Glycation of collagen: the basis of its central role in the late complications of ageing and diabetes

The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus

1993 • 23,535 citations

Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes

1991 • 6,550 citations

Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study

1993 • 4,414 citations

Role of Oxidative Stress in Development of Complications in Diabetes

1991 • 3,774 citations

Advanced glycosylation products quench nitric oxide and mediate defective endothelium-dependent vasodilatation in experimental diabetes.

1991 • 1,161 citations

Aminoguanidine Prevents Diabetes-Induced Arterial Wall Protein Cross-Linking

1986 • 1,154 citations

Structure Elucidation of a Senescence Cross-Link from Human Extracellular Matrix

1989 • 1,056 citations

Identification of N epsilon-carboxymethyllysine as a degradation product of fructoselysine in glycated protein.

1986 • 830 citations

Isolation and characterization of two binding proteins for advanced glycosylation end products from bovine lung which are present on the endothelial cell surface.

1992 • 808 citations

Role of oxidative stress in development of complications in diabetes

1991 • 787 citations

Accumulation of Maillard reaction products in skin collagen in diabetes and aging.

1993 • 764 citations

Advanced Maillard reaction end products are associated with Alzheimer disease pathology.

1994 • 712 citations

Relation between Complications of Type I Diabetes Mellitus and Collagen-Linked Fluorescence

1986 • 579 citations

Mechanism of Protein Modification by Glyoxal and Glycolaldehyde, Reactive Intermediates of the Maillard Reaction

1995 • 560 citations

Formation of pentosidine during nonenzymatic browning of proteins by glucose. Identification of glucose and other carbohydrates as possible precursors of pentosidine in vivo

1991 • 534 citations

N.epsilon.-(Carboxymethyl)lysine Is a Dominant Advanced Glycation End Product (AGE) Antigen in Tissue Proteins

1995 • 518 citations

Immunochemical detection of advanced glycosylation end products in vivo.

1992 • 496 citations

Glycation, Glycoxidation, and Cross-Linking of Collagen by Glucose: Kinetics, Mechanisms, and Inhibition of Late Stages of the Maillard Reaction

1994 • 453 citations

Mechanism of formation of the Maillard protein cross-link pentosidine. Glucose, fructose, and ascorbate as pentosidine precursors

1991 • 451 citations

The maillard reaction in aging, diabetes and nutrition

1990 • 376 citations

Aging of proteins: isolation and identification of a fluorescent chromophore from the reaction of polypeptides with glucose.

1984 • 372 citations

Structure of hemoglobin AIc: Nature of the N-terminal β chain blocking group

1968 • 350 citations

High-affinity-receptor-mediated uptake and degradation of glucose-modified proteins: a potential mechanism for the removal of senescent macromolecules.

1985 • 312 citations

Aging of Proteins: Immunological Detection of a Glucose-derived Pyrrole Formed during Maillard Reaction in vivo

1989 • 302 citations

Age-dependent accumulation of N.epsilon.-(carboxymethyl)lysine and N.epsilon.-(carboxymethyl)hydroxylysine in human skin collagen

1991 • 298 citations

Pentosidine Formation in Skin Correlates With Severity of Complications in Individuals With Long-Standing IDDM

1992 • 286 citations

The Kinetics of the Thermal Denaturation of Collagen in Unrestrained Rat Tail Tendon Determined by Differential Scanning Calorimetry

1995 • 248 citations

The role of glycation cross-links in diabetic vascular stiffening

1996 • 245 citations

Glucose and Aging

1987 • 244 citations

Oxidation of glycated proteins: age-dependent accumulation of N.epsilon.-(carboxymethyl)lysine in lens proteins

1989 • 239 citations

Immunohistochemical detection of advanced glycosylation end products in diabetic tissues using monoclonal antibody to pyrraline.

1992 • 218 citations

Non‐enzymatic glycosylation of the dipeptide <scp>l</scp>‐carnosine, a potential anti‐protein‐cross‐linking agent

1995 • 207 citations

Maillard Reactions in Chemistry, Food and Health

1994 • 197 citations

Altered cellular interactions between endothelial cells and nonenzymatically glucosylated laminin/type IV collagen.

