Microglia Exhibit Clonal Variability in Eliciting Cytotoxic T Lymphocyte Responses Independent of Class I Expression

Microglia: Intrinsic immuneffector cell of the brain

1995 • 1,099 citations

Functional plasticity of microglia: A review

1988 • 931 citations

Immunologically Privileged Sites

1978 • 815 citations

Evidence that a Single Peptide–MHC Complex on a Target Cell Can Elicit a Cytolytic T Cell Response

1996 • 684 citations

Immunology Taught by Viruses

1996 • 656 citations

Normal adult ramified microglia separated from other central nervous system macrophages by flow cytometric sorting. Phenotypic differences defined and direct ex vivo antigen presentation to myelin basic protein-reactive CD4+ T cells compared.

1995 • 622 citations

ANTIGEN PROCESSING AND PRESENTATION BY THE CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX

1996 • 613 citations

Cytotoxic T-cell activity antagonized by naturally occurring HIV-1 Gag variants

1994 • 418 citations

Cellular reservoirs of HIV-1 in the central nervous system of infected individuals

1996 • 412 citations

Localization of HIV‐1 in human brain using polymerase chain reaction/in situ hybridization and immunocytochemistry

1996 • 405 citations

Colony-stimulating factor-1 receptor

1990 • 362 citations

Mature microglia resemble immature antigen-presenting cells

1998 • 339 citations

Viral Persistence in Neurons Explained by Lack of Major Histocompatibility Class I Expression

1991 • 308 citations

Efficient processing of an antigenic sequence for presentation by MHC class I molecules depends on its neighboring residues in the protein

1991 • 303 citations

A revised view of the central nervous system microenvironment and major histocompatibility complex class II antigen presentation

1998 • 276 citations

Microglia induce CD4 T lymphocyte final effector function and death.

1996 • 266 citations

Neuropathology of Early HIV‐1 Infection

1996 • 263 citations

The central nervous system as an immunocompetent organ: role of glial cells in antigen presentation.

1996 • 230 citations

IFN-gamma is required for viral clearance from central nervous system oligodendroglia.

1999 • 220 citations

IFN-γ Is Required for Viral Clearance from Central Nervous System Oligodendroglia

1999 • 197 citations

Impaired cytotoxic T lymphocyte recognition due to genetic variations in the main immunogenic region of the human immunodeficiency virus 1 NEF protein.

1994 • 175 citations

Inverted Immunodominance and Impaired Cytolytic Function of CD8+ T Cells During Viral Persistence in the Central Nervous System

1999 • 171 citations

Different roles for rcytotoxic T cells in the control of infections with cytopathic versus noncytopathic viruses

1996 • 171 citations

Antigen presentation in the central nervous system. The inhibitory effect of IL-10 on MHC class II expression and production of cytokines depends on the inducing signals and the type of cell analyzed.

1994 • 168 citations

Changing patterns of dominance in the CD8+ T cell response during acute and persistent murine γ-herpesvirus infection

1999 • 151 citations

TAP (transporter associated with antigen processing)-independent presentation of endogenously synthesized peptides is enhanced by endoplasmic reticulum insertion sequences located at the amino- but not carboxyl-terminus of the peptide.

1994 • 147 citations

Mouse hepatitis virus is cleared from the central nervous systems of mice lacking perforin-mediated cytolysis

1997 • 145 citations

Determination of the origin and nature of brain macrophages and microglial cells in mouse central nervous system, using non‐radioactive in situ hybridization and immunoperoxidase techniques

1992 • 122 citations

Mouse hepatitis virus-specific cytotoxic T lymphocytes protect from lethal infection without eliminating virus from the central nervous system

1995 • 119 citations

The generation of MHC class I-associated peptides is only partially inhibited by proteasome inhibitors: involvement of nonproteasomal cytosolic proteases in antigen processing?

