Cutting Edge: Ectopic Expression of the IL-12 Receptor-β2 in Developing and Committed Th2 Cells Does Not Affect the Production of IL-4 or Induce the Production of IFN-γ

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

Functional diversity of helper T lymphocytes

1996 • 4,512 citations

Development of T _H 1 CD4 ⁺ T Cells Through IL-12 Produced by Listeria -Induced Macrophages

1993 • 3,140 citations

Interleukin-12: A Proinflammatory Cytokine with Immunoregulatory Functions that Bridge Innate Resistance and Antigen-Specific Adaptive Immunity

1995 • 2,437 citations

Lymphocyte responses and cytokines

1994 • 1,860 citations

Induction by Antigen of Intrathymic Apoptosis of CD4 ⁺ CD8 ⁺ TCR ^lo Thymocytes in Vivo

1990 • 1,781 citations

Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells.

1993 • 1,704 citations

Cytokines Induce the Development of Functionally Heterogeneous T Helper Cell Subsets

1998 • 1,569 citations

Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice

1996 • 1,277 citations

Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells

1996 • 1,182 citations

Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies.

1987 • 1,060 citations

Regulation of the Interleukin (IL)-12R β2 Subunit Expression in Developing T Helper 1 (Th1) and Th2 Cells

1997 • 1,022 citations

IL-12-Deficient Mice Are Defective in IFNγ Production and Type 1 Cytokine Responses

1996 • 991 citations

Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming.

1993 • 991 citations

Regulation of Immunity to Parasites by T Cells and T Cell-Derived Cytokines

1992 • 843 citations

Two types of mouse helper T-cell clone

1987 • 813 citations

Selective Expression of an Interleukin-12 Receptor Component by Human T Helper 1 Cells

1997 • 783 citations

IGIF Does Not Drive Th1 Development but Synergizes with IL-12 for Interferon-γ Production and Activates IRAK and NFκB

1997 • 726 citations

A functional interleukin 12 receptor complex is composed of two β-type cytokine receptor subunits

1996 • 690 citations

Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4.

1995 • 675 citations

Growth of a cloned helper T cell line induced by a monoclonal antibody specific for the antigen receptor: interleukin 1 is required for the expression of receptors for interleukin 2.

1984 • 529 citations

Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes.

1995 • 446 citations

Developmental commitment to the Th2 lineage by extinction of IL-12 signaling

1995 • 429 citations

Multistage Regulation of Th1-Type Immune Responses by the Transcription Factor IRF-1

1997 • 354 citations

Ectopic Expression of Activated Stat6 Induces the Expression of Th2-Specific Cytokines and Transcription Factors in Developing Th1 Cells

1999 • 300 citations

The Role of Stat4 in Species-Specific Regulation of Th Cell Development by Type I IFNs

1998 • 300 citations

Interferon Regulatory Factor-1 Is Required for a T Helper 1 Immune Response In Vivo

1997 • 286 citations

Cell-free activation of a DNA-binding protein by epidermal growth factor

1993 • 263 citations

Characterization of IL-12 receptor beta1 chain (IL-12Rbeta1)-deficient mice: IL-12Rbeta1 is an essential component of the functional mouse IL-12 receptor.

1997 • 211 citations

GATA-3 Significantly Downregulates IFN-γ Production from Developing Th1 Cells in Addition to Inducing IL-4 and IL-5 Levels

1999 • 172 citations

Antibodies to the IL-12 receptor beta 2 chain mark human Th1 but not Th2 cells in vitro and in vivo.

1999 • 140 citations

Antibodies to the IL-12 Receptor β2 Chain Mark Human Th1 But Not Th2 Cells In Vitro and In Vivo

1999 • 115 citations

The Ets transcription factor ERM is Th1-specific and induced by IL-12 through a Stat4-dependent pathway

1999 • 111 citations

Interferon-γ and interleukin-4 regulate T cell interleukin-12 responsiveness through the differential modulation of high-affinity interleukin-12 receptor expression

1997 • 82 citations

T Helper Differentiation Proceeds Through Stat1-Dependent, Stat4-Dependent and Stat4-Independent Phases

1999 • 81 citations

Lack of IL-12 signaling in human allergen-specific Th2 cells.

1996 • 64 citations

Immunoenzymetric Assay of Mouse and Human Cytokines Using <scp>NIP</scp>‐Labeled Anti‐Cytokine Antibodies

1995 • 34 citations

Immune‐Complex Assays for Tyrosine Protein Kinases

1993 • 14 citations