Dendritic Cell Based Therapy of Cancer

Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.

1994 • 5,204 citations

A Gene Encoding an Antigen Recognized by Cytolytic T Lymphocytes on a Human Melanoma

1991 • 3,493 citations

Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products.

1995 • 2,531 citations

Proliferating dendritic cell progenitors in human blood.

1994 • 1,922 citations

Vaccination of patients with B–cell lymphoma using autologous antigen–pulsed dendritic cells

1996 • 1,854 citations

Cells in Stress: Transcriptional Activation of Heat Shock Genes

1993 • 1,429 citations

Cloning of the gene coding for a shared human melanoma antigen recognized by autologous T cells infiltrating into tumor.

1994 • 1,108 citations

Bone marrow-derived dendritic cells pulsed with synthetic tumour peptides elicit protective and therapeutic antitumour immunity

1995 • 1,097 citations

Role of the Major Heat Shock Proteins as Molecular Chaperones

1993 • 1,096 citations

The tyrosinase gene codes for an antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas.

1993 • 986 citations

A new gene coding for a differentiation antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas.

1994 • 934 citations

Identification of a human melanoma antigen recognized by tumor-infiltrating lymphocytes associated with in vivo tumor rejection.

1994 • 921 citations

Inflammation, immunoregulation, and inducible nitric oxide synthase

1993 • 877 citations

Therapy of murine tumors with tumor peptide-pulsed dendritic cells: dependence on T cells, B7 costimulation, and T helper cell 1-associated cytokines.

1996 • 849 citations

Identification of a Peptide Recognized by Five Melanoma-Specific Human Cytotoxic T Cell Lines

1994 • 841 citations

A Mechanism for the Specific Immunogenicity of Heat Shock Protein-Chaperoned Peptides

1995 • 838 citations

Human gene MAGE-3 codes for an antigen recognized on a melanoma by autologous cytolytic T lymphocytes.

1994 • 771 citations

Peptide-pulsed dendritic cells induce antigen-specific CTL-mediated protective tumor immunity.

1996 • 746 citations

TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4−8+ T cells

1992 • 726 citations

A nonapeptide encoded by human gene MAGE-1 is recognized on HLA-A1 by cytolytic T lymphocytes directed against tumor antigen MZ2-E.

1992 • 694 citations

Human T, B, natural killer, and dendritic cells arise from a common bone marrow progenitor cell subset

1995 • 687 citations

Heat shock protein 70-associated peptides elicit specific cancer immunity.

1993 • 631 citations

Identification of human cancers deficient in antigen processing.

1993 • 625 citations

The tissue distribution of the B7-2 costimulator in mice: abundant expression on dendritic cells in situ and during maturation in vitro.

1994 • 607 citations

BAGE: a new gene encoding an antigen recognized on human melanomas by cytolytic T lymphocytes

1995 • 598 citations

A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma.

1995 • 591 citations

Melanocyte lineage-specific antigen gp100 is recognized by melanoma-derived tumor-infiltrating lymphocytes.

1994 • 584 citations

Heat shock proteins transfer peptides during antigen processing and CTL priming

1994 • 580 citations

Murine dendritic cells loaded in vitro with soluble protein prime cytotoxic T lymphocytes against tumor antigen in vivo.

1996 • 561 citations

Prostaglandins modulate macrophage Ia expression

1982 • 545 citations

Biologic Therapy of Cancer

1992 • 476 citations

Identification of proliferating dendritic cell precursors in mouse blood.

1992 • 445 citations

Two tyrosinase nonapeptides recognized on HLA‐A2 melanomas by autologous cytolytic T lymphocytes

1994 • 421 citations

Comparison of tumor-specific immunogenicities of stress-induced proteins gp96, hsp90, and hsp70.

1994 • 411 citations

A peptide encoded by human gene MAGE‐3 and presented by HLA‐A2 induces cytolytic T lymphocytes that recognize tumor cells expressing MAGE‐3

1994 • 379 citations

Bone marrow-generated dendritic cells pulsed with a class I-restricted peptide are potent inducers of cytotoxic T lymphocytes.

