Monoclonal antibodies against the main immunogenic region of the acetylcholine receptor

Monoclonal antibodies used to probe acetylcholine receptor structure: localization of the main immunogenic region and detection of similarities between subunits.

1980 • 452 citations

Mapping of surface structures of electrophorus acetylcholine receptor using monoclonal antibodies.

1981 • 412 citations

Specificities of antibodies to acetylcholine receptors in sera from myasthenia gravis patients measured by monoclonal antibodies.

1982 • 342 citations

Myasthenia Gravis

1988 • 341 citations

[29] Production and assay of antibodies to acetylcholine receptors

1981 • 277 citations

Localization of the main immunogenic region of human muscle acetylcholine receptor to residues 67-76 of the alpha subunit.

1988 • 215 citations

Molecular studies of the neuronal nicotinic acetylcholine receptor family

1987 • 203 citations

Location of subunits within the acetylcholine receptor by electron image analysis of tubular crystals from Torpedo marmorata.

1987 • 195 citations

Transmembrane topography of the nicotinic acetylcholine receptor: immunochemical tests contadict theoretical predictions based on hydrophobicity profiles

1986 • 183 citations

Passive transfer of experimental autoimmune myasthenia gravis by monoclonal antibodies to the main immunogenic region of the acetylcholine receptor

1987 • 172 citations

Mapping the Main Immunogenic Region and Toxin-Binding Site of the Nicotinic Acetylcholine Receptor

1987 • 161 citations

Monoclonal antibodies as probes of acetylcholine receptor structure. 2. Binding to native receptor

1981 • 157 citations

Location of antigenic determinants of primary sequences of the subunits of nicotinic acetylcholine receptor by peptide mapping

1986 • 146 citations

Demonstration of a main immunogenic region on acetylcholine receptors from human muscle using monoclonal antibodies to human receptor

1983 • 139 citations

Characteristics of monoclonal antibodies to denatured Torpedo and to native calf acetylcholine receptors: Species, subunit and region specificity

1986 • 127 citations

Monoclonal antibodies as probes of acetylcholine receptor structure. 1. Peptide mapping

1981 • 115 citations

Conditions for the selective labelling of the 66 000 dalton chain of the acetylcholine receptor by the covalent non‐competitive blocker 5‐azido‐[³H]trimethisoquin

1980 • 111 citations

Role of the main immunogenic region of acetylcholine receptor in myasthenia gravis. An Fab monoclonal antibody protects against antigenic modulation by human sera.

1985 • 106 citations

Identification of a nicotinic acetylcholine receptor on neurons using an alpha-neurotoxin that blocks receptor function

1986 • 82 citations

Monoclonal antibodies to the main immunogenic region of the nicotinic acetylcholine receptor bind to residues 61-76 of the alpha subunit.

1988 • 73 citations

The acetylcholine receptor molecule: allosteric sites and the ion channel

1987 • 68 citations

Synthesis and assembly of acetylcholine receptor, a multisubunit membrane glycoprotein

1986 • 65 citations

Structure and Function of the Nicotinic Acetylcholine Receptor

1988 • 50 citations

Conformation of cytoplasmic segments of acetylcholine receptor alpha- and beta-subunits probed by monoclonal antibodies: sensitivity of the antibody competition approach.

1987 • 42 citations

Decrease in acetylcholine‐receptor content of human myotube cultures mediated by monoclonal antibodies to α, β and γ subunits

1986 • 34 citations

Myasthenia gravis: biology and treatment.

1987 • 32 citations

B-T lymphocyte interactions in experimental autoimmune myasthenia gravis: antigen presentation by ratlmouse hybridoma lines secreting monoclonal antibodies against the nicotinic acetylcholine receptor

1988 • 20 citations

Myasthenia gravis studied by monoclonal antibodies to the acetylcholine receptor.

1988 • 16 citations

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