1992 • 190 citations

Age-related changes in collagen: The identification of reducible lysine-carbohydrate condensation products

1972 • 182 citations

The Amadori product on protein: structure and reactions.

1989 • 171 citations

Evidence for glucose-mediated covalent cross-linking of collagen after glycosylation in vitro

1985 • 164 citations

Thermal stability, mechanical properties and reducible cross-links of rat tail tendon in experimental diabetes

1981 • 151 citations

Role of Oxygen in Cross-Linking and Chemical Modification of Collagen by Glucose

1992 • 150 citations

The effect of nonenzymatic glucosylation on the binding of the main noncollagenous NC1 domain to type IV collagen.

1988 • 147 citations

Studies of the molecular pathogenesis of hexane neuropathy

1982 • 142 citations

Immunological Evidence for the Presence of Advanced Glycosylation End Products in Atherosclerotic Lesions of Euglycemic Rabbits

1995 • 135 citations

Isolation, Purification and Partial Characterization of Novel Fluorophores from aging Human Insoluble Collagen-Rich Tissue

1989 • 129 citations

Detection of d-glucose-derived pyrrole compounds during maillard reaction under physiological conditions

1987 • 126 citations

Glycation, glycoxidation, and cross-linking of collagen by glucose. Kinetics, mechanisms, and inhibition of late stages of the Maillard reaction

1994 • 119 citations

The chemistry of the Maillard reaction under physiological conditions: a review.

1989 • 116 citations

Aminoguanidine: A drug proposed for prophylaxis in diabetes inhibits catalase and generates hydrogen peroxide in vitro

1993 • 116 citations

Detection of 3-deoxyfructose and 3-deoxyglucosone in human urine and plasma: Evidence for intermediate stages of the maillard reaction in vivo

1992 • 115 citations

Mechanism of formation of the putative advanced glycosylation end product and protein cross-link 2-(2-furoyl)-4(5)-(2-furanyl)-1H-imidazole.

1988 • 109 citations

Interactions of elastin and aorta with sugars in vitro and their effects on biochemical and physical properties

1996 • 108 citations

Detection of an advanced glycosylation product bound to protein in situ.

1985 • 106 citations

Quantitative analysis of collagen and elastin cross-links using a single-column system

1992 • 103 citations

Chemistry of collagen cross-links: glucose-mediated covalent cross-linking of type-IV collagen in lens capsules

1993 • 101 citations

Non-enzymic glycation of fibrous collagen: reaction products of glucose and ribose

1995 • 98 citations

Effects of age and diabetes mellitus on the solubility of collagen from human skin, tracheal cartilage and dura mater

1982 • 97 citations

Formation of Reactive Intermediates from Amadori Compounds under Physiological Conditions

1995 • 96 citations

Catalysis of lipid peroxidation by glucose and glycosylated collagen

1988 • 95 citations

Chemical cross-linking restrictions on models for the molecular organization of the collagen fibre

1980 • 94 citations

Isolation and partial characterization of collagen chains dimerized by sugar-derived cross-links.

1988 • 91 citations

Relationship between the content of lysyl oxidase-dependent cross-links in skin collagen, nonenzymatic glycosylation, and long-term complications in type I diabetes mellitus.

1990 • 88 citations

Pentosidine formation in skin correlates with severity of complications in individuals with long-standing IDDM

1992 • 88 citations

The role of nonenzymatic glycosylation, transition metals, and free radicals in the formation of collagen aggregates

1991 • 86 citations

Chromatographic evidence for pyrraline formation during protein glycation in vitro and in vivo

1995 • 86 citations

Non-enzymic glycosylation (glycation) of lens proteins by galactose and protection by aspirin and reduced glutathione

1988 • 86 citations

Sites of glycation of human and horse liver alcohol dehydrogenase in vivo.

1991 • 76 citations

Inhibition of lens crystallin glycation and high molecular weight aggregate formation by aspirin in vitro and in vivo.

