The Main Immunogenic Region of the Acetylcholine Receptor. Structure and Role in Myasthenia Gravis

Use of peptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid.

1984 • 1,467 citations

Antibody to acetylcholine receptor in myasthenia gravis

1998 • 1,149 citations

Antibody to acetylcholine receptor in myasthenia gravis: Prevalence, clinical correlates, and diagnostic value

1976 • 1,123 citations

Autoimmune Response to Acetylcholine Receptor

1973 • 1,019 citations

Primary structure of α-subunit precursor of Torpedo californica acetylcholine receptor deduced from cDNA sequence

1982 • 730 citations

Neuromuscular Junction in Myasthenia Gravis: Decreased Acetylcholine Receptors

1973 • 633 citations

Acetylcholine Receptor: An Allosteric Protein

1984 • 620 citations

Monoclonal antibodies used to probe acetylcholine receptor structure: localization of the main immunogenic region and detection of similarities between subunits.

1980 • 452 citations

Mapping of surface structures of electrophorus acetylcholine receptor using monoclonal antibodies.

1981 • 412 citations

Functional Activities of Autoantibodies to Acetylcholine Receptors and the Clinical Severity of Myasthenia Gravis

1982 • 384 citations

Specificities of antibodies to acetylcholine receptors in sera from myasthenia gravis patients measured by monoclonal antibodies.

1982 • 342 citations

Myasthenia Gravis

1988 • 341 citations

Amino acids of the Torpedo marmorata acetylcholine receptor .alpha. subunit labeled by a photoaffinity ligand for the acetylcholine binding site

1988 • 314 citations

Functional Expression of a New Pharmacological Subtype of Brain Nicotinic Acetylcholine Receptor

1988 • 314 citations

The ion channel of the nicotinic acetylcholine receptor is formed by the homologous helices M II of the receptor subunits

1986 • 313 citations

Receptors and Recognition

1976 • 288 citations

Myasthenia gravis and myasthenic syndromes.

1992 • 248 citations

Genes expressed in the brain define three distinct neuronal nicotinic acetylcholine receptors.

1988 • 232 citations

Structure of the high-affinity binding site for noncompetitive blockers of the acetylcholine receptor: [3H]chlorpromazine labels homologous residues in the .beta. and .delta. chains

1987 • 228 citations

Autoimmune human T lymphocytes specific for acetylcholine receptor

1984 • 224 citations

Pathological mechanisms in experimental autoimmune myasthenia gravis. II. Passive transfer of experimental autoimmune myasthenia gravis in rats with anti-acetylcholine recepotr antibodies.

1976 • 218 citations

Localization of the main immunogenic region of human muscle acetylcholine receptor to residues 67-76 of the alpha subunit.

1988 • 215 citations

Molecular studies of the neuronal nicotinic acetylcholine receptor family

1987 • 203 citations

Myasthenia gravis induced by monoclonal antibodies to acetylcholine receptors

1980 • 201 citations

Modulation of acetylcholine receptor by antibody against the receptor

1977 • 201 citations

Location of subunits within the acetylcholine receptor by electron image analysis of tubular crystals from Torpedo marmorata.

1987 • 195 citations

A muscle acetylcholine receptor is expressed in the human cerebellar medulloblastoma cell line TE671

1989 • 186 citations

The Molecular Neurobiology of the Acetylcholine Receptor

1986 • 186 citations

Transmembrane topography of the nicotinic acetylcholine receptor: immunochemical tests contadict theoretical predictions based on hydrophobicity profiles

1986 • 183 citations

Passive transfer of experimental autoimmune myasthenia gravis by monoclonal antibodies to the main immunogenic region of the acetylcholine receptor

1987 • 172 citations

Mapping the Main Immunogenic Region and Toxin-Binding Site of the Nicotinic Acetylcholine Receptor

1987 • 161 citations

Characterization of the human cell line TE671

1989 • 161 citations

Establishment of a human medulloblastoma cell line

1977 • 161 citations

Monoclonal antibodies as probes of acetylcholine receptor structure. 2. Binding to native receptor

1981 • 157 citations

Location of antigenic determinants of primary sequences of the subunits of nicotinic acetylcholine receptor by peptide mapping

1986 • 146 citations

Demonstration of a main immunogenic region on acetylcholine receptors from human muscle using monoclonal antibodies to human receptor

1983 • 139 citations

Molecular Structure of the Nicotinic Acetylcholine Receptor

1983 • 138 citations

Molecular mimicry and myasthenia gravis. An autoantigenic site of the acetylcholine receptor alpha-subunit that has biologic activity and reacts immunochemically with herpes simplex virus.

1989 • 137 citations

Pathogenesis of myasthenia gravis. Acetylcholine receptor-related antigenic determinants in tumor-free thymuses and thymic epithelial tumors.

1988 • 129 citations

Anti-acetylcholine receptor antibodies directed against the alpha-bungarotoxin binding site induce a unique form of experimental myasthenia.

