Peptide‐specific activation of cytolytic CD4⁺ T lymphocytes against tumor cells bearing mutated epitopes of K‐ras p21

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

ras oncogenes in human cancer: a review.

1989 • 5,116 citations

ras GENES

1987 • 3,818 citations

Redesign of Retrovirus Packaging Cell Lines To Avoid Recombination Leading to Helper Virus Production

1986 • 1,276 citations

Sequence analysis of peptides bound to MHC class II molecules

1991 • 1,071 citations

Antigen-inducible, H-2-restricted, interleukin-2-producing T cell hybridomas. Lack of independent antigen and H-2 recognition

1981 • 1,048 citations

Hybridoma cell lines secreting monoclonal antibodies to mouse H-2 and Ia antigens.

1980 • 850 citations

Redesign of retrovirus packaging cell lines to avoid recombination leading to helper virus production.

1986 • 828 citations

Establishment and Characterization of BALB/c Lymphoma Lines with B Cell Properties

1979 • 677 citations

Peptides Presented to the Immune System by the Murine Class II Major Histocompatibility Complex Molecule I-A _d

1992 • 654 citations

Adoptive T Cell Therapy of Tumors: Mechanisms Operative in the Recognition and Elimination of Tumor Cells

1991 • 619 citations

Continuous proliferation of murine antigen-specific helper T lymphocytes in culture.

1979 • 522 citations

Biologic Therapy of Cancer

1992 • 476 citations

IL-4 and IFN (alpha and gamma) exert opposite regulatory effects on the development of cytolytic potential by Th1 or Th2 human T cell clones.

1992 • 430 citations

Localization of the src gene product of the Harvey strain of MSV to plasma membrane of transformed cells by electron microscopic immunocytochemistry

1980 • 404 citations

Fas antigen is the major target molecule for CD4+ T cell-mediated cytotoxicity.

1994 • 386 citations

The Cell Biology of Antigen Processing and Presentation

1991 • 349 citations

Derivation of a T cell line that is highly responsive to IL-4 and IL-2 (CT.4R) and of an IL-2 hyporesponsive mutant of that line (CT.4S).

1989 • 289 citations

Influenza virus-specific CD4+ T helper type 2 T lymphocytes do not promote recovery from experimental virus infection.

1994 • 283 citations

Interferon-gamma induces enhanced expression of Ia and H-2 antigens on B lymphoid, macrophage, and myeloid cell lines.

1983 • 228 citations

Flow cytometry as an analytical and preparative tool in immunology

1982 • 220 citations

Human T lymphocytes recognize a peptide of single point-mutated, oncogenic ras proteins.

1991 • 208 citations

Enhancing the efficiency of DNA-mediated gene transfer in mammalian cells

1981 • 208 citations

DNA fragmentation: manifestation of target cell destruction mediated by cytotoxic T-cell lines, lymphotoxin-secreting helper T-cell clones, and cell-free lymphotoxin-containing supernatant.

1986 • 152 citations

T cell recognition of transforming proteins encoded by mutated ras proto-oncogenes.

1991 • 126 citations

Expression of specific cytolytic activity by H-2I region-restricted, influenza virus-specific T lymphocyte clones.

1985 • 119 citations

Mutational activation of oncogenes in animal model systems of carcinogenesis (MTR 07217)

1987 • 115 citations

The regulation and function of p21ras in T cells

1992 • 98 citations

"Exon-shuffling" maps control of antibody- and T-cell-recognition sites to the NH2-terminal domain of the class II major histocompatibility polypeptide A beta.

1985 • 98 citations

Unexpected expression of a unique mixed-isotype class II MHC molecule by transfected L-cells

1986 • 97 citations

Regulation of carcinoembryonic antigen expression in different human colorectal tumor cells by interferon-gamma.

1990 • 91 citations

CD4+ T cell clones specific for the human p97 melanoma-associated antigen can eradicate pulmonary metastases from a murine tumor expressing the p97 antigen.

1991 • 86 citations

Identification of two cytotoxic T lymphocyte-recognized epitopes in the Ras protein.

1993 • 83 citations

Lysis of ras oncogene-transformed cells by specific cytotoxic T lymphocytes elicited by primary in vitro immunization with mutated ras peptide.

1994 • 82 citations

A novel HLA class II molecule (DRα–sDQβ) created by mismatched isotype pairing

1987 • 78 citations

Ras p21: effects and regulation

1991 • 78 citations

Characterization of tumor-infiltrating CD4+ T cells as Th1 cells based on lymphokine secretion and functional properties.

1990 • 70 citations

Cytotoxic T-Cell Response and In Vivo Protection Against Tumor Cells Harboring Activated ras Proto-oncogenes

1993 • 66 citations

T-cell responses against products of oncogenes: Generation and characterization of human T-cell clones specific for p21 ras-derived synthetic peptides

1992 • 61 citations

Cellular immune response against tumor cells

1973 • 53 citations

Sensitivity of T cells to anti‐CD3‐stimulated suicide is independent of functional phenotype

1992 • 51 citations

Overlapping epitopes that are recognized by CD8+ HLA class I-restricted and CD4+ class II-restricted cytotoxic T lymphocytes are contained within an influenza nucleoprotein peptide.

1992 • 43 citations

Analysis of the association of peptides of optimal length to class I molecules on the surface of cells.

1992 • 35 citations

Characterization of a granule-independent lytic mechanism used by CTL hybridomas.

1994 • 35 citations

Presentation of antigen by mixed isotype class II molecules in normal H-2d mice.

1992 • 33 citations

The cytotoxic process of CD4 Th1 clones.

1992 • 32 citations

CD4+ T lymphocyte-induced target cell detachment. A model for T cell-mediated lytic and nonlytic inflammatory processes.

1991 • 29 citations

Mixed isotype class II antigen expression. A novel class II molecule is expressed on a murine B cell lymphoma.

1989 • 25 citations

Expression of class II major histocompatibility complex molecules correlates with human colon tumor vaccine efficacy.

1992 • 23 citations

Cytolytic activity of murine CD4+ T cell clones correlates with IFN-gamma production in mouse strains having a BALB/c background.

1993 • 19 citations

Heterogeneity in direct cytotoxic function of L3T4 T cells. TH1 clones express higher cytotoxic activity to antigen-presenting cells than TH2 clones.

1990 • 18 citations

A transient transfection system for identifying biosynthesized proteins processed and presented to class I MHC restricted T lymphocytes

1992 • 15 citations

Antigen-reactive T cell clones restricted by mixed isotype A beta d/E alpha d class II molecules.

1990 • 12 citations

Activated Val-12 ras p21 in cell culture fluids and mouse plasma.

1991 • 12 citations

Detachment and Lysis of Adherent Target Cells by CD4+ T Cell Clones Involve Multiple Effector Mechanisms

1993 • 11 citations