The making of Wnt: new insights into Wnt maturation, sorting and secretion

THE WNT SIGNALING PATHWAY IN DEVELOPMENT AND DISEASE

2004 • 5,114 citations

Wnt signaling: a common theme in animal development

1997 • 2,579 citations

Wnt proteins are lipid-modified and can act as stem cell growth factors

2003 • 2,209 citations

MECHANISMS OF WNT SIGNALING IN DEVELOPMENT

1998 • 2,028 citations

Linking Colorectal Cancer to Wnt Signaling

2000 • 1,507 citations

LDL receptor-related proteins 5 and 6 in Wnt/β-catenin signaling:Arrows point the way

2004 • 990 citations

The Promise and Perils of Wnt Signaling Through β-Catenin

2002 • 959 citations

Direct and Long-Range Action of a Wingless Morphogen Gradient

1996 • 736 citations

Wntless, a Conserved Membrane Protein Dedicated to the Secretion of Wnt Proteins from Signaling Cells

2006 • 729 citations

A Membrane Coat Complex Essential for Endosome-to-Golgi Retrograde Transport in Yeast

1998 • 716 citations

Lipoprotein particles are required for Hedgehog and Wingless signalling

2005 • 678 citations

Roles of lipid rafts in membrane transport

2001 • 623 citations

Role of the mammalian retromer in sorting of the cation-independent mannose 6-phosphate receptor

2004 • 587 citations

Unexpected complexity of the Wnt gene family in a sea anemone

2005 • 579 citations

Secretion of Wnt Ligands Requires Evi, a Conserved Transmembrane Protein

2006 • 563 citations

Wnt Signaling Polarizes an Early C. elegans Blastomere to Distinguish Endoderm from Mesoderm

1997 • 525 citations

A morphogen gradient of Wnt/β-catenin signalling regulates anteroposterior neural patterning inXenopus

2001 • 504 citations

Wnt signaling: complexity at the surface

2006 • 490 citations

Distribution of the wingless gene product in drosophila embryos: A protein involved in cell-cell communication

1989 • 452 citations

Wingless gradient formation in the Drosophila wing

2000 • 437 citations

Long-range action of Wingless organizes the dorsal-ventral axis of the Drosophila wing

1997 • 416 citations

Do Morphogen Gradients Arise by Diffusion?

2002 • 403 citations

Endosome to Golgi Retrieval of the Vacuolar Protein Sorting Receptor, Vps10p, Requires the Function of the VPS29, VPS30, and VPS35 Gene Products

1997 • 393 citations

Spatial expression of the Drosophila segment polarity gene armadillo is posttranscriptionally regulated by wingless

1990 • 374 citations

Heparan sulfate proteoglycans are critical for the organization of the extracellular distribution of Wingless

2001 • 370 citations

Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface

2003 • 339 citations

The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing.

1996 • 337 citations

Interactions of misfolded influenza virus hemagglutinin with binding protein (BiP).

1989 • 312 citations

The on–off story of protein palmitoylation

2002 • 311 citations

Mutations in the segment polarity genes wingless and porcupine impair secretion of the wingless protein.

1993 • 254 citations

Wnt Gradient Formation Requires Retromer Function in Wnt-Producing Cells

2006 • 253 citations

Secretion and movement of wingless protein in the epidermis of the Drosophila embryo

1991 • 244 citations

Drosophila Wnt-1 Undergoes a Hydrophobic Modification and Is Targeted to Lipid Rafts, a Process That Requires Porcupine

2004 • 243 citations

HSPG Modification by the Secreted Enzyme Notum Shapes the Wingless Morphogen Gradient

2002 • 238 citations

You Wnt some, you lose some: oncogenes in the Wnt signaling pathway

2003 • 233 citations

Wnt signaling establishes anteroposterior neuronal polarity and requires retromer inC. elegans

2006 • 222 citations

Heavy-chain binding protein recognizes aberrant polypeptides translocated in vitro

1988 • 219 citations

Drosophilaglypicans Dally and Dally-like shape the extracellular Wingless morphogen gradient in the wing disc

2005 • 216 citations

Opposing Activities of Dally-like Glypican at High and Low Levels of Wingless Morphogen Activity

2004 • 213 citations

Sorting of Yeast Membrane Proteins into an Endosome-to-Golgi Pathway Involves Direct Interaction of Their Cytosolic Domains with Vps35p

2000 • 195 citations

Cholesterol Modification of Hedgehog Is Required for Trafficking and Movement, Revealing an Asymmetric Cellular Response to Hedgehog

2003 • 180 citations

Neuronal cell migration in C. elegans: regulation of Hox gene expression and cell position

1996 • 175 citations

Drosophila Segment Polarity Gene Product Porcupine Stimulates the Posttranslational N-Glycosylation of Wingless in the Endoplasmic Reticulum

2002 • 172 citations

Spatial Regulation of Wingless Morphogen Distribution and Signaling by Dally-like Protein

2004 • 164 citations

The mammalian retromer regulates transcytosis of the polymeric immunoglobulin receptor

2004 • 138 citations

Protruding Vulva Mutants Identify Novel Loci and Wnt Signaling Factors That Function During Caenorhabditis elegans Vulva Development

2000 • 119 citations

Lipid Raft Association of Carboxypeptidase E Is Necessary for Its Function as a Regulated Secretory Pathway Sorting Receptor

2000 • 118 citations

Mutational analysis of mouse Wnt-1 identifies two temperature-sensitive alleles and attributes of Wnt-1 protein essential for transformation of a mammary cell line.

1992 • 109 citations

Producing Cells Retain and Recycle Wingless in Drosophila Embryos

2002 • 108 citations

Alternative pathways for the sorting of soluble vacuolar proteins in yeast: a vps35 null mutant missorts and secretes only a subset of vacuolar hydrolases.

1992 • 100 citations

Regulating morphogen gradients in the Drosophila wing

2002 • 97 citations

Biochemical Analysis of Murine Wnt Proteins Reveals both Shared and Distinct Properties

1995 • 96 citations

Morphogen Transport along Epithelia, an Integrated Trafficking Problem

2002 • 82 citations

Regulated Apical Secretion of Zymogens in Rat Pancreas

2001 • 78 citations

Release and trafficking of lipid-linked morphogens

2005 • 66 citations

Transport and assembly processes in the endoplasmic reticulum.

1990 • 61 citations

Interaction of Wnt-1 proteins with the binding protein BiP.

1992 • 47 citations

int-1--a proto-oncogene involved in cell signalling.

1989 • 46 citations

The int-1 proto-oncogene is transcriptionally activated during neuroectodermal differentiation of P19 mouse embryonal carcinoma cells.

1989 • 32 citations

Heparan Sulfate Proteoglycans are critical for the organization of the extracellular distribution of Wingless

2001 • 31 citations