1983 • 127 citations

Characteristics of monoclonal antibodies to denatured Torpedo and to native calf acetylcholine receptors: Species, subunit and region specificity

1986 • 127 citations

Organization of ligand binding sites at the acetylcholine receptor: a study with monoclonal antibodies

1983 • 116 citations

MONOCLONAL AUTOANTIBODIES TO ACETYLCHOLINE RECEPTORS: EVIDENCE FOR A DOMINANT IDIORPE AND REQUIREMENT OF COMPLEMENT FOR PATHOGENICITY*

1981 • 116 citations

Monoclonal antibodies as probes of acetylcholine receptor structure. 1. Peptide mapping

1981 • 115 citations

Humoral Pathogenesis of Myasthenia Grayis^a

1987 • 111 citations

Role of the main immunogenic region of acetylcholine receptor in myasthenia gravis. An Fab monoclonal antibody protects against antigenic modulation by human sera.

1985 • 106 citations

Immunohistochemical localization of monoclonal antibodies to the nicotinic acetylcholine receptor in chick midbrain.

1983 • 105 citations

Evidence for unpredicted transmembrane domains in acetylcholine receptor subunits.

1985 • 103 citations

Human T-helper lymphocytes in myasthenia gravis recognize the nicotinic receptor alpha subunit.

1987 • 100 citations

Synthetic peptides used to locate the .alpha.-bungarotoxin binding site and immunogenic regions on .alpha. subunits of the nicotinic acetylcholine receptor

1987 • 95 citations

Regulation of acetylcholine receptor transcript expression during development in Xenopus laevis

1988 • 93 citations

STRUCTURE AND FUNCTION OF THE ACETYLCHOLINE RECEPTOR MOLECULE STUDIED USING MONOCLONAL ANTIBODIES

1981 • 90 citations

Structure and transmembrane nature of the acetylcholine receptor in amphibian skeletal muscle as revealed by cross-reacting monoclonal antibodies.

1984 • 90 citations

Monoclonal antibodies to the main immunogenic region of the nicotinic acetylcholine receptor bind to residues 61-76 of the alpha subunit.

1988 • 73 citations

T-cell reactivity in myasthenia gravis

1989 • 72 citations

Monoclonal antibodies directed against the neurotransmitter binding site of nicotinic acetylcholine receptor

1980 • 70 citations

The acetylcholine receptor molecule: allosteric sites and the ion channel

1987 • 68 citations

Identification of exposed and buried determinants of the membrane-bound acetylcholine receptor from Torpedo californica

1981 • 67 citations

Affinity labeling of neuronal acetylcholine receptor subunits with an alpha-neurotoxin that blocks receptor function.

1987 • 66 citations

Synthesis and assembly of acetylcholine receptor, a multisubunit membrane glycoprotein

1986 • 65 citations

Determination of amino acids critical to the main immunogenic region of intact acetylcholine receptors by in vitro mutagenesis

1990 • 64 citations

Fine localization of the major alpha-bungarotoxin binding site to residues alpha 189-195 of the Torpedo acetylcholine receptor. Residues 189, 190, and 195 are indispensable for binding.

1990 • 63 citations

Intrathymic pathogenesis of myasthenia gravis: transient expression of acetylcholine receptors on thymus‐derived myogenic cells

1978 • 63 citations

Canine and human myasthenia gravis autoantibodies recognize similar regions on the acetylcholine receptor

1988 • 57 citations

Fab fragments of monoclonal antibodies protect the human acetylcholine receptor against antigenic modulation caused by myasthenic sera

1989 • 56 citations

Characterization of the binding of alpha-bungarotoxin to bacterially expressed cholinergic binding sites.

1988 • 54 citations

Epitope mapping employing antibodies raised against short synthetic peptides: a study of the nicotinic acetylcholine receptor

1989 • 53 citations

Structure and Function of the Nicotinic Acetylcholine Receptor

1988 • 50 citations

Myasthenia gravis

1986 • 49 citations

The main immunogenic region of the nicotinic acetylcholine receptor. Identification of amino acid residues interacting with different antibodies.

1989 • 49 citations

Evidence against acetylcholine receptor having a main immunogenic region as target for autoantibodies in myasthenia gravis

1989 • 49 citations

Interaction of monoclonal antibodies to torpedo acetylcholine receptor with the receptor of skeletal muscle

1983 • 48 citations

Profile of the continuous antigenic regions on the extracellular part of the alpha chain of an acetylcholine receptor.

1987 • 46 citations

Epitopes on Human Acetylcholine Receptor Defined by Monoclonal Antibodies and Myasthenia Gravis Sera

1988 • 43 citations

Conformation of cytoplasmic segments of acetylcholine receptor alpha- and beta-subunits probed by monoclonal antibodies: sensitivity of the antibody competition approach.

1987 • 42 citations

Antigenic modulation of human myotube acetylcholine receptor by myasthenic sera. Serum titer determines receptor internalization rate.

1986 • 42 citations

Myasthenic serum selectively blocks acetylcholine receptors with long channel open times at developing rat endplates.

