68 citations

Influence of Short-Term Octreotide Administration on Chronic Tissue Injury, Transforming Growth Factor beta (TGF-beta) Overexpression, and Collagen Accumulation in Irradiated Rat Intestine.

2001 • 66 citations

Morphology of irradiated microvasculature: a combined in vivo and electron-microscopic study.

1982 • 66 citations

The induction of gene expression in mammalian cells by radiation.

1993 • 65 citations

Role of Mast Cells in Early and Delayed Radiation Injury in Rat Intestine

2000 • 65 citations

Vascular Permeability and Late Radiation Fibrosis in Mouse Lung

1985 • 65 citations

Pathogenesis of foam cell lesions in irradiated arteries.

1967 • 64 citations

Mucosal regeneration during radiotherapy

1996 • 63 citations

Ionizing irradiation increases transcription of the von Willebrand factor gene in endothelial cells

1996 • 63 citations

SENSITISATION OF BLOOD-VESSELS TO HYPERTENSIVE DAMAGE BY X-IRRADIATION

1961 • 63 citations

Effects of irradiation on endothelial cell-polymorphonuclear leukocyte interactions

1986 • 63 citations

The synthetic somatostatin analogue, octreotide, ameliorates acute and delayed intestinal radiation injury

1999 • 63 citations

Thrombomodulin as a Marker of Radiation-Induced Endothelial Cell Injury

1992 • 62 citations

Response of Swine Skin Microvasculature to Acute Single Exposures of X Rays: Quantification of Endothelial Changes

1984 • 60 citations

Organizational response of normal tissues to irradiation

2001 • 59 citations

Vascular smooth muscle cell migration mediated by thrombin and urokinase receptor

1995 • 59 citations

Morphological and isoenzymatic differentiation of B-chronic lymphocytic leukaemia cells induced by phorbolester

1986 • 58 citations

Do inflammatory processes contribute to radiation induced erythema observed in the skin of humans?

1998 • 56 citations

Contributions to the Study of Immediate and Early X-ray Reactions with Regard to Chemoprotection

1963 • 53 citations

Effects of Radiation on the Microvasculature

2015 • 52 citations

Interrelationship between the Early Inflammatory Response and Subsequent Fibrosis after Radiation Exposure

1977 • 51 citations

Radiosensitivity in vitro of human fibroblasts derived from patients with a severe skin reaction to radiation therapy

1980 • 50 citations

Significance of overall treatment time for the development of radiation-induced intestinal complications. An experimental study in the rat

1994 • 49 citations

Differential Radiation Response Amongst Proliferating Epithelial Cells

1978 • 46 citations

The Effects of Radiation on Neovascularization in a Rat Model

1996 • 46 citations

Initial events in radiation-induced atheromatosis. II. Damage to intimal cells.

1978 • 45 citations

Modification of collagen and noncollagenous proteins in radiation-induced muscular fibrosis

1988 • 45 citations

Sialyl Lewis X Mimetics Attenuate E-Selectin-Mediated Adhesion of Leukocytes to Irradiated Human Endothelial Cells

1997 • 45 citations

Changes in ling morphology and cell number in radiation pneumonitis and fibrosis: A quantitative ultrastructural study

1987 • 45 citations

Characterization and applications of the disc angiogenesis system

1992 • 43 citations

Irradiation twenty-four hours preoperatively

1969 • 43 citations

The Vascular System

1990 • 42 citations

Acute Radiation Effects on the Content and Release of Plasminogen Activator Activity in Cultured Aortic Endothelial Cells

1985 • 42 citations

Effect of Fibroblast Implants on Wound Healing of Irradiated Skin: Assay of Wound Strength and Quantitative Immunohistology of Collagen

1991 • 41 citations

Transcriptional Regulation of Intercellular Adhesion Molecule-1: PMA-Induction Is Mediated by NFκB

1995 • 41 citations

Thrombin stimulates production of transforming growth factor-beta by cultured human mesangial cells

1997 • 40 citations

Modulation of Vascular Endothelial Permeability by Thrombin

1992 • 40 citations

The Radiation Biology of the Vascular Endothelium

2001 • 40 citations

Radiation-Induced Alteration of Rat Mesangial Cell Transforming Growth Factor-β and Expression of the Genes Associated with the Extracellular Matrix

1996 • 40 citations

The Treatment of Lower Extremity Sarcomas with Wide Excision, Radiotherapy, and Free-Flap Reconstruction

1992 • 39 citations

Inflammatory sequences in acute pulmonary radiation injury.

