Drosophila Wnt-1 Undergoes a Hydrophobic Modification and Is Targeted to Lipid Rafts, a Process That Requires Porcupine

Functional rafts in cell membranes

1997 • 9,471 citations

Wnt proteins are lipid-modified and can act as stem cell growth factors

2003 • 2,209 citations

Isolation of intracellular membranes by means of sodium carbonate treatment: application to endoplasmic reticulum.

1982 • 1,765 citations

Fatty acylation of proteins: new insights into membrane targeting of myristoylated and palmitoylated proteins

1999 • 1,236 citations

The Promise and Perils of Wnt Signaling Through β-Catenin

2002 • 959 citations

Identification of a Palmitic Acid-modified Form of Human Sonic hedgehog

1998 • 735 citations

The Wnt signalling pathway

2002 • 534 citations

Wnt Signaling Polarizes an Early C. elegans Blastomere to Distinguish Endoderm from Mesoderm

1997 • 525 citations

Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion

1998 • 505 citations

A freely diffusible form of Sonic hedgehog mediates long-range signalling

2001 • 485 citations

A superfamily of membrane-bound O -acyltransferases with implications for Wnt signaling

2000 • 477 citations

Skinny Hedgehog, an Acyltransferase Required for Palmitoylation and Activity of the Hedgehog Signal

2001 • 462 citations

Distribution of the wingless gene product in drosophila embryos: A protein involved in cell-cell communication

1989 • 452 citations

Inhibition of Protein Palmitoylation, Raft Localization, and T Cell Signaling by 2-Bromopalmitate and Polyunsaturated Fatty Acids

2000 • 452 citations

SNARE proteins are highly enriched in lipid rafts in PC12 cells: Implications for the spatial control of exocytosis

2001 • 420 citations

The Drosophila Wnt, Wingless, Provides an Essential Signal for Pre- and Postsynaptic Differentiation

2002 • 416 citations

Argosomes

2001 • 413 citations

Hedgehog Movement Is Regulated through tout velu–Dependent Synthesis of a Heparan Sulfate Proteoglycan

1999 • 367 citations

Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface

2003 • 339 citations

The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing.

1996 • 337 citations

Association of Sterol- and Glycosylphosphatidylinositol-linked Proteins with Drosophila Raft Lipid Microdomains

1999 • 320 citations

Glycosaminoglycans can modulate extracellular localization of the wingless protein and promote signal transduction.

1996 • 307 citations

Role of palmitoylation/depalmitoylation reactions in G-protein-coupled receptor function

2002 • 255 citations

Mutations in the segment polarity genes wingless and porcupine impair secretion of the wingless protein.

1993 • 254 citations

Secretion and movement of wingless protein in the epidermis of the Drosophila embryo

1991 • 244 citations

New Insights into the Mechanisms of Protein Palmitoylation

2003 • 200 citations

Cholesterol Modification of Hedgehog Is Required for Trafficking and Movement, Revealing an Asymmetric Cellular Response to Hedgehog

2003 • 180 citations

Protein and lipid sorting from thetrans–Golgi network to the plasma membrane in polarized cells

1998 • 179 citations

High-Resolution Separation and Quantification of Neutral Lipid and Phospholipid Species in Mammalian Cells and Sera by Multi-One-Dimensional Thin-Layer Chromatography

1998 • 174 citations

Drosophila Segment Polarity Gene Product Porcupine Stimulates the Posttranslational N-Glycosylation of Wingless in the Endoplasmic Reticulum

2002 • 172 citations

Cholesterol Depletion of Enterocytes

2000 • 141 citations

The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family

2000 • 120 citations

Cholesterol modification of Hedgehog family proteins

2002 • 100 citations

2-Bromopalmitoyl-CoA and 2-bromopalmitate: Promiscuous inhibitors of membrane-bound enzymes

1992 • 96 citations

Cholesterol modification of Hedgehog family proteins

2002 • 84 citations

Hsp90 Interactions and Acylation Target the G Protein Gα12 but Not Gα13 to Lipid Rafts

2002 • 80 citations

Wnts as morphogens? The view from the wing of Drosophila

2003 • 68 citations

Inducible overexpression and secretion of int-1 protein.

1989 • 62 citations

Lipid composition of subcellular membranes from larvae and prepupae ofDrosophila melanogaster

1992 • 61 citations

Molecular cloning and initial characterization of the MG61/PORC gene, the human homologue of the Drosophila segment polarity gene Porcupine

2002 • 58 citations

Posttranslational protein S-palmitoylation and the compartmentalization of signaling molecules in neurons

2002 • 35 citations

Argosomes: membrane fragments on the run

2002 • 27 citations

A role for palmitoylation in the quality control, assembly and secretion of apolipoprotein B

2004 • 13 citations

Misexpression of mouse porcupine isoforms modulates the differentiation of P19 embryonic carcinoma cells

2003 • 6 citations