The Location of a Closed Channel Gate in the GABAA Receptor Channel

Refined Structure of the Nicotinic Acetylcholine Receptor at 4Å Resolution

2004 • 1,626 citations

Structure and gating mechanism of the acetylcholine receptor pore

2003 • 1,261 citations

Interaction of Tetraethylammonium Ion Derivatives with the Potassium Channels of Giant Axons

1971 • 930 citations

Emerging structure of the Nicotinic Acetylcholine receptors

2002 • 896 citations

Local anaesthetics transiently block currents through single acetylcholine‐receptor channels.

1978 • 864 citations

Rings of negatively charged amino acids determine the acetylcholine receptor channel conductance

1988 • 798 citations

Desensitized states prolong GABAA channel responses to brief agonist pulses

1995 • 592 citations

A point mutation in a Drosophila GABA receptor confers insecticide resistance

1993 • 552 citations

Mutations in the channel domain alter desensitization of a neuronal nicotinic receptor

1991 • 515 citations

Cys-loop receptors: new twists and turns

2004 • 426 citations

Identification of acetylcholine receptor channel-lining residues in the entire M2 segment of the α subunit

1994 • 418 citations

Evidence That the M2 Membrane-Spanning Region Lines the Ion Channel Pore of the Nicotinic Receptor

1988 • 379 citations

How quickly can GABAA receptors open?

1994 • 249 citations

Genetic manipulation of ion channels: A new approach to structure and mechanism

1989 • 223 citations

Trapping of Organic Blockers by Closing of Voltage-dependent K+ Channels

1997 • 211 citations

The Location of the Gate in the Acetylcholine Receptor Channel

1998 • 196 citations

On the mechanism of action of picrotoxin on GABA receptor channels in dissociated sympathetic neurones of the rat.

1992 • 193 citations

Identification of channel-lining residues in the M2 membrane-spanning segment of the GABA(A) receptor alpha1 subunit.

1996 • 193 citations

A unique amino acid of the Drosophila GABA receptor with influence on drug sensitivity by two mechanisms.

1994 • 160 citations

Desensitization of Mouse Nicotinic Acetylcholine Receptor Channels

1998 • 156 citations

Agonist-induced changes in the structure of the acetylcholine receptor M2 regions revealed by photoincorporation of an uncharged nicotinic noncompetitive antagonist.

1992 • 145 citations

Multiple mechanisms of picrotoxin block of GABA‐induced currents in rat hippocampal neurons.

1993 • 144 citations

Interaction of picrotoxin with GABAA receptor channel-lining residues probed in cysteine mutants

1995 • 143 citations

Point mutations in the M2 region of the alpha, beta, or gamma subunit of the GABAA channel that abolish block by picrotoxin.

1995 • 142 citations

Mapping the lipid-exposed regions in the Torpedo californica nicotinic acetylcholine receptor

1992 • 141 citations

Acetylcholine receptor channel structure in the resting, open, and desensitized states probed with the substituted-cysteine-accessibility method

2001 • 137 citations

State-dependent Accessibility and Electrostatic Potential in the Channel of the Acetylcholine Receptor

1998 • 108 citations

Site-specific fluorescence reveals distinct structural changes with GABA receptor activation and antagonism

2002 • 104 citations

Allosteric transitions of the acetylcholine receptor probed at the amino acid level with a photolabile cholinergic ligand.

1991 • 101 citations

Structural Determinants of Fast Desensitization and Desensitization–Deactivation Coupling in GABA_AReceptors

2001 • 97 citations

γ-Aminobutyric Acid Increases the Water Accessibility of M3 Membrane-Spanning Segment Residues in γ-Aminobutyric Acid Type A Receptors

1999 • 94 citations

GABAA Receptor M2–M3 Loop Secondary Structure and Changes in Accessibility during Channel Gating

2002 • 93 citations

A single amino acid in gamma-aminobutyric acid rho 1 receptors affects competitive and noncompetitive components of picrotoxin inhibition.

1995 • 92 citations

Subunit composition determines picrotoxin and bicuculline sensitivity of Drosophila gamma-aminobutyric acid receptors.

1995 • 84 citations

Structural and Electrostatic Properties of the 5-HT3Receptor Pore Revealed by Substituted Cysteine Accessibility Mutagenesis

2001 • 83 citations

Evidence for a Centrally Located Gate in the Pore of a Serotonin-Gated Ion Channel

2002 • 77 citations

Pore conformations and gating mechanism of a Cys-loop receptor

2005 • 71 citations

An Energy-Efficient Gating Mechanism in the Acetylcholine Receptor Channel Suggested by Molecular and Brownian Dynamics

2005 • 70 citations

Desensitization Mechanism of GABA Receptors Revealed by Single Oocyte Binding and Receptor Function

2002 • 69 citations

Contribution of the β Subunit M2 Segment to the Ion-Conducting Pathway of the Acetylcholine Receptor

1998 • 65 citations

Kinetics of open channel block by penicillin of single GABAA receptor channels from mouse spinal cord neurones in culture.

1992 • 58 citations

The β‐lactam antibiotics, penicillin‐G and cefoselis have different mechanisms and sites of action at GABA_A receptors

2002 • 53 citations

Benzodiazepines Induce a Conformational Change in the Region of the γ-Aminobutyric Acid Type A Receptor α₁-Subunit M3 Membrane-Spanning Segment

2000 • 52 citations

GABAA Receptor Structure–Function Studies: A Reexamination in Light of New Acetylcholine Receptor Structures

2004 • 50 citations

Mechanisms of channel gating of the ligand‐gated ion channel superfamily inferred from protein structure

2004 • 50 citations

Gating-enhanced Accessibility of Hydrophobic Sites within the Transmembrane Region of the Nicotinic Acetylcholine Receptor's δ-Subunit

2005 • 48 citations

Loose Protein Packing around the Extracellular Half of the GABAA Receptor β1 Subunit M2 Channel-lining Segment

2004 • 47 citations

Dual mechanisms of GABA_a response inhibition by β‐lactam antibiotics in the pyramidal neurones of the rat cerebral cortex

1995 • 47 citations

Local and Global Ligand-Induced Changes in the Structure of the GABA_A Receptor

2006 • 46 citations

Life at the Top: The Transition State of AChR Gating

2003 • 42 citations

Convulsant doses of penicillin shorten the lifetime of GABA‐induced channels in cultured central neurones

1986 • 38 citations

Two Novel Residues in M2 of the γ-Aminobutyric Acid Type A Receptor Affecting Gating by GABA and Picrotoxin Affinity

2001 • 36 citations

Block of Muscle Nicotinic Receptors by Choline Suggests that the Activation and Desensitization Gates Act as Distinct Molecular Entities

2006 • 35 citations

The α7 nicotinic acetylcholine receptor: Molecular modelling, electrostatics, and energetics

2005 • 34 citations

Desensitization of the Nicotinic Acetylcholine Receptor Mainly Involves a Structural Change in Solvent-Accessible Regions of the Polypeptide Backbone

1997 • 30 citations

Minimal Structural Rearrangement of the Cytoplasmic Pore during Activation of the 5-HT3A Receptor

2004 • 24 citations

Desensitization characteristics of rat recombinant GABA A receptors consisting of α 1 β 2 γ 2S and α 1 β 2 subunits expressed in HEK293 cells

2000 • 23 citations

Evidence for distinct conformations of the two α1 subunits in diazepam-bound GABAA receptors

2001 • 22 citations