1995 • 372 citations

Perturbation of cellular calcium induces secretion of luminal ER proteins

1989 • 370 citations

Cellular requirements for tumor-specific immunity elicited by heat shock proteins: tumor rejection antigen gp96 primes CD8+ T cells in vivo.

1994 • 363 citations

Expansion of immunostimulatory dendritic cells among the myeloid progeny of human CD34+ bone marrow precursors cultured with c-kit ligand, granulocyte-macrophage colony-stimulating factor, and TNF-alpha.

1995 • 350 citations

Cross-priming of minor histocompatibility antigen-specific cytotoxic T cells upon immunization with the heat shock protein gp96.

1995 • 339 citations

International Surgery

2011 • 301 citations

Murine dendritic cells pulsed in vitro with tumor antigen induce tumor resistance in vivo

1994 • 300 citations

ERp99, an abundant, conserved glycoprotein of the endoplasmic reticulum, is homologous to the 90-kDa heat shock protein (hsp90) and the 94-kDa glucose regulated protein (GRP94).

1987 • 294 citations

Tumor rejection antigen gp96/grp94 is an ATPase: implications for protein folding and antigen presentation.

1993 • 293 citations

Identification of a gene encoding a melanoma tumor antigen recognized by HLA-A31-restricted tumor-infiltrating lymphocytes.

1995 • 282 citations

Therapy of murine tumors with p53 wild-type and mutant sequence peptide-based vaccines.

1996 • 262 citations

Recognition of tyrosinase by tumor-infiltrating lymphocytes from a patient responding to immunotherapy.

1994 • 247 citations

A peptide binding protein having a role in antigen presentation is a member of the HSP70 heat shock family.

1989 • 246 citations

Protective effects of hsp70 in inflammation

1994 • 241 citations

Autologous cytolytic T lymphocytes recognize a MAGE‐1 nonapeptide on melanomas expressing HLA‐Cw* 1601

1994 • 233 citations

A distinct pattern of cytokine gene expression by human CD83+ blood dendritic cells

1995 • 214 citations

Tumor antigen presentation by murine epidermal cells.

1991 • 211 citations

Induction of nitric oxide synthase in mouse dendritic cells by IFN-gamma, endotoxin, and interaction with allogeneic T cells: nitric oxide production is associated with dendritic cell apoptosis.

1996 • 210 citations

Mass spectrometric identification of a naturally processed melanoma peptide recognized by CD8+ cytotoxic T lymphocytes.

1995 • 208 citations

Evidence that granulocyte macrophage-colony-stimulating factor regulates the distribution and differentiated state of dendritic cells/Langerhans cells in human lung and lung cancers.

1993 • 198 citations

Inhibition of human macrophage colony formation by interleukin 4.

1989 • 173 citations

Melanoma cells and normal melanocytes share antigens recognized by HLA-A2-restricted cytotoxic T cell clones from melanoma patients.

1993 • 173 citations

Immunocytochemical Analysis of the Cellular Infiltrate in Primary Regressing and Non-Regressing Malignant Melanoma

1991 • 165 citations

S100 positive dendritic cells in human lung tumors associated with cell differentiation and enhanced survival

1993 • 160 citations

Generation of antimelanoma cytotoxic T lymphocytes from healthy donors after presentation of melanoma-associated antigen-derived epitopes by dendritic cells in vitro.

1995 • 157 citations

Follicular Dendritic Cell Tumors of the Oral Cavity

1994 • 139 citations

Human peripheral gamma delta T cells recognize hsp60 molecules on Daudi Burkitt's lymphoma cells.

1993 • 135 citations

Functional expression of CD40 antigen on human epidermal Langerhans cells.

