Distinct roles of type I bone morphogenetic protein receptors in the formation and differentiation of cartilage

Novel Regulators of Bone Formation: Molecular Clones and Activities

1988 • 3,919 citations

Bone morphogenetic proteins: multifunctional regulators of vertebrate development.

1996 • 1,959 citations

Regulation of Rate of Cartilage Differentiation by Indian Hedgehog and PTH-Related Protein

1996 • 1,952 citations

A series of normal stages in the development of the chick embryo

1992 • 1,860 citations

PTH/PTHrP Receptor in Early Development and Indian Hedgehog—Regulated Bone Growth

1996 • 1,303 citations

Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene.

1994 • 1,138 citations

Expression of a Delta homologue in prospective neurons in the chick

1995 • 1,019 citations

Laboratory methods in histotechnology

1992 • 911 citations

Receptor-associated Mad homologues synergize as effectors of the TGF-β response

1996 • 874 citations

Limb alterations in brachypodism mice due to mutations in a new member of the TGFβ-superfamily

1994 • 855 citations

TGFβ Signaling: Receptors, Transducers, and Mad Proteins

1996 • 840 citations

Sonic hedgehog and Fgf-4 act through a signaling cascade and feedback loop to integrate growth and patterning of the developing limb bud

1994 • 801 citations

MADR2 Is a Substrate of the TGFβ Receptor and Its Phosphorylation Is Required for Nuclear Accumulation and Signaling

1996 • 740 citations

Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4.

1994 • 737 citations

Recombinant human bone morphogenetic protein-2 stimulates osteoblastic maturation and inhibits myogenic differentiation in vitro.

1991 • 735 citations

MADR1, a MAD-Related Protein That Functions in BMP2 Signaling Pathways

1996 • 710 citations

Toward a molecular understanding of skeletal development

1995 • 683 citations

GS domain mutations that constitutively activate T beta R-I, the downstream signaling component in the TGF-beta receptor complex.

1995 • 682 citations

A human Mad protein acting as a BMP-regulated transcriptional activator

1996 • 674 citations

Adaptor plasmids simplify the insertion of foreign DNA into helper-independent retroviral vectors

1987 • 651 citations

Involvement of Bone Morphogenetic Protein-4 (BMP-4) and Vgr-1 in morphogenesis and neurogenesis in the mouse

1991 • 646 citations

Organogenesis and pattern formation in the mouse: RNA distribution patterns suggest a role for Bone Morphogenetic Protein-2A (BMP-2A)

1990 • 616 citations

Stage-related capacity for limb chondrogenesis in cell culture

1977 • 616 citations

Human Type II Receptor for Bone Morphogenic Proteins (BMPs): Extension of the Two-Kinase Receptor Model to the BMPs

1995 • 602 citations

The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase.

1997 • 569 citations

Characterization of Type I Receptors for Transforming Growth Factor-β and Activin

1994 • 558 citations

Requirement for BMP Signaling in Interdigital Apoptosis and Scale Formation

1996 • 552 citations

Cloning and characterization of a human type II receptor for bone morphogenetic proteins.

1995 • 551 citations

The signalling molecule BMP4 mediates apoptosis in the rhombencephalic neural crest

1994 • 486 citations

Targeted overexpression of parathyroid hormone-related peptide in chondrocytes causes chondrodysplasia and delayed endochondral bone formation.

1996 • 471 citations

Bone morphogenetic proteins and a signalling pathway that controls patterning in the developing chick limb

1994 • 465 citations

Patterns of expression of murine Vgr-1 and BMP-2a RNA suggest that transforming growth factor-beta-like genes coordinately regulate aspects of embryonic development.

1989 • 440 citations

Cartilage-derived morphogenetic proteins. New members of the transforming growth factor-beta superfamily predominantly expressed in long bones during human embryonic development.

1994 • 415 citations

Characterization and Cloning of a Receptor for BMP-2 and BMP-4 from NIH 3T3 Cells

1994 • 368 citations

Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity.

1993 • 354 citations

Chapter 10 Manipulating Gene Expression with Replication--Competent Retroviruses

1996 • 344 citations

Role of BMP-2 and OP-1 (BMP-7) in programmed cell death and skeletogenesis during chick limb development

1997 • 339 citations

Distinct spatial and temporal expression patterns of two type I receptors for bone morphogenetic proteins during mouse embryogenesis.

1995 • 326 citations

Characterization and relationship of dpp receptors encoded by the saxophone and thick veins genes in Drosophila

1994 • 317 citations

What do BMPs do in mammals? Clues from the mouse short-ear mutation

1994 • 300 citations

Receptor serine/threonine kinases implicated in the control of Drosophila body pattern by decapentaplegic

1994 • 275 citations

Overexpression of BMP-2 and BMP-4 alters the size and shape of developing skeletal elements in the chick limb

1996 • 265 citations

Characterization and Developmental Expression of Pax9, a Paired-Box-Containing Gene Related to Pax1

1995 • 263 citations

Identification of a Human Type II Receptor for Bone Morphogenetic Protein-4 That Forms Differential Heteromeric Complexes with Bone Morphogenetic Protein Type I Receptors

1995 • 238 citations

BMP-2/-4 mediate programmed cell death in chicken limb buds

1996 • 228 citations

Serine/threonine kinase receptors: mediators of transforming growth factor beta family signals.

1996 • 197 citations

The developmentally regulated type X collagen gene contains a long open reading frame without introns.

1986 • 188 citations

BMP signaling during bone pattern determination in the developing limb

1996 • 180 citations

Compartments and appendage development in Drosophila

1995 • 175 citations

Enhanced expression of type I receptors for bone morphogenetic proteins during bone formation

1995 • 174 citations

Molecular basis of morphogenesis

1993 • 151 citations

Bone Morphogenetic Protein-2 (BMP-2) Inhibits Muscle Development and Promotes Cartilage Formation in Chick Limb Bud Cultures

1996 • 116 citations

Expression of genes encoding bone morphogenetic proteins and sonic hedgehog in talpid (ta³) limb buds: Their relationships in the signalling cascade involved in limb patterning

1995 • 113 citations

In Situ Hybridization Analysis of the Expression of the Type II Collagen Gene in the Developing Chicken Limb Bud

1988 • 75 citations

Signaling through both type I DPP receptors is required for anterior-posterior patterning of the entire Drosophila wing

1997 • 75 citations

Distinct spatial and temporal expression patterns of two type I receptors for bone morphogenetic proteins during mouse embryogenesis

1995 • 70 citations

Molecular cloning and expression of bone morphogenetic protein-7 in the chick epiphyseal growth plate

1994 • 60 citations

Chicken parathyroid hormone-related protein and its expression during embryologic development

1991 • 49 citations

The independence of myogenesis and chondrogenesis in micromass cultures of chick wing buds

1986 • 32 citations

The Inhibitory Effect of 5‐Bromodeoxyuridine on the Programmed Cell Death in the Chick Limb

1983 • 29 citations

A new receptor protein kinase from chick embryo related to type II receptor for TGF-β

1993 • 17 citations