1997 • 108 citations

Detection of a vigorous HIV-1-specific cytotoxic T lymphocyte response in cerebrospinal fluid from infected persons with AIDS dementia complex.

1992 • 107 citations

Flanking residues alter antigenicity and immunogenicity of multi-unit CTL epitopes.

1996 • 102 citations

Outcome of Kupffer cell antigen presentation to a cloned murine Th1 lymphocyte depends on the inducibility of nitric oxide synthase by IFN-gamma.

1994 • 94 citations

Microglia stimulate naive T-cell differentiation without stimulating T-cell proliferation

1999 • 92 citations

Mouse microglial cell lines differing in constitutive and interferon-γ-inducible antigen-presenting activities for naive and memory CD4+ and CD8+ T cells

1995 • 92 citations

Major Histocompatibility Complex Class I Viral Antigen Processing in the Secretory Pathway Defined by the trans-Golgi Network Protease Furin

1998 • 82 citations

Immune therapy of a persistent and disseminated viral infection

1987 • 77 citations

Murine hepatic accessory cells support the proliferation of Th1 but not Th2 helper T lymphocyte clones.

1989 • 71 citations

Characterization of the Ld-restricted cytotoxic T-lymphocyte epitope in the mouse hepatitis virus nucleocapsid protein

1993 • 63 citations

Human immunodeficiency virus infection in microglia: Correlation between cells infected in the brain and cells cultured from infectious brain tissue

1992 • 59 citations

Differential Presentation of the Same MHC Class I Epitopes by Fibroblasts and Dendritic Cells

1998 • 56 citations

Characterization of mouse hepatitis virus-specific cytotoxic T cells derived from the central nervous system of mice infected with the JHM strain

1993 • 54 citations

Biology of the mononuclear phagocyte system of the central nervous system and HIV infection

1994 • 48 citations

Mouse hepatitis virus nucleocapsid protein-specific cytotoxic T lymphocytes are Ld restricted and specific for the carboxy terminus

1992 • 43 citations

Microglial infection by a neurovirulent murine retrovirus results in defective processing of envelope protein and intracellular budding of virus particles

1994 • 39 citations

Cross-reactive lysis of human targets infected with prototypic and clinical human immunodeficiency virus type 1 (HIV-1) strains by murine anti-HIV-1 IIIB env-specific cytotoxic T lymphocytes

1993 • 32 citations

MHC class I-restricted processing of transmembrane proteins. Mechanism and biologic significance.

1995 • 30 citations

An endogenously synthesized decamer peptide efficiently primes cytotoxic T cells specific for the HIV‐1 envelope glycoprotein

1993 • 30 citations

A subset of mouse splenic macrophages can constitutively present alloantigen directly to CD8+ T cells.

1991 • 26 citations

Differential antigen presentation by cloned populations of mouse splenic macrophages.

1989 • 21 citations

Phenotypes and alloantigen-presenting activity of individual clones of microglia derived from the mouse brain

1992 • 16 citations

A Subset of Splenic Macrophages Process and Present Native Antigen to Naive Antigen-Specific CD4+T-Cells from Mice Transgenic for an αβ T-Cell Receptor

1995 • 15 citations

Mouse splenic macrophage cell lines with different antigen-presenting activities for CD4+ helper T cell subsets and allogeneic CD8+ T cells

1992 • 15 citations

A mechanism of restricted human immunodeficiency virus type 1 expression in human glial cells

1996 • 15 citations

Alloantigen presentation by individual clones of mouse splenic macrophages. Selective expression of IL-1 alpha in response to CD8+ T cell-derived IFN-gamma defines the alloantigen-presenting phenotype.

1993 • 12 citations

Constitutive antigen presentation by mouse splenic macrophages is restricted to the progeny of a distinct progenitor population

1991 • 8 citations

Heterogeneity of Mouse Brain Macrophages in Alloantigen Presentation to Naive CD8+ T Cells as Revealed by a Panel of Microglial Cell Lines

1996 • 6 citations