Characterization of the interleukin 4 receptor. Structure and signal transduction pathways

Mast cell lines produce lymphokines in response to cross-linkage of FcεRI or to calcium ionophores

1989 • 1,199 citations

Identification of a T cell-derived b cell growth factor distinct from interleukin 2.

1982 • 1,095 citations

Phosphatidylinositol 3′-kinase is activated by association with IRS-1 during insulin stimulation.

1992 • 1,030 citations

The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice.

1992 • 1,029 citations

Interleukin-4: a prototypic immunoregulatory lymphokine

1991 • 878 citations

IL-4 induces adherence of human eosinophils and basophils but not neutrophils to endothelium. Association with expression of VCAM-1.

1992 • 838 citations

B cell stimulatory factor-1 enhances the IgE response of lipopolysaccharide-activated B cells.

1986 • 797 citations

Differential regulation of T helper phenotype development by interleukins 4 and 10 in an alpha beta T-cell-receptor transgenic system.

1992 • 762 citations

Insulin rapidly stimulates tyrosine phosphorylation of a Mr-185,000 protein in intact cells

1985 • 665 citations

The murine interleukin-4 receptor: Molecular cloning and characterization of secreted and membrane bound forms

1989 • 645 citations

A novel family of growth factor receptors: A common binding domain in the growth hormone, prolactin, erythropoietin and IL-6 receptors, and the p75 IL-2 receptor β-chain

1989 • 551 citations

Isolation and characterization of a mouse interleukin cDNA clone that expresses B-cell stimulatory factor 1 activities and T-cell- and mast-cell-stimulating activities.

1986 • 529 citations

Cloning of cDNA encoding the murine IgG1 induction factor by a novel strategy using SP6 promoter

1986 • 480 citations

Increased expression of Ia antigens on resting B cells: an additional role for B-cell growth factor.

1984 • 438 citations

Human interleukin 4 receptor confers biological responsiveness and defines a novel receptor superfamily.

1990 • 430 citations

Serological, biochemical, and functional identity of B cell-stimulatory factor 1 and B cell differentiation factor for IgG1.

1985 • 410 citations

IRS-1: Essential for Insulin- and IL-4-Stimulated Mitogenesis in Hematopoietic Cells

1993 • 401 citations

Involvement of ras p21 protein in signal-transduction pathways from interleukin 2, interleukin 3, and granulocyte/macrophage colony-stimulating factor, but not from interleukin 4.

1991 • 351 citations

Signal transduction of the human granulocyte-macrophage colony- stimulating factor and interleukin-3 receptors involves tyrosine phosphorylation of a common set of cytoplasmic proteins

1990 • 294 citations

Receptors for B-cell stimulatory factor-1 expressed on cells of haematopoietic lineage

1987 • 280 citations

Mouse splenic and bone marrow cell populations that express high-affinity Fc epsilon receptors and produce interleukin 4 are highly enriched in basophils.

1991 • 259 citations

Expression of high affinity receptors for murine interleukin 4 (BSF-1) on hemopoietic and nonhemopoietic cells.

1988 • 244 citations

Characterization of the human B cell stimulatory factor 1 receptor.

1987 • 232 citations

Hematopoietic growth factors activate the tyrosine phosphorylation of distinct sets of proteins in interleukin-3-dependent murine cell lines.

1988 • 222 citations

p21ras activation via hemopoietin receptors and c-kit requires tyrosine kinase activity but not tyrosine phosphorylation of p21ras GTPase-activating protein.

1992 • 213 citations

IL-4 activates a distinct signal transduction cascade from IL-3 in factor-dependent myeloid cells.

1992 • 191 citations

Common elements in interleukin 4 and insulin signaling pathways in factor-dependent hematopoietic cells.

1993 • 173 citations

Interleukin 2 induces tyrosine phosphorylation and activation of p72-74 Raf-1 kinase in a T-cell line.

1991 • 165 citations

Up-regulation of interleukin 4/B-cell stimulatory factor 1 receptor expression.

1988 • 145 citations

Characterization of the high-affinity cell-surface receptor for murine B-cell-stimulating factor 1.

1987 • 140 citations

Multiple Hematopoietic Growth Factors Signal Through Tyrosine Phosphorylation

1990 • 125 citations

Molecular cloning of a cDNA encoding the human interleukin 4 receptor

1990 • 119 citations

Effect of B cell stimulatory factor-1 (interleukin 4) on Fc epsilon and Fc gamma receptor expression on murine B lymphocytes and B cell lines.

1987 • 117 citations

Proliferative action of erythropoietin is associated with rapid protein tyrosine phosphorylation in responsive B6SUt.EP cells.

1991 • 115 citations

Interleukin 4 activates human B lymphocytes via transient inositol lipid hydrolysis and delayed cyclic adenosine monophosphate generation

1990 • 113 citations

Expression cloning of a cDNA encoding the murine interleukin 4 receptor based on ligand binding.

1990 • 108 citations

Interleukin 7 receptor ligation stimulates tyrosine phosphorylation, inositol phospholipid turnover, and clonal proliferation of human B-cell precursors.

1991 • 90 citations

Identification of an essential region for growth signal transduction in the cytoplasmic domain of the human interleukin-4 receptor

1992 • 75 citations

Identification of interleukin 4 receptor‐associated proteins and expression of both high‐ and low‐affinity binding on human lymphoid cells

1989 • 75 citations

BSF-1 action on resting B cells does not require elevation of inositol phospholipid metabolism or increased [Ca2+]i.

1986 • 74 citations

BSF1 induces membrane protein phosphorylation but not phosphoinositide metabolism, Ca2+ mobilization, protein kinase C translocation, or membrane depolarization in resting murine B lymphocytes.

1986 • 70 citations

Internalization of Human Interleukin 4 and Transient Down-regulation of Its Receptor in the CD23-inducible Jijoye Cells

1989 • 62 citations

Purification of a 130-kDa T cell glycoprotein that binds human interleukin 4 with high affinity.

1990 • 42 citations

Differential effects of interleukin-2 and interleukin-4 on protein tyrosine phosphorylation in factor-dependent murine T cells

1990 • 42 citations

Protein kinase C plays an inhibitory role in interleukin 3- and interleukin 4-mediated mast cell proliferation.

1990 • 40 citations

The IL-4 receptor: biochemical characterization of IL-4-binding molecules in a T cell line expressing large numbers of receptors.

1991 • 39 citations

Increased expression of Ia antigens on resting B cells: An additional role for B-cell growth factor

1985 • 30 citations

The Chimeric Receptor between Interleukin-2 Receptor β Chain and Interleukin-4 Receptor Transduces Interleukin-2 Signal

1993 • 20 citations

Comparative analysis of IL-2 and IL-3 induced tyrosine phosphorylation.

1989 • 14 citations

Cross-linking of interleukin 4 to surface molecules on murine T and B lymphocytes.

1989 • 13 citations