Antibodies to the Acetylcholine Receptor

Continuous cultures of fused cells secreting antibody of predefined specificity

1975 • 17,037 citations

Autoimmune Response to Acetylcholine Receptor

1973 • 1,019 citations

Control of acetylcholine receptors in skeletal muscle

1979 • 770 citations

Primary structure of α-subunit precursor of Torpedo californica acetylcholine receptor deduced from cDNA sequence

1982 • 730 citations

Acetylcholine Receptor: Complex of Homologous Subunits

1980 • 594 citations

Primary structures of β- and δ-subunit precursors of Torpedo californica acetylcholine receptor deduced from cDNA sequences

1983 • 527 citations

The Nicotinic Cholinergic Receptor: Correlation of Molecular Structure with Functional Properties

1982 • 456 citations

Monoclonal antibodies used to probe acetylcholine receptor structure: localization of the main immunogenic region and detection of similarities between subunits.

1980 • 452 citations

Myasthenic Antibodies Cross-Link Acetylcholine Receptors to Accelerate Degradation

1978 • 425 citations

The Harvey Lectures . Delivered under the Auspices of The Harvey Society of New York, 1906-4, by Professors A. E. Wright, C. A. Herter, W. T. Porter, J. G. Adami, F. G. Benedict, E. B. Wilson, George S. Huntington, W. T. Councilman, Friedrioh Muller and Dr. S. J. Meltzer. Pp. 1414 Philadelphia and London, J. B. Lippincott Company. 1908.

1908 • 422 citations

Nucleotide and deduced amino acid sequences of Torpedo californica acetylcholine receptor gamma subunit.

1983 • 412 citations

Molecular weight in detergent solution of acetylcholine receptor from Torpedo californica

1978 • 384 citations

The Cell surface and neuronal function

1980 • 379 citations

Serum Globulin in Myasthenia Gravis: Inhibition of α-Bungarotoxin Binding to Acetylcholine Receptors

1974 • 365 citations

Muscle development--molecular and cellular control

1982 • 344 citations

Myasthenia Gravis

1978 • 341 citations

An electrophysiological investigation of neuro‐muscular transmission in myasthenia gravis

1964 • 333 citations

Experimental autoimmune myasthenia: A model of myasthenia gravis in rats and guinea pigs.

1975 • 325 citations

EXPERIMENTAL AUTOIMMUNE MYASTHENIA GRAVIS AND MYASTHENIA GRAVIS: BIOCHEMICAL AND IMMUNOCHEMICAL ASPECTS*

1976 • 275 citations

Acetylcholine Receptors

1972 • 273 citations

The output of sympathetic amines from the cat's adrenal gland in response to splanchnic nerve activity

1961 • 271 citations

The distribution of α‐bungarotoxin binding sites on mammalian skeletal muscle developing in vivo

1977 • 266 citations

Immunology of acetylcholine receptors in relation to myasthenia gravis.

1980 • 255 citations

Thymic Muscle Cells Bear Acetylcholine Receptors: Possible Relation to Myasthenia Gravis

1977 • 244 citations

Affinity-labeling of purified acetylcholine receptor from Torpedo californica

1974 • 243 citations

Biochemical properties of acetylcholine receptor subunits from Torpedo californica

1979 • 239 citations

Myasthenia gravis induced by monoclonal antibodies to acetylcholine receptors

1980 • 201 citations

Modulation of acetylcholine receptor by antibody against the receptor

1977 • 201 citations

Immunological distinction between acetylcholine receptor and the alpha-bungarotoxin-binding component on sympathetic neurons.

1977 • 199 citations

Active multi-subunit ACh receptor assembled by translation of heterologous mRNA in Xenopus oocytes

1981 • 197 citations

The acetylcholine sensitivity of frog muscle fibres after complete or partial denervation

1960 • 196 citations

Studies of the composition of purified Torpedo californica acetylcholine receptor and of its subunits

1979 • 193 citations

Molecular forms of acetylcholine receptor. Effects of calcium ions and a sulfhydryl reagent on the occurrence of oligomers

1977 • 185 citations

Structural studies of a membrane-bound acetylcholine receptor from Torpedo californica

1977 • 183 citations

The molecular cloning and characterisation of cDNA coding for the α subunit of the acetyl-choline receptor

1982 • 176 citations

Pathological mechanisms in experimental autoimmune myasthenia gravis. I. Immunogenicity of syngeneic muscle acetylcholine receptor and quantitative extraction of receptor and antibody-receptor complexes from muscles of rats with experimental automimmune myasthenia gravis.

