Mouse hepatitis virus-specific cytotoxic T lymphocytes protect from lethal infection without eliminating virus from the central nervous system

Surface expression of alpha 4 integrin by CD4 T cells is required for their entry into brain parenchyma.

1993 • 837 citations

Inducible expression of H–2 and Ia antigens on brain cells

1984 • 656 citations

Inflammatory cytokines within the central nervous system: sources, function, and mechanism of action

1992 • 614 citations

Pathogenesis of Demyelination Induced by a Mouse Hepatitis

1973 • 340 citations

Viral Persistence in Neurons Explained by Lack of Major Histocompatibility Class I Expression

1991 • 308 citations

Mechanism of demyelination in JHM virus encephalomyelitis

1973 • 253 citations

Cytoimitiunotherapy for persistent virus infection reveals a unique clearance pattern from the central nervous system

1986 • 250 citations

Detection of coronavirus RNA and antigen in multiple sclerosis brain

1992 • 210 citations

Murine hepatitis virus-4 (strain JHM)-induced neurologic disease is modulated in Vivo by monoclonal antibody

1984 • 206 citations

Effective clearance of mouse hepatitis virus from the central nervous system requires both CD4+ and CD8+ T cells

1990 • 189 citations

Human coronavirus gene expression in the brains of multiple sclerosis patients

1992 • 188 citations

Helper-cytotoxic T lymphocyte (CTL) determinant linkage required for priming of anti-HIV CD8+ CTL in vivo with peptide vaccine constructs.

1994 • 181 citations

Demyelination induced by murine hepatitis virus JHM strain (MHV-4) is immunologically mediated

1990 • 165 citations

Chronic central nervous system demyelination in mice after JHM virus infection

1981 • 158 citations

Molecular bases of the immune response to neural antigens

1987 • 156 citations

Subacute sclerosing panencephalitis. Current status.

1985 • 155 citations

Modulation of blood-brain barrier permeability by tumor necrosis factor and antibody to tumor necrosis factor in the rat.

1992 • 151 citations

Purified Influenza Virus Nucleoprotein Protects Mice from Lethal Infection

1987 • 149 citations

Protective effect of monoclonal antibodies on lethal mouse hepatitis virus infection in mice

1986 • 128 citations

The cellular and molecular pathogenesis of coronaviruses.

1993 • 124 citations

Anti‐viral protection and prevention of lymphocytic choriomeningitis or of the local footpad swelling reaction in mice by immunization with vaccinia‐recombinant virus expressing LCMV‐WE nucleoprotein or glycoprotein

1989 • 123 citations

CTL access to tissue antigen is restricted in vivo.

1994 • 120 citations

Monoclonal antibodies to the matrix (El) glycoprotein of mouse hepatitis virus protect mice from encephalitis

1989 • 113 citations

T-cell-mediated clearance of mouse hepatitis virus strain JHM from the central nervous system

1989 • 101 citations

Coronavirus infects and causes demyelination in primate central nervous system

1992 • 100 citations

The antiviral activity of immune CD8+ T cells is dependent on interferon-gamma.

1991 • 98 citations

T cell-dependent IFN-gamma exerts an antiviral effect in the central nervous system but not in peripheral solid organs.

1993 • 88 citations

Murine Coronaviruses: Isolation and Characterization of Two Plaque Morphology Variants of the JHM Neurotropic Strain

1982 • 88 citations

In vivo effects of coronavirus-specific T cell clones: DTH inducer cells prevent a lethal infection but do not inhibit virus replication.

1986 • 86 citations

Characterization of brain-infiltrating mononuclear cells during infection with mouse hepatitis virus strain JHM

1991 • 83 citations

Primary structure of the membrane and nucleocapsid protein genes of feline infectious peritonitis virus and immunogenicity of recombinant vaccinia viruses in kittens

1991 • 80 citations

Production of mice from a lethal coronavirus infection in the central nervous system by adoptive transfer of virus-specific T cell clones

1991 • 77 citations

Nucleocapsid or spike protein-specific CD4+ T lymphocytes protect against coronavirus-induced encephalomyelitis in the absence of CD8+ T cells.

