‘Nuclear’ oncogenes convert extracellular stimuli into changes in the genetic program

ras GENES

1987 • 3,818 citations

Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor

1987 • 3,057 citations

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

1983 • 2,871 citations

The Molecular Genetics of Cancer

1987 • 1,729 citations

Fos and jun: The AP-1 connection

1988 • 1,597 citations

Human Proto-Oncogene c- jun Encodes a DNA Binding Protein with Structural and Functional Properties of Transcription Factor AP-1

1987 • 1,353 citations

The c-fos protein interacts with c-JunAP-1 to stimulate transcription of AP-1 responsive genes

1988 • 1,352 citations

c-Jun dimerizes with itself and with c-Fos, forming complexes of different DNA binding affinities

1988 • 1,084 citations

Oncogene jun encodes a sequence-specific trans- activator similar to AP-1

1988 • 940 citations

DNA binding activities of three murine Jun proteins: Stimulation by Fos

1988 • 850 citations

A c-myc antisense oligodeoxynucleotide inhibits entry into S phase but not progress from G0 to G1

1987 • 696 citations

Requirement for c-ras proteins during viral oncogene transformation

1986 • 680 citations

Requirement for fos gene expression in the transcriptional activation of collagenase by other oncogenes and phorbol esters

1988 • 597 citations

Functional role for c-myc in mitogenic response to platelet-derived growth factor

1984 • 578 citations

GENETICS OF HUMAN CANCER

1986 • 565 citations

Fos and Jun bind cooperatively to the AP-1 site: reconstitution in vitro.

1988 • 511 citations

Antisense RNA of proto-oncogene c-fos blocks renewed growth of quiescent 3T3 cells.

1987 • 381 citations

Altered growth regulation and enhanced tumorigenicity of NIH 3T3 fibroblasts transfected with protein kinase C-I cDNA

1988 • 285 citations

DNA-bound Fos proteins activate transcription in yeast

1988 • 223 citations

Flat revertants isolated from Kirsten sarcoma virus-transformed cells are resistant to the action of specific oncogenes.

1983 • 221 citations

Dissecting Multistep Tumorigenesis in Transgenic Mice

1988 • 215 citations

A Harvey-ras responsive transcription element is also responsive to a tumour-promoter and to serum

1988 • 187 citations

v-erbA cooperates with sarcoma oncogenes in leukemic cell transformation

1986 • 156 citations

The c-Ha-ras oncogene and a tumor promoter activate the polyoma virus enhancer

1987 • 129 citations

Microinjection of Transforming ras protein induces c-fos Expression

1987 • 123 citations

Towards an understanding of the malignant transformation of diploid human fibroblasts

1988 • 121 citations

Microinjection of ras p21 Induces a Rapid Rise in Intracellular pH

1987 • 100 citations

Revertants of v-fos-transformed fibroblasts have mutations in cellular genes essential for transformation by other oncogenes

1987 • 82 citations

Microinjection of ras p21 induces a rapid rise in intracellular pH.

1987 • 78 citations

Microinjection of transforming ras protein induces c-fos expression.

1987 • 78 citations

The major ras induced protein in NIH3T3 cells is cathepsin L

1987 • 46 citations

Regulation of gene expression in the adipocyte: implications for obesity and proto-oncogene function

1988 • 35 citations

Antisense RNA to the C-fos gene: Restoration of density-dependent growth arrest in a transformed cell line

1987 • 35 citations

Constitutive expression of c-fos antisense RNA blocks c-fos gene induction by interferon and by phorbol ester and reduces c-myc expression in F9 embryonal carcinoma cells.

1988 • 27 citations