1976 • 175 citations

Plasmapheresis and the Immunobiology of Myasthenia Gravis

1979 • 168 citations

Monoclonal antibodies to the acetylcholine receptor by a normally functioning auto-anti-idiotypic mechanism

1983 • 162 citations

Purification fromTorpedo marmorata electric tissue of membrane fragments particularly rich in cholinergic receptor protein

1972 • 160 citations

Bromoacetylcholine as an affinity label of the acetylcholine receptor from Torpedo californica

1978 • 160 citations

Acetylcholine receptor metabolism in a nonfusing muscle cell line.

1977 • 160 citations

Monoclonal antibodies as probes of acetylcholine receptor structure. 2. Binding to native receptor

1981 • 157 citations

Anti-idiotypic route to anti-acetylcholine receptor antibodies and experimental myasthenia gravis.

1982 • 156 citations

Immunospecific identification and three-dimensional structure of a membrane-bound acetylcholine receptor from Torpedo californica

1979 • 153 citations

Accelerated degradation of acetylcholine receptor from cultured rat myotubes with myasthenia gravis sera and globulins.

1977 • 150 citations

HUMORAL ANTIBODIES TO ACETYLCHOLINE RECEPTOR IN PATIENTS WITH MYASTHENIA GRAVIS

1975 • 148 citations

Studies on Purified Eel Acetylcholine Receptor and Anti-Acetylcholine Receptor Antibody

1973 • 148 citations

In vitro synthesis, glycosylation, and membrane insertion of the four subunits of Torpedo acetylcholine receptor.

1981 • 147 citations

Autoimmune Response to Acetylcholine Receptors in Myasthenia Gravis and Its Animal Model

1979 • 143 citations

Facets of the Structures of Acetylcholine Receptors from Electrophorus and Torpedo

1976 • 142 citations

Immunization of rats with polypeptide chains from torpedo acetylcholine receptor causes an autoimmune response to receptors in rat muscle.

1978 • 140 citations

Antibodies from patients with myasthenia gravis recognize determinants unique to extrajunctional acetylcholine receptors.

1979 • 139 citations

Myasthenia Gravis

1978 • 134 citations

Acetylcholine receptors in normal and denervated rat diaphragm muscle. I. Purification and interaction with [¹²⁵I]-labeled α-bungarotoxin

1975 • 133 citations

Immunochemical studies on acetylcholine receptor from Torpedo californica

1977 • 130 citations

Strain differences in the autoimmune response of mice to acetylcholine receptors

1976 • 130 citations

Striated muscle fibres differentiate in monolayer cultures of adult thymus reticulum

1975 • 120 citations

Organization of ligand binding sites at the acetylcholine receptor: a study with monoclonal antibodies

1983 • 116 citations

MONOCLONAL AUTOANTIBODIES TO ACETYLCHOLINE RECEPTORS: EVIDENCE FOR A DOMINANT IDIORPE AND REQUIREMENT OF COMPLEMENT FOR PATHOGENICITY*

1981 • 116 citations

Monoclonal antibodies as probes of acetylcholine receptor structure. 1. Peptide mapping

1981 • 115 citations

Comparison of the subunits of Torpedo californica acetylcholine receptor by peptide mapping

1979 • 114 citations

END‐PLATE POTENTIALS IN EXPERIMENTAL AUTOIMMUNE MYASTHENIA GRAVIS IN RATS*

1976 • 114 citations

Immunological characterisation of the cholinergic receptor protein from Electrophorus electricus

1973 • 113 citations

Experimental autoimmune myasthenia induced in monkeys by purified acetylcholine receptor

1975 • 106 citations

ACETYLCHOLINE RECEPTORS AND END-PLATE ELECTROPHYSIOLOGY IN MYASTHENIA GRAVIS

1978 • 106 citations

Monoclonal anti-acetylcholine-receptor antibodies directed against the cholinergic binding site

1981 • 105 citations

End‐plate currents and acetylcholine noise at normal and myasthenic human end‐plates.

