Inflammatory changes are tightly associated with neurodegeneration in the brain and spinal cord of the APP/PS1KI mouse model of Alzheimer's disease

Relative expression software tool (REST(C)) for group-wise comparison and statistical analysis of relative expression results in real-time PCR

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Reactive microglia are positive for HLA‐DR in the substantia nigra of Parkinson's and Alzheimer's disease brains

1988 • 2,754 citations

Microglia Initiate Central Nervous System Innate and Adaptive Immune Responses through Multiple TLRs

2004 • 1,156 citations

Axonopathy and Transport Deficits Early in the Pathogenesis of Alzheimer's Disease

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The Pathogenesis of Senile Plaques

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Expression of immune system-associated antigens by cells of the human central nervous system: Relationship to the pathology of Alzheimer's disease

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Osteopontin

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Microglial response to amyloid plaques in APPsw transgenic mice.

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TGF-β1 promotes microglial amyloid-β clearance and reduces plaque burden in transgenic mice

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Interleukin-1 Expression in Different Plaque Types in Alzheimerʼs Disease

1995 • 538 citations

Role of the Toll-Like Receptor 4 in Neuroinflammation in Alzheimer’s Disease

2007 • 485 citations

Role of toll-like receptor signalling in A uptake and clearance

2006 • 462 citations

Massive CA1/2 Neuronal Loss with Intraneuronal and N-Terminal Truncated Aβ42 Accumulation in a Novel Alzheimer Transgenic Model

2004 • 396 citations

Association of Microglia with Amyloid Plaques in Brains of APP23 Transgenic Mice

1999 • 332 citations

Evidence for glial-mediated inflammation in aged APPSW transgenic mice

1999 • 295 citations

Focal glial activation coincides with increased BACE1 activation and precedes amyloid plaque deposition in APP[V717I] transgenic mice

2005 • 287 citations

β-Amyloid-induced glial expression of both pro- and anti-inflammatory cytokines in cerebral cortex of aged transgenic Tg2576 mice with Alzheimer plaque pathology

2001 • 278 citations

The significance of neuroinflammation in understanding Alzheimer’s disease

2006 • 258 citations

Time Course of the Development of Alzheimer-like Pathology in the Doubly Transgenic PS1+APP Mouse

2002 • 245 citations

Screening of innate immune receptors in neurodegenerative diseases: A similar pattern

2007 • 215 citations

Activation of Toll-like Receptor 2 on Microglia Promotes Cell Uptake of Alzheimer Disease-associated Amyloid β Peptide

2005 • 208 citations

Aβ-Induced Inflammatory Processes in Microglia Cells of APP23 Transgenic Mice

2001 • 199 citations

Induction of cytokines in glial cells surrounding cortical β‐amyloid plaques in transgenic Tg2576 mice with Alzheimer pathology

2000 • 198 citations

PS2APP Transgenic Mice, Coexpressing hPS2mut and hAPPswe, Show Age-Related Cognitive Deficits Associated with Discrete Brain Amyloid Deposition and Inflammation

2003 • 187 citations

Neurodegeneration in the Niemann–Pick C mouse: glial involvement

2002 • 169 citations

Toll‐like receptors 2 and 4 mediate Aβ(1–42) activation of the innate immune response in a human monocytic cell line

2007 • 165 citations

Molecular pathophysiology in Tay-Sachs and Sandhoff diseases as revealed by gene expression profiling

2002 • 160 citations

Transplanted astrocytes internalize deposited β‐amyloid peptides in a transgenic mouse model of Alzheimer's disease

2007 • 155 citations

Microglial Activation is Required for Aβ Clearance After Intracranial Injection of Lipopolysaccharide in APP Transgenic Mice

2007 • 134 citations

Axonopathy in an APP/PS1 transgenic mouse model of Alzheimer’s disease

2006 • 128 citations

Age-dependent axonal degeneration in an Alzheimer mouse model

2006 • 123 citations

Intraneuronal APP/Aβ Trafficking and Plaque Formation in β‐Amyloid Precursor Protein and Presenilin‐1 Transgenic Mice

2002 • 119 citations

Circulating monocytic cells infiltrate layers of anterograde axonal degeneration where they transform into microglia

2005 • 115 citations

Neuroinflammation‐induced acceleration of amyloid deposition in the APP^V717F transgenic mouse

2001 • 113 citations

Astrocyte‐associated axonal damage in pre‐onset stages of experimental autoimmune encephalomyelitis

2005 • 107 citations

Deficits in working memory and motor performance in the APP/PS1ki mouse model for Alzheimer's disease

2007 • 92 citations

Osteopontin-Deficient Mice Exhibit Less Inflammation, Greater Tissue Damage, and Impaired Locomotor Recovery from Spinal Cord Injury Compared with Wild-Type Controls

2007 • 90 citations

Zinc and Inflammatory/Immune Response in Aging

2007 • 84 citations

Astrocytic calcium/zinc binding protein S100A6 over expression in Alzheimer's disease and in PS1/APP transgenic mice models

2004 • 75 citations

Molecular insights of the injured lesions of rat spinal cords: Inflammation, apoptosis, and cell survival

2006 • 62 citations

Metallothionein-I and -III expression in animal models of Alzheimer disease

2006 • 59 citations

Neurotoxicity of microglial cathepsin D revealed by secretome analysis

2007 • 59 citations

Expression of Metallothionein-I, -II, and -III in Alzheimer Disease and Animal Models of Neuroinflammation

2006 • 56 citations

Distribution of tryptase-containing mast cells and metallothionein reactive astrocytes in human brains with amyloid deposits

2007 • 40 citations

Alzheimer's disease-like neuropathology of gene-targeted APP-SLxPS1mut mice expressing the amyloid precursor protein at endogenous levels

2005 • 39 citations

S100A6, a calcium- and zinc-binding protein, is overexpressed in SOD1 mutant mice, a model for amyotrophic lateral sclerosis

2000 • 39 citations