Peptide growth factors and wound healing

Angiogenic Factors

1987 • 3,702 citations

Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix.

1986 • 2,499 citations

Transforming growth factor-beta in human platelets. Identification of a major storage site, purification, and characterization.

1983 • 1,613 citations

The role of the macrophage in wound repair. A study with hydrocortisone and antimacrophage serum.

1975 • 1,445 citations

Some recent advances in the chemistry and biology of transforming growth factor-beta.

1987 • 1,308 citations

Transforming growth factor type beta induces monocyte chemotaxis and growth factor production.

1987 • 1,287 citations

Macrophage-induced angiogenesis is mediated by tumour necrosis factor-α

1987 • 1,210 citations

Wound Macrophages Express TGF-α and Other Growth Factors in Vivo: Analysis by mRNA Phenotyping

1988 • 1,107 citations

Accelerated Healing of Incisional Wounds in Rats Induced by Transforming Growth Factor-β

1987 • 938 citations

Stimulation of the chemotactic migration of human fibroblasts by transforming growth factor beta.

1987 • 791 citations

Platelet-derived growth factor in chemotactic for fibroblasts.

1982 • 744 citations

Enhancement of Wound Healing by Topical Treatment with Epidermal Growth Factor

1989 • 673 citations

Transforming growth factor beta 1 positively regulates its own expression in normal and transformed cells.

1988 • 604 citations

Platelet-derived growth factor and transforming growth factor-beta enhance tissue repair activities by unique mechanisms.

1989 • 591 citations

Chemotaxis of monocytes and neutrophils to platelet-derived growth factor.

1982 • 553 citations

Growth factors in wound healing. Single and synergistic effects on partial thickness porcine skin wounds.

1989 • 539 citations

Platelet-derived growth factor: mechanism of action and possible in vivo function.

1990 • 491 citations

Role of platelet-derived growth factor in wound healing: synergistic effects with other growth factors.

1987 • 421 citations

Transforming growth factor beta increases mRNA for matrix proteins both in the presence and in the absence of changes in mRNA stability.

1988 • 420 citations

Human plasma epidermal growth factor/beta-urogastrone is associated with blood platelets.

1983 • 414 citations

Immunoreactive fibroblast growth factor in cells of peritoneal exudate suggests its identity with macrophage-derived growth factor

1985 • 372 citations

Epithelial Wound Healing Enhanced by Transforming Growth Factor-α and Vaccinia Growth Factor

1987 • 368 citations

Platelet alpha granules contain a growth factor for fibroblasts

1979 • 355 citations

Healing of experimental intestinal anastomoses

1990 • 344 citations

Transforming growth factor beta stimulates the expression of fibronectin and of both subunits of the human fibronectin receptor by cultured human lung fibroblasts.

1988 • 340 citations

Sustained release of epidermal growth factor accelerates wound repair.

1985 • 309 citations

Transforming growth factor beta reverses the glucocorticoid-induced wound-healing deficit in rats: possible regulation in macrophages by platelet-derived growth factor.

1989 • 308 citations

Recombinant basic fibroblast growth factor stimulates wound healing in healing-impaired db/db mice.

1990 • 307 citations

Enhancement of epidermal regeneration by biosynthetic epidermal growth factor.

1986 • 301 citations

Effect of growth factors on hyaluronan synthesis in cultured human fibroblasts

1989 • 298 citations

Human endothelial cells are chemotactic to endothelial cell growth factor and heparin.

1985 • 282 citations

Acceleration of Tensile Strength of Incisions Treated with EGF and TGF-β

1988 • 279 citations

Stimulation of granulation tissue formation by platelet-derived growth factor in normal and diabetic rats.

1985 • 277 citations

Recombinant basic fibroblast growth factor accelerates wound healing

1988 • 269 citations

Effects of growth factors in vivo. I. Cell ingrowth into porous subcutaneous chambers.

1987 • 239 citations

Stimulation of in vitro human skin collagenase expression by platelet-derived growth factor.

1985 • 236 citations

Syndecan, a developmentally regulated cell surface proteoglycan that binds extracellular matrix and growth factors

1990 • 218 citations

Epidermal and Dermal Effects of Epidermal Growth Factor During Wound Repair

1990 • 197 citations

Role of growth factors in inflammation and repair

1989 • 189 citations

Transforming growth factor-β: multifunctional regulator of differentiation and development

1990 • 181 citations

The Reversal of an Adriamycin® Induced Healing Impairment with Chemoattractants and Growth Factors

1986 • 175 citations

Transforming growth factor β levels in rat wound chambers

1987 • 161 citations

Reversal of impaired wound healing in irradiated rats by platelet-derived growth faetor-BB

1989 • 161 citations

Tumor Necrosis Factor and Wound Healing

1990 • 145 citations

EGF and TGF‐alpha are potent chemoattractants for endothelial cells and EGF‐like peptides are present at sites of tissue regeneration

1989 • 142 citations

Transforming growth factor-beta stimulates wound healing and modulates extracellular matrix gene expression in pig skin. I. Excisional wound model.

