Molecular characterization of the in vivo alkylating agent resistant murine EMT-6 mammary carcinoma tumors

p53 Mutations in Human Cancers

1991 • 8,133 citations

ras oncogenes in human cancer: a review.

1989 • 5,116 citations

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1993 • 2,969 citations

Association of Human Papillomavirus Types 16 and 18 E6 Proteins with p53

1990 • 2,587 citations

Redox Regulation of Fos and Jun DNA-Binding Activity in Vitro

1990 • 1,592 citations

The c-fos protein interacts with c-JunAP-1 to stimulate transcription of AP-1 responsive genes

1988 • 1,352 citations

Molecular Switch for Signal Transduction: Structural Differences Between Active and Inactive Forms of Protooncogenic ras Proteins

1990 • 1,037 citations

Oncogenes, antioncogenes, and the molecular bases of multistep carcinogenesis.

1989 • 961 citations

Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors.

1989 • 742 citations

Autoinduction of transforming growth factor beta 1 is mediated by the AP-1 complex.

1990 • 647 citations

Fos-Associated Protein p39 Is the Product of the jun Proto-Oncogene

1988 • 643 citations

p53 mutations increase resistance to ionizing radiation.

1993 • 573 citations

fos-associated cellular p39 is related to nuclear transcription factor AP-1

1988 • 508 citations

Tumor Suppressor Genes: The Puzzle and the Promise

1989 • 488 citations

Repression of c- fos Transcription and an Altered Genetic Program in Senescent Human Fibroblasts

1990 • 478 citations

p53 alteration is a common event in the spontaneous immortalization of primary BALB/c murine embryo fibroblasts.

1991 • 455 citations

Induction of protooncogene c-jun by serum growth factors.

1988 • 438 citations

Function of Ras as a molecular switch in signal transduction.

1992 • 425 citations

Nuclear Proto-Oncogenes Fos and Jun

1990 • 392 citations

Tumor Resistance to Alkylating Agents Conferred by Mechanisms Operative Only in Vivo

1990 • 313 citations

Ionizing radiation regulates expression of the c-jun protooncogene.

1990 • 297 citations

Epidermal growth factor stimulates transcription of the c-jun proto-oncogene in rat fibroblasts

1988 • 289 citations

Immune response to p53 is dependent upon p53/HSP70 complexes in breast cancers.

1992 • 281 citations

Microinjection of fos-specific antibodies blocks DNA synthesis in fibroblast cells.

1988 • 266 citations

Activation of ras Oncogenes Preceding the Onset of Neoplasia

1990 • 261 citations

Inherited p53 gene mutations in breast cancer.

1992 • 255 citations

Expression and purification of the leucine zipper and DNA-binding domains of Fos and Jun: both Fos and Jun contact DNA directly.

1990 • 245 citations

p53 mutations in breast cancer.

1992 • 243 citations

Differential expression of the c-erbB-2 gene in human small cell and non-small cell lung cancer

1990 • 233 citations

c-Ha-ras oncogene expression in immortalized human keratinocytes (HaCaT) alters growth potential in vivo but lacks correlation with malignancy.

1990 • 212 citations

Relationship between the formation of promutagenic adducts and the activation of the K-ras protooncogene in lung tumors from A/J mice treated with nitrosamines

1990 • 210 citations

Induction of fos RNA by DNA-damaging agents.

1989 • 209 citations

Effect of Antisense c- raf -1 on Tumorigenicity and Radiation Sensitivity of a Human Squamous Carcinoma

1989 • 189 citations

c-fos expression induces bone tumors in transgenic mice.

1989 • 177 citations

Synergistic effect of the v-myc oncogene with H-ras on radioresistance.

1990 • 174 citations

Transcriptional and post-transcriptional regulation of c-jun expression during monocytic differentiation of human myeloid leukemic cells.

1990 • 169 citations

Increased resistance to cis-diamminedichloroplatinum(II) in NIH 3T3 cells transformed by ras oncogenes.

1988 • 156 citations

Alkylating agents: in vitro studies of cross-resistance patterns in human cell lines.

1986 • 156 citations

The role of the H-ras oncogene in radiation resistance and metastasis

1990 • 145 citations

EGF Receptor anderbB-2 Tyrosine Kinase Domains Confer Cell Specificity for Mitogenic Signaling

1990 • 142 citations

Increased erbB-2 gene copies and expression in multiple stages of breast cancer.

1990 • 134 citations

K-ras activation in neoplasms of the human female reproductive tract.

1990 • 130 citations

Characterization of c-Ki-ras and N-ras oncogenes in aflatoxin B1-induced rat liver tumors.

1990 • 126 citations

Elevated expression of the c-myc oncoprotein correlates with poor prognosis in head and neck squamous cell carcinoma.

1989 • 125 citations

The neu (c-erbB-2) oncogene.

1989 • 120 citations

Heparin suppresses the induction of c-fos and c-myc mRNA in murine fibroblasts by selective inhibition of a protein kinase C-dependent pathway.

1989 • 116 citations

The oncogene jun and nuclear signalling

1989 • 107 citations

Molecular basis of cisplatin resistance in human carcinomas: model systems and patients.

