Structural elements that regulate pp59c-fyn catalytic activity, transforming potential, and ability to associate with polyomavirus middle-T antigen

Selective extraction of polyoma DNA from infected mouse cell cultures

1967 • 5,357 citations

The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

1988 • 1,442 citations

The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes.

1988 • 716 citations

Activation and suppression of pp60c-src transforming ability by mutation of its primary sites of tyrosine phosphorylation

1987 • 648 citations

Tyrosine phosphorylation regulates the biochemical and biological properties of pp60c-src

1987 • 567 citations

Tyr ⁵²⁷ Is Phosphorylated in pp60 ^{c- src} : Implications for Regulation

1986 • 567 citations

Polyoma virus transforming protein associates with the product of the c-src cellular gene

1983 • 497 citations

Activation of the pp60c-src kinase by middle T antigen binding or by dephosphorylation.

1985 • 439 citations

Cell transformation by pp60c-src mutated in the carboxy-terminal regulatory domain

1987 • 410 citations

Characterization of sites for tyrosine phosphorylation in the transforming protein of Rous sarcoma virus (pp60v-src) and its normal cellular homologue (pp60c-src).

1981 • 363 citations

Identification of multiple novel polypeptide substrates of the v-src, v-yes, v-fps, v-ros, and v-erb-B oncogenic tyrosine protein kinases utilizing antisera against phosphotyrosine.

1988 • 351 citations

Enhancement of cellular src gene product associated tyrosyl kinase activity following polyoma virus infection and transformation

1984 • 333 citations

Purified maturation promoting factor phosphorylates pp60c-src at the sites phosphorylated during fibroblast mitosis

1989 • 319 citations

Dephosphorylation or antibody binding to the carboxy terminus stimulates pp60c-src.

1986 • 257 citations

Neoplastic transformation induced by an activated lymphocyte-specific protein tyrosine kinase (pp56lck).

1988 • 232 citations

yes-related protooncogene, syn, belongs to the protein-tyrosine kinase family.

1986 • 219 citations

Mutation of a site of tyrosine phosphorylation in the lymphocyte-specific tyrosine protein kinase, p56lck, reveals its oncogenic potential in fibroblasts.

1988 • 208 citations

The complex of polyoma virus middle-T antigen and pp60c-src.

1984 • 196 citations

Expression of a novel form of the fyn proto-oncogene in hematopoietic cells.

1989 • 174 citations

Association of the polyomavirus middle-T antigen with c-yes protein

1987 • 172 citations

Monoclonal antibodies to Rous sarcoma virus pp60src react with enzymatically active cellular pp60src of avian and mammalian origin

1984 • 163 citations

Altered sites of tyrosine phosphorylation in pp60c-src associated with polyomavirus middle tumor antigen.

1986 • 147 citations

Identification and characterization of p59fyn (a src-like protein tyrosine kinase) in normal and polyoma virus transformed cells.

1988 • 145 citations

Isolation and Oncogenic Potential of a Novel Human src-Like Gene

1986 • 113 citations

Peptide antibodies to the human c-fyn gene product demonstrate pp59c-fyn is capable of complex formation with the middle-T antigen of polyomavirus.

1988 • 113 citations

Specialized protein tyrosine kinase proto-oncogenes in hematopoietic cells

1989 • 99 citations

Acquisition of transforming properties by FYN, a normal SRC-related human gene.

1988 • 87 citations

Activation of pp60c-src transforming potential by mutations altering the structure of an amino terminal domain containing residues 90-95.

1988 • 85 citations

Dephosphorylation or Antibody Binding to the Carboxy Terminus Stimulates pp60^c-src

1986 • 80 citations

Association of p60fyn with middle tumor antigen in murine polyomavirus-transformed rat cells

1989 • 72 citations

Overexpression of src family gene for tyrosine-kinase p59fyn in CD4-CD8- T cells of mice with a lymphoproliferative disorder.

1989 • 68 citations

Neoplastic Transformation Induced by an Activated Lymphocyte-Specific Protein Tyrosine Kinase (pp56^lck)

1988 • 66 citations

The carboxy terminus of pp60c-src is a regulatory domain and is involved in complex formation with the middle-T antigen of polyomavirus.

1988 • 50 citations

Altered Sites of Tyrosine Phosphorylation in pp60^c-src Associated with Polyomavirus Middle Tumor Antigen

1986 • 48 citations

Transformation of NIH 3T3 fibroblasts by an activated form of p59hck.

1989 • 42 citations

p56lck protein-tyrosine kinase is cytoskeletal and does not bind to polyomavirus middle T antigen

1988 • 42 citations

Mutations around the NG59 lesion indicate an active association of polyoma virus middle-T antigen with pp60c-src is required for cell transformation.

1986 • 42 citations

Identification of fyn-encoded proteins in normal human blood cells.

1989 • 31 citations

pp60^c-src Variants Containing Lesions That Affect Phosphorylation at Tyrosines 416 and 527

1989 • 29 citations

Tyrosine phosphorylation of a c-Src-like protein is increased in membranes of CD4- CD8- T lymphocytes from lpr/lpr mice.

1989 • 28 citations

The Carboxy Terminus of pp60^c-src is a Regulatory Domain and is Involved in Complex Formation with the Middle-T Antigen of Polyomavirus

1988 • 19 citations

The amino-terminal region of pp60c-src has a modulatory role and contains multiple sites of tyrosine phosphorylation.

1990 • 15 citations

Tyrosine Phosphorylation of a c-Src-Like Protein Is Increased in Membranes of CD4^- CD8^- T Lymphocytes from lpr/lpr Mice

1989 • 6 citations