1979 • 104 citations

Molecular cloning of cDNA coding for the gamma subunit of Torpedo acetylcholine receptor.

1982 • 102 citations

Thymic lymphocytes bear a surface antigen which cross-reacts with acetylcholine receptor

1980 • 99 citations

Monoclonal antibodies against purified nicotinic acetylcholine receptor

1979 • 97 citations

Modulation of acetylcholine receptor in rat diaphragm by anti-receptor sera

1978 • 94 citations

Disulfide bond cross-linked dimer in acetylcholine receptor from Torpedo californica

1977 • 92 citations

STRUCTURE AND FUNCTION OF THE ACETYLCHOLINE RECEPTOR MOLECULE STUDIED USING MONOCLONAL ANTIBODIES

1981 • 90 citations

Subunit structure and peptide mapping of junctional and extrajunctional acetylcholine receptors from rat muscle

1979 • 90 citations

Immunological comparison of acetylcholine receptors and their subunits from species of electric ray

1977 • 89 citations

Studies of reversible and irreversible interactions of an alkylating agonist with Torpedo californica acetylcholine receptor in membrane-bound and purified states

1979 • 88 citations

Human myasthenic sera reduce acetylcholine sensitivity of human muscle cells in tissue culture

1977 • 87 citations

Subunit structure of the acetylcholine receptor from denervated rat skeletal muscle

1977 • 86 citations

Phosphorylation of membrane proteins at a cholinergic synapse.

1977 • 83 citations

The nicotinic cholinergic receptor protein: improved purification method, preliminary amino acid composition and observed auto‐immuno response

1974 • 82 citations

Monoclonal Antibodies to Neural Antigens

1982 • 78 citations

Antibody to acetylcholine receptor increases degradation of junctional and extrajunctional receptors in adult muscle

1978 • 78 citations

Neuromuscular transmission after immunization against acetylcholine receptors

1975 • 76 citations

Acetylcholine receptor subunits transit a precursor pool before acquiring alpha-bungarotoxin binding activity.

1981 • 76 citations

Induction of anti-idiotypic antibodies by immunisation with syngeneic spleen cells educated with acetylcholine receptor

1978 • 75 citations

Monoclonal antibodies directed against the neurotransmitter binding site of nicotinic acetylcholine receptor

1980 • 70 citations

Anti‐Idiotypic Antibodies against the Receptor Antibodies in Myasthenia Gravis

1981 • 64 citations

Monoclonal antibodies against defined determinants of acetylcholine receptor

1979 • 63 citations

Subunit composition of bovine muscle acetylcholine receptor

1982 • 61 citations

A monoclonal anti‐idiotypic antibody against anti‐receptor antibodies from myasthenic sera

1982 • 60 citations

Specific immunosuppression of experimental autoimmune myasthenia gravis by denatured acetylcholine receptor.

1978 • 60 citations

Biology of Myasthenia Gravis

1980 • 60 citations

Immunological relationship between acetylcholine receptor and thymus: a possible significance in myasthenia gravis.

1975 • 59 citations

Identification of a cDNA clone coding for the acetylcholine binding subunit of Torpedo marmorata acetylcholine receptor.

1982 • 56 citations

Change in state of phosphorylation of acetylcholine receptor during maturation of the electromotor synapse in Torpedo marmorata electric organ.

1981 • 56 citations

Plasmapheresis and the Immunobiology of Myasthenia Gravis

1980 • 55 citations

Affinity alkylation labels two subunits of the reduced acetylcholine receptor from mammalian muscle.

1977 • 52 citations

Immunological characterization of an irreversibly denatured acetylcholine receptor

1977 • 51 citations

Passive transfer of experimental autoimmune myasthenia by lymph node cells in inbred guinea pigs.