1995 • 108 citations

Uptake of microparticle‐adsorbed protein antigen by bone marrow‐derived dendritic cells results in up‐regulation of interleukin‐1α and interleukin‐12 p40/p35 and triggers prolonged, efficient antigen presentation

1995 • 98 citations

Langerhans' Cell Counts and Cervical Intraepithelial Neoplasia in Women with Human Immunodeficiency Virus Infection

1993 • 97 citations

Langerhans Cells Related to Prognosis in Patients With Laryngeal Carcinoma

1991 • 90 citations

IL‐12‐Engineered Dendritic Cells Serve as Effective Tumor Vaccine Adjuvants in Vivoa

1996 • 86 citations

Influence of dendritic cells on tumor growth.

1985 • 84 citations

Understanding the dendritic cell lineage through a study of cytokine receptors.

1994 • 81 citations

Oral submucosal dendrocytes: factor XIIIa⁺ and CD34⁺ dendritic cell populations in normal tissue and fibrovascular lesions

1992 • 80 citations

Depressed monocyte polarization and clustering of dendritic cells in patients with head and neck cancer: In vitro restoration of this immunosuppression by thymic hormones

1993 • 76 citations

Differential expression of MAGE-1, -2, and -3 messenger RNA in transformed and normal human cell lines.

1993 • 61 citations

HLA-DR antigen- and S-100 protein-positive dendritic cells in esophageal squamous cell carcinoma— Their distribution in relation to prognosis

1992 • 60 citations

Variations in the Distribution, Frequency, and Phenotype of Langerhans Cells During the Evolution of Malignant Melanoma of the Skin

1993 • 54 citations

Correlations between histopathological and biological findings in nasopharyngeal carcinoma and its prognostic significance

1991 • 53 citations

Synergistic inhibition of human marrow granulocyte-macrophage progenitor cells by prostaglandin E and recombinant interferon-alpha, -beta, and -gamma and an effect mediated by tumor necrosis factor.

1988 • 52 citations

Distribution of langerhans cells and HLA class II molecules in prostatic carcinomas of different histopathological grade

1991 • 52 citations

Prognostic Significance of Accessory Cells and Lymphocytes in Nasopharyngeal Carcinoma

1991 • 50 citations

Relationship Between Types of Human Papillomavirus and Langerhans’ Cells in Cervical Condyloma and Intraepithelial Neoplasia

1993 • 49 citations

Reduction of Langerhans cells in smokeless tobacco‐associated oral mucosal lesions

1992 • 47 citations

Dendritic cell activity against primary tumors: an overview.

1993 • 47 citations

Follicular Dendritic Cells Have Prognostic Relevance in Hodgkin’s Disease

1994 • 43 citations

Roles of langerhans' cells and T-lymphocytes infiltrating cancer tissues in patients treated by radiation therapy for cervical cancer

1992 • 42 citations

In vivo modulation of myelopoiesis by prostaglandin E2. II. Inhibition of granulocyte-monocyte progenitor cell (CFU-GM) cell-cycle rate.

1987 • 41 citations

Diffuse sclerosing papillary carcinoma of the thyroid gland: immunohistochemical analysis of the local host immune response

1991 • 37 citations

Molecular chaperones in the processing and presentation of antigen to helper T cells

1994 • 35 citations

Macrophage and dendritic cell infiltration in head and neck squamous-cell carcinoma; an immunohistochemical study

1994 • 32 citations

CD28:B7 interactions promote T cell adhesion

1995 • 32 citations

Identification of potent mixed leukocyte reaction-stimulatory cells in human bone marrow. Putative differentiation stage of human blood dendritic cells.

1993 • 31 citations

Phenotype, genotype and cytokine production in acute leukemia involving progenitors of dendritic Langerhans' cells

1994 • 30 citations

Postoperative adjuvant immunochemotherapy and infiltration of dendritic cells for patients with advanced gastric cancer.

1992 • 27 citations

Dendritic cells prevent lymph node metastasis in patients with gastric cancer.

1993 • 26 citations

Infiltration of S-100 protein positive dendritic cells and peritoneal recurrence in advanced gastric cancer.

