Epidermal growth factor and platelet-derived growth factor induce expression of Egr-1, a zinc finger transcription factor, in human malignant glioma cells

Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin

1985 • 1,523 citations

A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization

1988 • 1,278 citations

A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicity.

1994 • 932 citations

Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification.

1987 • 843 citations

Genes for epidermal growth factor receptor, transforming growth factor alpha, and epidermal growth factor and their expression in human gliomas in vivo.

1991 • 634 citations

Epidermal growth factor receptors: critical mediators of multiple receptor pathways

1999 • 610 citations

Early Growth Response Protein 1 (Egr-1): Prototype of a Zinc-finger Family of Transcription Factors

1995 • 593 citations

The Enhanced Tumorigenic Activity of a Mutant Epidermal Growth Factor Receptor Common in Human Cancers Is Mediated by Threshold Levels of Constitutive Tyrosine Phosphorylation and Unattenuated Signaling

1997 • 591 citations

A constitutively active epidermal growth factor receptor cooperates with disruption of G₁ cell-cycle arrest pathways to induce glioma-like lesions in mice

1998 • 560 citations

The Nonamer UUAUUUAUU Is the Key AU-Rich Sequence Motif That Mediates mRNA Degradation

1995 • 524 citations

Amplification and/or overexpression of platelet-derived growth factor receptors and epidermal growth factor receptor in human glial tumors.

1992 • 380 citations

NAB2, a Corepressor of NGFI-A (Egr-1) and Krox20, Is Induced by Proliferative and Differentiative Stimuli

1996 • 353 citations

Expression of PDGF and PDGF receptors in human astrocytoma operation specimens supports the existence of an autocrine loop

1995 • 298 citations

Identification of NAB1, a repressor of NGFI-A- and Krox20-mediated transcription.

1995 • 258 citations

Functional characterization of an EGF receptor with a truncated extracellular domain expressed in glioblastomas with EGFR gene amplification.

1994 • 255 citations

Association of loss of heterozygosity on chromosome 17p with high platelet-derived growth factor alpha receptor expression in human malignant gliomas.

1996 • 228 citations

Regulation of synapsin I gene expression by the zinc finger transcription factor zif268/egr-1.

1994 • 203 citations

Egr-1 Activates Basic Fibroblast Growth Factor Transcription

1996 • 197 citations

Platelet‐derived growth factor in human glioma

1995 • 196 citations

Transformational and altered signal transduction by a naturally occurring mutant EGF receptor.

1996 • 195 citations

Detection and Quantification of Vascular Endothelial Growth Factor/Vascular Permeability Factor in Brain Tumor Tissue and Cyst Fluid

1994 • 165 citations

Selective amplification of the cytoplasmic domain of the epidermal growth factor receptor gene in glioblastoma multiforme.

1988 • 157 citations

Dominant-negative mutants of platelet-derived growth factor revert the transformed phenotype of human astrocytoma cells.

1993 • 155 citations

Gene amplification in human gliomas

1995 • 150 citations

Activation of the Ras/Mitogen-Activated Protein Kinase Pathway by Kinase-Defective Epidermal Growth Factor Receptors Results in Cell Survival but Not Proliferation

1998 • 115 citations

The human transcriptional repressor protein NAB1: expression and biological activity

2000 • 105 citations

Subsets of Epidermal Growth Factor Receptors during Activation and Endocytosis

1997 • 77 citations

Retinoic acid and the cyclin dependent kinase inhibitors synergistically alter proliferation and morphology of U343 astrocytoma cells

1997 • 64 citations

Expression of transforming growth factor alpha in human gliomas.

1990 • 62 citations

Advances in the molecular genetics of gliomas

1997 • 57 citations

Egr-1 gene is induced by the systemic administration of the vascular endothelial growth factor and the epidermal growth factor

2000 • 56 citations

Vascular Smooth Muscle Cells Express the Transcriptional Corepressor NAB2 in Response to Injury

1999 • 50 citations

Nerve growth factor- and epidermal growth factor-regulated gene transcription in PC12 pheochromocytoma and INS-1 insulinoma cells

2000 • 50 citations

PDGF-induced Egr-1 expression in rat mesangial cells is mediated through upstream serum response elements

1993 • 48 citations

Immunodetection of the Ligand-Activated Receptor for Epidermal Growth Factor

1991 • 34 citations

Epidermal growth factor induces Egr-1 messenger RNA and protein in mouse osteoblastic cells

1995 • 13 citations