1975 • 51 citations

Localization of acetylcholine receptor in excitable membrane from the electric organ of Torpedo: Evidence for exposure of receptor antigenic sites on both sides of the membrane.

1978 • 49 citations

Acetylcholine-induced channels and transmitter release at human endplates

1978 • 49 citations

Experimental myasthenia in Balb/c mice immunized with rat acetylcholine receptor from rat denervated muscle.

1976 • 48 citations

Binding of antibodies to acetylcholine receptors in Electrophorus and Torpedo electroplax membranes.

1978 • 48 citations

Interaction of monoclonal antibodies to torpedo acetylcholine receptor with the receptor of skeletal muscle

1983 • 48 citations

Cholinergic sites in skeletal muscle. I. Denervation effects

1976 • 47 citations

Purification and biochemical characterization of nicotinic acetylcholine receptors of human muscle.

1982 • 47 citations

ANTIBODIES TO ACETYLCHOLINE RECEPTORS IN RABBITS: IMMUNOCHEMICAL AND ELECTROPHYSIOLOGICAL STUDIES*

1976 • 47 citations

Cell-Free Synthesis of Acetylcholine Receptor Polypeptides

1980 • 45 citations

In situ labeling of Torpedo and rat muscle acetylcholine receptor by a photoaffinity derivative of alpha-bungarotoxin.

1980 • 45 citations

Composition of acetylcholine receptor protein from skeletal muscle

1978 • 42 citations

Transmembrane orientation of an early biosynthetic form of acetylcholine receptor delta subunit determined by proteolytic dissection in conjunction with monoclonal antibodies

1983 • 42 citations

The developmental change in immunological properties of the acetylcholine receptor in rat muscle

1981 • 41 citations

EFFECTS OF NORMAL AND MYASTHENIC SERUM FACTORS ON INNERVATED AND CHRONICALLY DENERVATED MAMMALIAN MUSCLES

1976 • 39 citations

Monoclonal antibodies to neural antigens

1981 • 39 citations

Active acetylcholine receptor fragment obtained by tryptic digestion of acetylcholine receptor from Torpedo californica

1979 • 38 citations

Disorders of the motor unit

1982 • 38 citations

Immunological cross-reactivity between the α-bungarotoxin-binding component from rat brain and nicotinic acetylcholine receptor

1982 • 38 citations

Reduced muscle acetylcholine sensitivity in rats immunised with acetylcholine receptor

1976 • 37 citations

Myasthenia in frogs immunized against cholinergic-receptor protein

1979 • 36 citations

Preparation and immunochemical characterization of a water-soluble acetylcholine receptor fraction from the electric organ tissue of the electric eel

1975 • 35 citations

Properties of nicotinic acetylcholine receptors isolated by affinity chromatography on monoclonal antibodies.

1980 • 33 citations

Purification and Characterization of Nicotinic Acetylcholine Receptors from Muscle

1980 • 32 citations

Immunology of the Nicotinic Acetylcholine Receptor

1979 • 32 citations

Affinity labelling by bromoacetylcholine of a characteristic subunit in the acetylcholine receptor from muscle and Torpedo electric organ

1979 • 30 citations

ACETYLCHOLINE RECEPTOR: MOLECULAR DISSECTION AND MONOCLONAL ANTIBODIES IN THE STUDY OF EXPERIMENTAL MY ASTHENIA *

1981 • 28 citations

INTERACTION OF HUMAN ANTIBODY AND MURINE MONOCLONAL ANTIBODY WITH MUSCLE ACETYLCHOLINE RECEPTOR

1981 • 28 citations

Histological localization of binding sites of α-bungarotoxin and of antibodies specific to acetylcholine receptor in goldfish optic nerve and tectum

1980 • 28 citations

Presynaptic receptors: mechanism and function

1983 • 27 citations

Immunochemical properties of junctional and extrajunctional acetylcholine receptor

1981 • 25 citations

Monoclonal antibodies modify acetylcholine-induced ionic channel properties in cultured chick myoballs