1991 • 76 citations

Protection from mouse hepatitis virus type 3-induced acute disease by an anti-nucleoprotein monoclonal antibody

1987 • 68 citations

Immune response gene products (Ia antigens) on glial and endothelial cells in virus-induced demyelination.

1987 • 67 citations

ICAM‐1‐independent lymphocyte transmigration across high endothelium : Differential up‐regulation by interferon γ, tumor necrosis factor‐α and interleukin 1β

1992 • 66 citations

Characterization of the Ld-restricted cytotoxic T-lymphocyte epitope in the mouse hepatitis virus nucleocapsid protein

1993 • 63 citations

Pathogenesis of Virus-Induced Demyelination

1993 • 57 citations

Mouse hepatitis virus spike and nucleocapsid proteins expressed by adenovirus vectors protect mice against a lethal infection

1993 • 55 citations

The astrocyte is a target cell in mice persistently infected with mouse hepatitis virus, strain JHM

1987 • 55 citations

Characterization of mouse hepatitis virus-specific cytotoxic T cells derived from the central nervous system of mice infected with the JHM strain

1993 • 54 citations

Efficacy of individual measles virus structural proteins in the protection of rats from measles encephalitis

1991 • 52 citations

Characterization and Immunological Properties of Influenza A Virus Nucleoprotein (NP): Cell-associated NP Isolated from Infected Cells or Viral NP Expressed by Vaccinia Recombinant Virus do not Confer Protection

1990 • 51 citations

The role of gamma interferon in infection of susceptible mice with murine coronavirus, MHV-JHM

1991 • 44 citations

Mouse hepatitis virus nucleocapsid protein-specific cytotoxic T lymphocytes are Ld restricted and specific for the carboxy terminus

1992 • 43 citations

In the presence of dexamethasone, gamma interferon induces rat oligodendrocytes to express major histocompatibility complex class II molecules.

1992 • 42 citations

Differential effects of flanking residues on presentation of epitopes from chimeric peptides

1994 • 40 citations

Differential expression of H-2K and H-2D in the central nervous system of mice infected with Theiler's virus.

1993 • 38 citations

Population dynamics of lymphocyte subsets in the central nervous system of rats with different susceptibility to coronavirus-induced demyelinating encephalitis.

1991 • 37 citations

Coronavirus induced primary demyelination: indications for the involvement of a humoral immune response

1991 • 31 citations

Location of Antibody Epitopes within the Mouse Hepatitis Virus Nucleocapsid Protein

1994 • 30 citations

Modulation of cellular macromolecular synthesis by coronavirus: implication for pathogenesis

1994 • 29 citations

An immunodominant CD4+ T cell site on the nucleocapsid protein of murine coronavirus contributes to protection against encephalomyelitis

1993 • 28 citations

Experimental Neuropathology of Chronic Demyelination Induced by a JHM Virus Variant (DS)

1987 • 28 citations

In vivo and in vitro models of demyelinating disease. XVII. The infectious process in athymic rats inoculated with JHM virus

1987 • 24 citations

Natural killer cell activity during mouse hepatitis virus infection: Response in the absence of interferon

1983 • 23 citations

Induction of protective immunity against coronavirus‐induced encephalomyelitis: Evidence for an important role of CD8⁺ T cells in vivo

1993 • 22 citations

[Histopathology and pathogenesis of experimental JHM-virus encephalomyelitis in apes].

1956 • 20 citations

Cytotoxic T cell repertoire selection. A single amino acid determines alternative class I restriction.

1994 • 19 citations

Studies on the mechanism of protection from acute viral encephalomyelitis by delayed-type hypersensitivity inducer T cell clones

1989 • 18 citations

Relapsing encephalomyelitis following transfer of partial immunity to JHM virus

1990 • 8 citations