IL-12 is dispensable for innate and adaptive immunity against low doses of Listeria monocytogenes

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1983 • 52,849 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Development of T _H 1 CD4 ⁺ T Cells Through IL-12 Produced by Listeria -Induced Macrophages

1993 • 3,140 citations

Cloning of a new cytokine that induces IFN-γ production by T cells

1995 • 2,584 citations

Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes.

1989 • 1,989 citations

Immune Response in Mice that Lack the Interferon-γ Receptor

1993 • 1,570 citations

Immunity to Intracellular Bacteria

1993 • 1,085 citations

Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies.

1987 • 1,060 citations

IL-12-Deficient Mice Are Defective in IFNγ Production and Type 1 Cytokine Responses

1996 • 991 citations

Defective NK Cell Activity and Th1 Response in IL-18–Deficient Mice

1998 • 914 citations

Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist.

1993 • 792 citations

Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells.

1990 • 679 citations

Genetically resistant mice lacking interleukin‐12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response

1996 • 483 citations

Specific immunity to listeria monocytogenes in the absence of IFNγ

1995 • 432 citations

ESTERASE ACTIVITY IN LEUKOCYTES DEMONSTRATED BY THE USE OF NAPHTHOL AS-D CHLOROACETATE SUBSTRATE

1960 • 380 citations

Standardization of mRNA titration using a polymerase chain reaction method involving co-amplification with a multispecific internal control.

1992 • 342 citations

Neutralization of IL-12 decreases resistance to Listeria in SCID and C.B-17 mice. Reversal by IFN-gamma.

1994 • 305 citations

IL-4-deficient Balb/c mice resist infection with Leishmania major.

1996 • 273 citations

Studies with MHC-deficient knock-out mice reveal impact of both MHC I- and MHC II-dependent T cell responses on listeria monocytogenes infection

1995 • 244 citations

Presentation of Listeria monocytogenes to CD8+ T cells requires secretion of hemolysin and intracellular bacterial growth.

1990 • 208 citations

Both innate and acquired immunity to Listeria monocytogenes infection are increased in IL-10-deficient mice.

1997 • 202 citations

Studies with MHC-deficient knock-out mice reveal impact of both MHC I- and MHC II-dependent T cell responses on Listeria monocytogenes infection.

1994 • 201 citations

Monoclonal antibodies against murine gamma interferon.

1984 • 153 citations

Impaired macrophage listericidal and cytokine activities are responsible for the rapid death of Listeria monocytogenes-infected IFN-gamma receptor-deficient mice.

1997 • 152 citations

Secondary response to Listeria infection requires IFN-gamma but is partially independent of IL-12.

1995 • 90 citations

Primary and secondary immune responses to Listeria monocytogenes

1996 • 88 citations

METHOD FOR DEMONSTRATION OF SPIROCHAETA PALLIDA IN SINGLE MICROSCOPIC SECTIONS

1927 • 55 citations

Recombinant interleukin-12 enhances resistance of mice to Listeria monocytogenes infection

1994 • 53 citations

Analysis of the Interrelationship between IL-12, TNF-α, and IFN-γ/Production during Murine Listeriosis

1995 • 42 citations

Innate versus acquired immunity in listeriosis

1996 • 22 citations

Differential induction of IL12 synthesis by Mycobacterium bovis BCG and Listeria monocytogenes

1995 • 15 citations

Different stages in the natural and acquired resistance to an intracellular pathogen

1995 • 14 citations