1983 • 25 citations

Purification and Characterization of the Cholinergic Receptor Protein in its Membrane-Bound and Detergent-Soluble Forms from the Electric Organ of Torpedo marmorata

1977 • 24 citations

Ligand induced changes in stability and distribution of acetylcholine receptors on surface membranes of muscle cells

1979 • 24 citations

Structural similarities between acetylcholine receptors from fish electric organs and mammalian muscle

1982 • 23 citations

ACETYLCHOLINE RECEPTOR AND MYASTHENIA GRAVIS*

1976 • 22 citations

Properties of end‐plate channels in rats immunized against acetylcholine receptors

1981 • 22 citations

Cell surface receptors

1984 • 21 citations

Comparison of the subunit structure of acetylcholine receptors from muscle and electric organ of Electrophorus electricus

1983 • 20 citations

Acetylcholine Receptors in Vertebrate Skeletal Muscles and Electric Tissues

1973 • 20 citations

Differences in the interaction of acetylcholine receptor antibodies with receptor from normal, denervated and myasthenic human muscle.

1982 • 18 citations

Membrane transport and neuroreceptors

1982 • 18 citations

A CHOLINOCEPTOR ANTISERUM: ITS PHARMACOLOGICAL PROPERTIES

1976 • 17 citations

Monoclonal antibodies against the human acetylcholine receptor

1983 • 17 citations

Adipsia and aphagia elicited by intracerebroventricular injections of antiacetylcholine receptor antibodies

1980 • 17 citations

Inhibition of α‐bungarotoxin binding to acetylcholine receptors by antisera from animals with experimental autoimmune myasthenia gravis

1980 • 17 citations

Effects of antibodies to Torpedo acetylcholine receptor on the acetylcholine receptor-lonic channel complex of Torpedo electroplax and rabbit intercostal muscle

1979 • 17 citations

Neuromuscular transmission in experimental autoimmune myasthenia gravis (EAMG)

1981 • 15 citations

α‐Bungarotoxin binding to the nicotinic acetylcholine receptor is inhibited by two distinct subpopulations of anti‐receptor antibodies

1982 • 15 citations

Cytophilic Antibodies in Experimental Autoimmune Myasthenia Gravis

1977 • 15 citations

EFFECTS OF DRUGS AND ANTIBODIES ON THE POST-SYNAPTIC MEMBRANE OF THE NEUROMUSCULAR JUNCTION

1981 • 14 citations

Immune regulation of experimental myasthenia.

1980 • 14 citations

Fractionation of antibodies to acetylcholine receptor according to antigenic specificity

1979 • 14 citations

Immunosuppression of experimental autoimmune myasthenia gravis by azathioprine. II. Evaluation of immunological mechanism.

1977 • 13 citations

A new mechanism revealed for the action of antibodies on acetylcholine receptor function

1981 • 12 citations

ANTIBODIES TO THE NICOTINIC ACETYLCHOLINE RECEPTOR, OBTAINED FROM SERUM OF MYASTHENIC PATIENTS, MAY DECREASE ACETYLCHOLINE RELEASE FROM RAT HIPPOCAMPAL NERVE ENDINGS IN VITRO

1981 • 11 citations

Immunosuppression of Experimental Autoimmune Myasthenia Gravis by Azathioprine

1977 • 8 citations

Effect of azathioprine on the affinity of antibodies against acetylcholine receptor: Analysis with purified antibodies

1979 • 8 citations

Increase in the translatable mRNA for acetylcholine receptor during embryonic development of Torpedo ocellata electric organ

1982 • 7 citations

Antigenic similarities between the subunits of acetylcholine receptor from Torpedo marmorata

1982 • 7 citations

Modification of acetylcholine receptor: chemical and immunological characterization of polyalanyl acetylcholine receptor

1980 • 6 citations

An anti‐acetylcholine receptor monoclonal antibody cross‐reacts with phosvitin

1983 • 6 citations

IDENTIFICATION OF THE ACETYLCHOLINE RECEPTOR IN DIFFERENT MEMBRANE SPECIES

1981 • 2 citations