1976 • 39 citations

Thrombin Stimulates Fibroblast-Mediated Collagen Lattice Contraction by Its Proteolytically Activated Receptor

1994 • 39 citations

Influence of dose-rate on inflammatory damage and adhesion molecule expression after abdominal radiation in the rat

1999 • 37 citations

Influence of Pancreatic Secretion on Late Radiation Enteropathy in the Rat

1985 • 37 citations

Radiation Hypertension and Nephrosclerosis

1970 • 35 citations

Effect of Thrombin Inhibition With Desulfatohirudin on Early Kinetics of Cellular Proliferation After Balloon Angioplasty in Atherosclerotic Rabbits

1996 • 34 citations

High and low dose rate irradiation have opposing effects on cytokine gene expression in human glioblastoma cell lines

1997 • 34 citations

Treatment-time-dependence models of early and delayed radiation injury in rat small intestine

2000 • 33 citations

Changes in transforming growth factor-beta (TGF-beta1), procollagen types I and III mRNA in the rat heart after irradiation

1999 • 33 citations

The time factor and repopulation in tumors and normal tissues

1993 • 32 citations

Effects of X irradiation on angiogenesis.

1990 • 32 citations

Correlation of the dermal microvasculature morphology with the epidermal and the endothelial population changes produced by single X ray fractions of 1649, 2231 and 2619 rad in swine

1985 • 32 citations

The Treatment of Lower Extremity Sarcomas with Wide Excision, Radiotherapy, and Free-Flap Reconstruction

1992 • 32 citations

Abnormal Proliferation and Aging of Cultured Fibroblasts From Pigs With Subcutaneous Fibrosis Induced by Gamma Irradiation

1989 • 31 citations

The Mechanisms of Acceleration of Repopulation in Squamous Epithelia During Daily Irradiation

1999 • 31 citations

Major interactions between radiation therapy and systemic sclerosis: Is there an optimal treatment?

1996 • 30 citations

Effects of X Irradiation on Angiogenesis

1990 • 29 citations

Connexin 43 Expression in Normal and Irradiated Mouse Skin

1997 • 28 citations

Influence of Fraction Size on the Development of Late Radiation Enteropathy: An experimental study in the rat

1996 • 26 citations

Intestinal Complications Following Accelerated Fractionated X-Irradiation: An Experimental Study in the Rat

1990 • 26 citations

Generation of lipid neutrophil chemoattractant by irradiated bovine aortic endothelial cells.

1988 • 25 citations

Fibroblast Implantation Enhances Wound Healing as Indicated by Breaking Strength Determinations

1978 • 24 citations

Early postoperative brachytherapy following free flap reconstruction

1993 • 23 citations

Accumulation of Glycosaminoglycans in Radiation-induced Muscular Fibrosis

1992 • 21 citations

Irradiation Effects on Wound Contraction Using a Connective Tissue Model

1993 • 20 citations

Safety of ¹²⁵iodine and ¹⁹²iridium implants to the canine carotid artery: Preliminary report

1985 • 19 citations

INITIAL EVENTS IN RADIATION-INDUCED ATHEROMATOSIS

1976 • 18 citations

Preoperative irradiation for unresectable carcinoma of the rectum.

1993 • 17 citations

Vascular damage after acute local irradiation: a light and electron microscope study.

1986 • 16 citations

Effects of X-radiation on Growth and Function of the Repair Blastema (Granulation Tissue)

1974 • 15 citations

Extinction of the weakest

2001 • 14 citations

RADIATION EFFECTS ON MAST CELLS: SECRETORY ABILITY, HISTAMINE RELEASE AND RECOVERY, AND CELL NUMBER

1984 • 13 citations

INFLUENCE OF FRACTION SIZE ON THE DEVELOPMENT OF LATE RADIATION ENTEROPATHY

1996 • 13 citations

Timing of concomitant boost irradiation affects incidence and severity of intestinal complications

1996 • 12 citations

Initial events in radiation-induced atheromatosis. Pt. 1

1975 • 10 citations

Effects of ionizing irradiation on endothelial cell transglutaminase

1993 • 10 citations

Safety of 125iodine and 192iridium implants to the canine carotid artery. Long-term results.

1987 • 9 citations

Effect of low dose radiation on adhesion and apoptosis-discontinuous cytokine expression as one possible mechanism of action

2000 • 8 citations

Advances in Radiation Therapy

1998 • 7 citations

Degranulation of mast cells correlates to radiation-induced increase of vascular permeability

2000 • 6 citations

[Arterial radiation injuries].

1977 • 5 citations

X-irradiated vascular endothelium activates circulating blood components through exocytosis of membranous organelles containing preformed proteins

1998 • 3 citations

A phase III hoosier oncology group study of thoracic radiotherapy (TRT) plus cisplatin (P) and vinblastin (V) with or without hydroxgurea (HX) for locally unresectable non small cell lung cancer (NSCLC)

1998 • 2 citations

49 Irradiation in the setting of collagen vascular disease: Acute and late toxicity

1996 • 2 citations

Effect of low dose radiation on adhesion and apoptosis-results of an ex-vivo model

1998 • 1 citations