1990 • 138 citations

Differential regulation of expression of two platelet-derived growth factor receptor subunits by transforming growth factor-β

1989 • 136 citations

Fibroblasts from wounds of different stages of repair vary in their ability to contract a collagen gel in response to growth factors

1990 • 114 citations

Pretranslational regulation of type I collagen, fibronectin, and a 50-kilodalton noncollagenous extracellular protein by dexamethasone in rat fibroblasts.

1986 • 114 citations

Differential stimulation of collagenase and chemotactic activity in fibroblasts derived from rat wound repair tissue and human skin by growth factors

1989 • 114 citations

Transforming growth factor β1 selectively augments collagen synthesis by human intestinal smooth muscle cells

1990 • 111 citations

Growth factors. Their biology and promise in dermatologic diseases and tissue repair

1989 • 110 citations

Stimulation of Wound Healing by Epidermal Growth Factor

1986 • 106 citations

Growth Factors For Wound Healing

1989 • 101 citations

Collagen synthesis by human fibroblasts. Regulation by transforming growth factor-β in the presence of other inflammatory mediators

1989 • 95 citations

Epidermal growth factor increases collagen production in granulation tissue by stimulation of fibroblast proliferation and not by activation of procollagen genes

1987 • 93 citations

Regulation of collagen metabolism and cell growth by epidermal growth factor and ascorbate in cultured human skin fibroblasts

1988 • 92 citations

Macrophages: Important Physiologic and Pathologic Sources of Polypeptide Growth Factors

1990 • 90 citations

Glucocorticoids decrease the synthesis of type I procollagen mRNAs

1986 • 86 citations

Transforming Growth Factor-β Regulation of Collagenase, 72Kda-Progelatinase, Timp and Pai-1 Expression in Rat Bone Cell Populations and Human Fibroblasts

1989 • 80 citations

Epidermal Growth Factor in Alkali-Burned Corneal Epithelial Wound Healing

1987 • 78 citations

Growth Factors

1989 • 76 citations

Role of collagenase in colonic anastomoses: a reappraisal

1988 • 70 citations

Epidermal growth factor increases granulation tissue formation dose dependently

1987 • 69 citations

The Effect of Epidermal Growth Factor on Epithelial Healing After Penetrating Keratoplasty in Human Eyes

1984 • 69 citations

Exogenous transforming growth factor-beta 2 enhances connective tissue formation and wound strength in guinea pig dermal wounds healing by secondary intent.

1990 • 65 citations

Differential acceleration of healing of surgical incisions in the rabbit gastrointestinal tract by platelet-derived growth factor and transforming growth factor, type beta.

1990 • 59 citations

Factors influencing blood supply in wound granuloma quantitated by a new in vivo technique.

1989 • 58 citations

Reversal of Adriamycin-impaired wound healing by transforming growth factor-beta.

1989 • 56 citations

Epidermal growth factor in blood

1986 • 51 citations

Cortisol decreases the concentration of translatable type-I procollagen mRNA species in the developing chick-embryo calvaria

1981 • 46 citations

Epidermal growth factor increases tensile strength in intestinal wounds in pigs

1990 • 43 citations

Epidermal Growth Factor and Insulin Act Synergistically During Diabetic Healing

1990 • 42 citations

Lack of effect of topically applied epidermal growth factor (EGF) on epidermal growth in man in vivo

1980 • 40 citations

Inositol 1,4,5,6-tetrakisphosphate is phosphorylated in rat liver by a 3-kinase that is distinct from inositol 1,4,5-trisphosphate 3-kinase.

1994 • 37 citations

The Accumulation of Type I Collagen Mrnas in Human Embryonic Lung Fibroblasts Stimulated by Transforming Growth Factor-β

1990 • 35 citations

Gene expression in normal and doxorubicin-impaired wounds: importance of transforming growth factor-beta.

1990 • 33 citations

Epidermal growth factor (EGF) prevents methylprednisolone-induced inhibition of wound healing

1989 • 29 citations

Heterogeneity among human mononuclear phagocytes in their secretion of lysozyme, interleukin 1 and type-β transforming growth factor: a quantitative analysis at the single-cell level

1989 • 27 citations

Prospective: a retrospective perspective on the nature of wounds.

1988 • 17 citations

Recombinant DNA and Surgery

1990 • 10 citations

Nonclinical regulatory considerations for wound‐healing growth factors

1990 • 7 citations

Effects of glucocorticoids on deoxyribonucleic acid(DNA) synthesis stimulated by growth factors in cultured rat skin fibroblasts.

1990 • 3 citations