1989 • 75 citations

Peroxidation Potential and Antioxidant Activity of Serum in Patients with Diabetes Mellitus and Myocard Infarction

1995 • 64 citations

Platelet aggregation by basement membrane - associated collagens

1980 • 63 citations

The effects of aminoguanidine on the glycation (non-enzymic glycosylation) of lens proteins

1990 • 63 citations

Presence of 3-Deoxyglucosone, a Potent Protein Crosslinking Intermediate of Maillard Reaction, in Diabetic Serum

1993 • 62 citations

Maillard reactions in chemistry, food and health

1995 • 58 citations

Polylysines modified with malonaldehyde, hydroperoxylinoleic acid and monofunctional aldehydes.

1985 • 44 citations

Aspirin prevents the nonenzymatic glycosylation and carbamylation of the human eye lens crystallins in vitro

1988 • 43 citations

Site specificity of glycation of horse liver alcohol dehydrogenase in vitro

1993 • 41 citations

Determination of protein-bound 2-amino-6-(2-formyl-1-pyrrolyl)-hexanoic acid (?pyrraline?) by ion exchange Chromatography and photodiode array detection

1993 • 37 citations

Mechanisms of in vitro pyrrole adduct autoxidation in 2,5-hexanedione-treated protein.

1986 • 31 citations

Effects of in vitro N-glucosylation on type-I collagen fibrillogenesis

1981 • 30 citations

Evidence against in vivo presence of 2-(2-furoyl)-4(5)-(2-furanyl)-1H-imidazole, a major fluorescent advanced end product generated by nonenzymatic glycosylation.

1988 • 29 citations

Nε-carboxymethyllysine formation by direct addition of glyoxal to lysine during the Maillard reaction

1995 • 28 citations

Distribution of non‐enzymatically bound glucose in in vivo and in vitro glycosylated type I collagen molecules

1984 • 25 citations

Non-specific binding of advanced-glycosylation end-products to macrophages outweighs specific receptor-mediated interactions

1994 • 25 citations

Absence of Brown Product FFI in Nondiabetic and Diabetic Rat Collagen

1990 • 22 citations

Evidence against the formation of 2-amino-6-(2-formyl-5-hydroxymethyl-pyrrol-l-yl)-hexanoic acid ('pyrraline') as an early-stage product or advanced glycation end product in non-enzymic protein glycation

1993 • 22 citations

The reaction of malondialdehyde with lens proteins and the protective effect of aspirin

1993 • 21 citations

Immunoelectron microscopic analyses of Maillard reaction products in bovine anterior lens capsule and Descemet's membrane

1994 • 20 citations

The in Vivo Glycation of Diabetic Tendon Collagen Studied by Neutron Diffraction

1993 • 19 citations

X-Ray Structures of a 3-Amino-5- and a 3-Amino-6-Substituted Triazine, Produced as a Result of a Reaction of 3-Deoxy-D-Erythro-Hexos-2-Ulose (3-Deoxyglucosone) with Aminoguanidine

1992 • 19 citations

On the Formation of 2-Acylpyrroles and 3-Pyridinols in the Maillard Reaction through Strecker Degradation.

1983 • 18 citations

Identification of furoyl-containing advanced glycation products in collagen samples from diabetic and healthy rats

1990 • 18 citations

High-affinity-receptor-mediated uptake and degradation of glucose-modified proteins: A potential mechanism for the removal of senescent macromolecules

1985 • 18 citations

Evidence of acid hydrolysis as responsible for 2-(2-furoyl)-4(5)-(2-furanyl)-1H-imidazole (FFI) production

1990 • 16 citations

Interaction of malondialdehyde-modified bovine serum albumin and mouse peritoneal macrophages.

1988 • 15 citations

Oxidative Damage of Glycated Protein in the Presence of Transition Metal Ion.

1991 • 13 citations

Absence of brown product FFI in nondiabetic and diabetic rat collagen

1990 • 9 citations

The effects of aminoguanidine on the glycation (non-enzymatic glycosylation) of lens proteins

1990 • 4 citations