Reggie-1/flotillin-2 promotes secretion of the long-range signalling forms of Wingless and Hedgehog in Drosophila

A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila

2007 • 2,649 citations

Wnt proteins are lipid-modified and can act as stem cell growth factors

2003 • 2,209 citations

Exosomes: endosomal-derived vesicles shipping extracellular messages

2004 • 982 citations

The FLP recombinase of yeast catalyzes site-specific recombination in the drosophila genome

1989 • 939 citations

Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling

2005 • 852 citations

Organizing activity of wingless protein in Drosophila

1993 • 852 citations

Identification of a Palmitic Acid-modified Form of Human Sonic hedgehog

1998 • 735 citations

Monounsaturated Fatty Acid Modification of Wnt Protein: Its Role in Wnt Secretion

2006 • 732 citations

Wntless, a Conserved Membrane Protein Dedicated to the Secretion of Wnt Proteins from Signaling Cells

2006 • 729 citations

Lipid rafts: heterogeneity on the high seas

2004 • 689 citations

Lipoprotein particles are required for Hedgehog and Wingless signalling

2005 • 678 citations

Gradient Formation of the TGF-β Homolog Dpp

2000 • 606 citations

Dispatched, a Novel Sterol-Sensing Domain Protein Dedicated to the Release of Cholesterol-Modified Hedgehog from Signaling Cells

1999 • 571 citations

Secretion of Wnt Ligands Requires Evi, a Conserved Transmembrane Protein

2006 • 563 citations

Autoproteolysis in hedgehog protein biogenesis

1994 • 541 citations

Hedgehog Patterning Activity: Role of a Lipophilic Modification Mediated by the Carboxy-Terminal Autoprocessing Domain

1996 • 529 citations

Senseless, a Zn Finger Transcription Factor, Is Necessary and Sufficient for Sensory Organ Development in Drosophila

2000 • 509 citations

A freely diffusible form of Sonic hedgehog mediates long-range signalling

2001 • 485 citations

Argosomes

2001 • 413 citations

Hedgehog Creates a Gradient of DPP Activity in Drosophila Wing Imaginal Discs

2000 • 402 citations

Kinetics of Morphogen Gradient Formation

2007 • 398 citations

Hedgehog Controls Limb Development by Regulating the Activities of Distinct Transcriptional Activator and Repressor Forms of Cubitus interruptus

1999 • 374 citations

Measuring dimensions: the regulation of size and shape

2000 • 358 citations

Morpheus Unbound: Reimagining the Morphogen Gradient

2007 • 329 citations

Hedgehog-Mediated Patterning of the Mammalian Embryo Requires Transporter-like Function of Dispatched

2002 • 327 citations

Association of Sterol- and Glycosylphosphatidylinositol-linked Proteins with Drosophila Raft Lipid Microdomains

1999 • 320 citations

[3] Comparative analysis of mammalian plasma lipoproteins

1986 • 318 citations

Scaffolding microdomains and beyond: the function of reggie/flotillin proteins

2005 • 311 citations

Glycosaminoglycans can modulate extracellular localization of the wingless protein and promote signal transduction.

1996 • 307 citations

The Drosophila cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathways

1995 • 275 citations

ThreeDrosophilaEXT genes shape morphogen gradients through synthesis of heparan sulfate proteoglycans

2003 • 274 citations

Wingless and Notch regulate cell-cycle arrest in the developing Drosophila wing

1998 • 263 citations

The SPFH domain: implicated in regulating targeted protein turnover in stomatins and other membrane-associated proteins

1999 • 248 citations

Drosophila Wnt-1 Undergoes a Hydrophobic Modification and Is Targeted to Lipid Rafts, a Process That Requires Porcupine

2004 • 243 citations

Control of the nuclear localization of Extradenticle by competing nuclear import and export signals

1999 • 232 citations

Secreted int-1 protein is associated with the cell surface.

1990 • 215 citations

Reggie/flotillin proteins are organized into stable tetramers in membrane microdomains

2007 • 194 citations

Control of growth and organ size in Drosophila

2002 • 178 citations

Drosophila Segment Polarity Gene Product Porcupine Stimulates the Posttranslational N-Glycosylation of Wingless in the Endoplasmic Reticulum

2002 • 172 citations

The COE transcription factor Collier is a mediator of short-range Hedgehog-induced patterning of the Drosophila wing

1999 • 164 citations

Helping Wingless take flight: how WNT proteins are secreted

2007 • 141 citations

The making of Wnt: new insights into Wnt maturation, sorting and secretion

2006 • 131 citations

Wnt/Wingless signaling through beta-catenin requires the function of both LRP/Arrow and frizzled classes of receptors.

2003 • 129 citations

Apical Localization of wingless Transcripts Is Required for Wingless Signaling

2001 • 125 citations

Function and regulation of homothorax in the wing imaginai disc of Drosophila

2000 • 124 citations

RNA Interference of Gene Expression (RNAi) in Cultured Drosophila Cells

2001 • 122 citations

A Drosophila Axin homolog, Daxin, inhibits Wnt signaling

1999 • 122 citations

wingless refines its own expression domain on the Drosophila wing margin

1996 • 116 citations

Producing Cells Retain and Recycle Wingless in Drosophila Embryos

2002 • 108 citations

Arrow (LRP6) and Frizzled2 cooperate to degrade Wingless inDrosophilaimaginal discs

2005 • 76 citations

Lipid Modification of Secreted Signaling Proteins

2006 • 67 citations

Morphogens: how big is the big picture?

2001 • 61 citations

Preformed reggie/flotillin caps: stable priming platforms for macrodomain assembly in T cells

2006 • 56 citations

Loss- and gain-of-function analysis of the lipid raft proteins Reggie/Flotillin in Drosophila: They are posttranslationally regulated, and misexpression interferes with wing and eye development

2005 • 51 citations

The 'lipid raft' microdomain proteins reggie-1 and reggie-2 (flotillins) are scaffolds for protein interaction and signalling.

2005 • 50 citations

A screen for genes expressed in Drosophila imaginal discs.

2002 • 48 citations