1985 • 41 citations

Antigenic role of single residues within the main immunogenic region of the nicotinic acetylcholine receptor

1990 • 41 citations

Effects of monoclonal antibodies on the function of acetylcholine receptors purified from Torpedo californica and reconstituted into vesicles

1985 • 41 citations

The Biochemistry of Myasthenia Gravis and Muscular Dystrophy

1979 • 40 citations

T cell epitopes in experimental autoimmune myasthenia gravis of the rat: strain‐specific epitopes and cross‐reaction between two distinct segments of the α chain of the nicotinic acetylcholine receptor (torpedo californica)

1988 • 40 citations

Main Immunogenic Region of Torpedo Electroplax and Human Muscle Acetylcholine Receptor: Localization and Microheterogeneity Revealed by the Use of Synthetic Peptides

1990 • 39 citations

Antigenic sites of the nicotinic acetylcholine receptor cannot be predicted from the hydrophilicity profile

1984 • 39 citations

Experimental autoimmune myasthenia gravis.

1980 • 37 citations

Localization of a highly immunogenic region on the acetylcholine receptor α-subunit

1986 • 35 citations

Monoclonal antibodies as probes of the alpha-bungarotoxin and cholinergic binding regions of the acetylcholine receptor.

1987 • 34 citations

Anti‐acetylcholine receptor antibody specificities in serum and in thymic cell culture supernatants from myasthenia gravis patients

1988 • 34 citations

The main immunogenic region of the nicotinic acetylcholine receptor: Interaction of monoclonal antibodies with synthetic peptides

1989 • 34 citations

Decrease in acetylcholine‐receptor content of human myotube cultures mediated by monoclonal antibodies to α, β and γ subunits

1986 • 34 citations

Identification of a novel nicotinic acetylcholine receptor structural subunit expressed in goldfish retina.

1989 • 33 citations

Identification of a cytoplasmic region of the Torpedo nicotinic acetylcholine receptor alpha-subunit by epitope mapping.

1990 • 32 citations

Fine antigenic specificities of antibodies in sera from patients with D-penicillamine-induced myasthenia gravis.

1988 • 32 citations

Proteolytic fragments of the nicotinic acetylcholine receptor identified by mass spectrometry: implications for receptor topography

1989 • 31 citations

Monoclonal antibodies with defined specificities for Torpedo nicotinic acetylcholine receptor cross-react with Drosophila neural tissue

1987 • 29 citations

Localisation of the main immunogenic region of the nicotinic acetylcholine receptor

1986 • 25 citations

Monoclonal antibodies against the main immunogenic region of the acetylcholine receptor

1989 • 24 citations

The main immunogenic region of acetylcholine receptors does not provoke the formation of antibodies of a predominant idiotype

1985 • 22 citations

B-T lymphocyte interactions in experimental autoimmune myasthenia gravis: antigen presentation by ratlmouse hybridoma lines secreting monoclonal antibodies against the nicotinic acetylcholine receptor

1988 • 20 citations

Interaction of monoclonal antibodies to electroplaque acetylcholine receptors with the α-bungarotoxin binding site of goldfish brain

1986 • 20 citations

Two‐dimensional ¹H‐nmr study of synthetic peptides containing the main immunogenic region of the Torpedo acetylcholine receptor

1989 • 18 citations

Sharing of Epitopes by Bacteria and the Nicotinic Acetylcholine Receptor: A Possible Role in the Pathogenesis of Myasthenia Gravis

1987 • 17 citations

Myasthenia gravis studied by monoclonal antibodies to the acetylcholine receptor.

1988 • 16 citations

Paratope- and framework-related cross-reactive idiotopes on anti-acetylcholine receptor antibodies.

1991 • 16 citations

Basic Features of Cellular Interactions in the Immune System^a

1987 • 16 citations

Anti-acetylcholine receptor antibody related idiotypes in myasthenia gravis

1988 • 16 citations

Epitopes on human acetylcholine receptor α-subunit: binding of monoclonal antibodies to recombinant and synthetic peptides

1989 • 14 citations

Monoclonal antibodies to receptors : probes for receptor structure and function

1984 • 14 citations

Binding and blocking antibodies to the human acetylcholine receptor: Are they selected in various myasthenia gravis forms?

1988 • 10 citations

Studying the Acetylcholine Receptor with Monoclonal Antibodies

1991 • 9 citations

Antibodies to the Acetylcholine Receptor

1984 • 7 citations

Determination of antibody binding sites on the three-dimensional and primary structure of acetylcholine receptor.

1988 • 5 citations

Fine Structural Characterization of the Main Immunogenic Region of the Nicotinic Acetylcholine Receptor

1989 • 5 citations

Experimental autoimmune myasthenia gravis : antibodies, idiotypes, and anti-idiotypes

1989 • 3 citations

Mapping of the Alpha‐Bungarotoxin Binding Site on the Primary Amino Acid Sequence of the Torpedo Acetylcholine Receptor

1986 • 2 citations

Membrane proteins: Structure, function, assembly

1989 • 1 citations