1992 • 24 citations

Exposure of monocytes to heat shock does not increase class II expression but modulates antigen-dependent T cell responses

1994 • 24 citations

Langerhans' Cells in Skin Tumors

1995 • 23 citations

Recognition of neuroectodermal tumors by melanoma-specific cytotoxic T lymphocytes: evidence for antigen sharing by tumors derived from the neural crest

1994 • 23 citations

The dendritic cell system and anti-tumour immunity.

1993 • 22 citations

Plasminogen activators and plasminogen activator inhibitors in human colorectal carcinoma tissues are not expressed by the tumour cells

1993 • 22 citations

Dendritic cells in various human thyroid diseases.

1993 • 20 citations

Dendritic cells in esophageal cancer and lymph node tissues.

1993 • 20 citations

Infiltration of dendritic cells into regional lymph nodes in gastric cancer

1995 • 19 citations

Epidermal Langerhans cells and prognosis of patients with mycosis fungoides and Sezary syndrome.

1993 • 19 citations

Variations in the Distribution, Frequency, and Phenotype of Langerhans Cells During the Evolution of Malignant Melanoma of the Skin.

1993 • 18 citations

Bronchiolo-alveolar carcinoma: An analysis of survival predictors

1992 • 18 citations

European Journal of Cancer

1966 • 18 citations

Lack of correlation between DNA ploidy, Langerhans cell population and grading in oral squamous cell carcinoma

1995 • 17 citations

Assessment by Planimetry of Langerhans’ Cell Density in Penile Epithelium with Human Papillomavirus Infection: Changes Observed After Topical Treatment

1992 • 17 citations

Density and morphology of Langerhans cells in basal cell carcinomas of the face and trunk

1992 • 17 citations

CD 1a and S100 antigen expression in skin Langerhans cells in patients with breast cancer

1991 • 16 citations

Tumor-immunotherapy with the use of tumor-antigen-pulsed antigen-presenting cells

1992 • 14 citations

Langerhans cell alterations in cutaneous carcinogenesis.

1993 • 14 citations

Dermal dendrocytes and T-cells in canine mycosis fungoides. Support for an animal model of human cutaneous T-cell lymphoma

1992 • 13 citations

Density and distribution of Langerhans cells in the human uterine cervix

1992 • 11 citations

Langerhans cells in epithelial tumors and benign lesions of the oropharynx.

1994 • 11 citations

Tobacco smoke condensate cutaneous carcinogenesis: changes in Langerhans' cells and tumour regression.

1995 • 10 citations

Langerhans cells and lymphocyte subsets in human gastrointestinal carcinomas

1992 • 8 citations

Langerhans cells and human papillomaviruses in oesophageal and laryngeal carcinomas.

1993 • 7 citations

Effect of epidermal Langerhans cells from melanoma patients on lymphoproliferative responses

1992 • 6 citations

Langerhans cells in epithelial skin tumors. A quantitative immunohistological and morphometric investigation.

1993 • 4 citations

Dendritic Cells in Tumor Growth and Endocrine Diseases

1993 • 4 citations

Dendrocyte Population in Cutaneous and Extracutaneous Kaposiʼs Sarcoma

1992 • 4 citations

Interdigitating Cells in the Peritumoral Infiltrate of Laryngeal Carcinomas: An Immunocytochemical and Ultrastructural Study

1991 • 3 citations

ADMINISTRATION OF FLT3 LIGAND RESULTS IN THE GENERATION OF LARGE NUMBERS OF PHENOTYPICALLY DISTINCT POPULATIONS OF DENDRITIC CELLS IN MICE

1996 • 3 citations

Epidemiological considerations in the role of dendritic/Langerhans cells in human cancer.

1993 • 2 citations

TNF alpha expressing cells in epidermal tumors: correlation with ICAM-1 induction on keratinocytes and Langerhans cell distribution.

1994 • 1 citations

Deleted Work

1955 • 0 citations