1989 • 106 citations

Presence of Two Members of c-erbA Receptor Gene Family (c-erbAbeta and c-erbA2) in Smallest Region of Somatic Homozygosity on Chromosome 3p21-p25 in Human Breast Carcinoma

1989 • 99 citations

Autoinduction of Transforming Growth Factor β1 Is Mediated by the AP-1 Complex

1990 • 99 citations

Elevated expression of thymidylate synthase cycle genes in cisplatin-resistant human ovarian carcinoma A2780 cells.

1988 • 98 citations

Tumor resistance to alkylating agents conferred by mechanisms operative only in vivo

1990 • 96 citations

Differences between normal and ras-transformed NIH-3T3 cells in expression of the 170kD and 180kD forms of topoisomerase II.

1990 • 91 citations

Two oncogenes, v-fos and v-ras, cooperate to convert normal keratinocytes to squamous cell carcinoma.

1990 • 87 citations

Expression of the c-Ha-ras oncogene in mouse NIH 3T3 cells induces resistance to cisplatin.

1991 • 86 citations

Identification of a membrane glycoprotein overexpressed in murine lymphoma sublines resistant to cis-diamminedichloroplatinum(II).

1990 • 85 citations

‘Nuclear’ oncogenes convert extracellular stimuli into changes in the genetic program

1989 • 83 citations

Inverse correlation between expression of multidrug resistance gene and N-myc oncogene in human neuroblastomas.

1990 • 77 citations

Embryonic stem (ES) cells lacking functional c-jun: consequences for growth and differentiation, AP-1 activity and tumorigenicity.

1992 • 74 citations

Amplification of c-myc but not of c-erbB-2 is associated with high proliferative capacity in breast cancer.

1993 • 73 citations

Coupled and uncoupled induction of fos and jun transcription by different second messengers in cells of hematopoietic origin

1990 • 73 citations

Alkalinization of the lysosomes is correlated with ras transformation of murine and human fibroblasts.

1990 • 67 citations

Overexpression of DNA replication and repair enzymes in cisplatin-resistant human colon carcinoma HCT8 cells and circumvention by azidothymidine.

1989 • 63 citations

Expression of Transfected Recombinant Oncogenes Increases Radiation Resistance of Clonal Hematopoietic and Fibroblast Cell Lines Selectively at Clinical Low Dose Rate

1990 • 61 citations

Loss of the MYC gene amplified in human HL-60 cells after treatment with inhibitors of poly(ADP-ribose) polymerase or with dimethyl sulfoxide.

1989 • 58 citations

Activated ras genes in human seminoma: evidence for tumor heterogeneity.

1989 • 53 citations

Microinjection of fos-Specific Antibodies Blocks DNA Synthesis in Fibroblast Cells

1988 • 52 citations

c-myc and c-fos gene regulation during mouse liver regeneration.

1989 • 48 citations

Development of alkylating agent-resistant human tumor cell lines

1988 • 48 citations

Analysis of the int-1, int-2, c-myc, and neu oncogenes in human breast carcinomas.

1990 • 47 citations

Altered expression of wild-type p53 tumor suppressor gene during murine epithelial cell transformation.

1992 • 35 citations

Neoplastic transformation and tumorigenesis by the human protooncogene MYC.

1990 • 34 citations

An immunohistochemical analysis ofras oncogene expression in epithelial neoplasms of the colon

1990 • 26 citations

Elevation of c-myc protein by DNA strand breakage.

1989 • 26 citations

Temporally defined induction of c-fos in the rat pineal

1990 • 25 citations

Amplification of N-myc and ornithine decarboxylase genes in human neuroblastoma and hydroxyurea-resistant hamster cell lines.

1989 • 23 citations

Changes in c-myc and c-fos expression in a human tumor cell line following exposure to bifunctional alkylating agents.

1990 • 22 citations

Amplification of the c-myc oncogene during progression of radiation-induced rat skin tumors.

1990 • 21 citations

c-Ha-ras-I oncogene-induced differentiation and natural killer cell resistance in a human colorectal carcinoma cell line.

1990 • 20 citations

Stress response genes induced in mammalian cells by ionizing radiation

1993 • 19 citations

Protection of bone-marrow granulocyte-macrophage colony-forming units in mice bearing in vivo alkylating-agent-resistant EMT-6 tumors

1993 • 18 citations

Fos and jun: two into one will go.

1990 • 17 citations

Coamplification of the L‐myc and N‐myc Oncogenes in a Neuroblastoma Cell Line

1989 • 15 citations

ras gene activation in rat tumors induced by benzidine congeners and derived dyes.

1990 • 14 citations

Reversible suppression of c-myc expression in a human colon carcinoma line by the anticancer agent N-methylformamide.

1989 • 14 citations

Increased phosphorylation of nuclear phosphoproteins in human lung‐cancer cells resistant to cis‐diamminedichloroplatinum(II)

1992 • 14 citations

The N-myc gene product in primary retinoblastomas

1989 • 10 citations

Amplification of N-myc and ornithine decarboxylase genes in human neuroblastoma and hydroxyurea-resistant hamster cell lines.

1989 • 10 citations

Prognostic significance of "short-term" effects of chemotherapy on MYC and histone H3 mRNA levels in acute leukemia patients.

1988 • 10 citations

The effect of cisplatin and carboplatin on c-myc promoter in erythroleukemic cells

1991 • 3 citations

Deleted Work

1955 • 0 citations