Microglial Activation is Required for Aβ Clearance After Intracranial Injection of Lipopolysaccharide in APP Transgenic Mice
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References (37)
Amyloid Oligomers Exacerbate Tau Pathology in a Mouse Model of Tauopathy
2012 • 10,051 citations
The Pharmacological Basis of Therapeutics
1976 • 8,675 citations
Inflammation and Alzheimer's disease
2000 • 4,315 citations
Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse
1999 • 3,112 citations
Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes
1998 • 1,336 citations
Signal transduction by the lipopolysaccharide receptor, Toll‐like receptor‐4
2004 • 1,186 citations
Effects of Rofecoxib or Naproxen vs Placebo on Alzheimer Disease Progression
2003 • 955 citations
Ibuprofen Suppresses Plaque Pathology and Inflammation in a Mouse Model for Alzheimer's Disease
2000 • 880 citations
Glucocorticoids Increase Amyloid-β and Tau Pathology in a Mouse Model of Alzheimer’s Disease
2006 • 573 citations
A randomized controlled trial of prednisone in Alzheimer’s disease
2000 • 452 citations
Microglial Phagocytosis of Fibrillar β-Amyloid through a β1Integrin-Dependent Mechanism
2004 • 416 citations
Rofecoxib
2004 • 390 citations
Lipopolysaccharide-induced-neuroinflammation increases intracellular accumulation of amyloid precursor protein and amyloid β peptide in APPswe transgenic mice
2003 • 367 citations
Microglial Activation and β-Amyloid Deposit Reduction Caused by a Nitric Oxide-Releasing Nonsteroidal Anti-Inflammatory Drug in Amyloid Precursor Protein Plus Presenilin-1 Transgenic Mice
2002 • 344 citations
Scavenger receptors in neurobiology and neuropathology: Their role on microglia and other cells of the nervous system
2002 • 344 citations
Bone-marrow-derived cells contribute to the recruitment of microglial cells in response to β-amyloid deposition in APP/PS1 double transgenic Alzheimer mice
2004 • 286 citations
Intracranially administered anti-Abeta antibodies reduce beta-amyloid deposition by mechanisms both independent of and associated with microglial activation.
2003 • 263 citations
INFLAMMATION AND ALZHEIMERS DISEASE
2000 • 260 citations
Glucocorticoid- and mineralocorticoid receptors in microglial cells: The two receptors mediate differential effects of corticosteroids
1997 • 218 citations
Intrahippocampal LPS injections reduce Aβ load in APP+PS1 transgenic mice
2001 • 217 citations
Intracranially Administered Anti-Αβ Antibodies Reduce β-Amyloid Deposition by Mechanisms Both Independent of and Associated with Microglial Activation
2003 • 217 citations
Glucocorticoids Play a Fundamental Role in Protecting the Brain during Innate Immune Response
2003 • 191 citations
Microglial activation facilitates Aβ plaque removal following intracranial anti-Aβ antibody administration
2003 • 185 citations
Dynamic Complexity of the Microglial Activation Response in Transgenic Models of Amyloid Deposition: Implications for Alzheimer Therapeutics
2005 • 176 citations
Endogenous brain cytokine mRNA and inflammatory responses to lipopolysaccharide are elevated in the Tg2576 transgenic mouse model of Alzheimer’s disease
2001 • 172 citations
Scavenging of Alzheimer's amyloid ?-protein by microglia in culture
1996 • 160 citations
Inflammation and primary demyelination induced by the intraspinal injection of lipopolysaccharide
2005 • 157 citations
Time-dependent reduction in Aβ levels after intracranial LPS administration in APP transgenic mice
2004 • 145 citations
Complement Component C1q Modulates the Phagocytosis of Aβ by Microglia
2000 • 128 citations
Diverse microglial responses after intrahippocampal administration of lipopolysaccharide
2005 • 116 citations
Neuroinflammation‐induced acceleration of amyloid deposition in the APPV717F transgenic mouse
2001 • 113 citations
Exaggerated astrocyte reactivity after nigrostriatal deafferentation in the aged rat
1997 • 111 citations
Inflammation and cerebral amyloidosis are disconnected in an animal model of Alzheimer's disease
2003 • 99 citations
Dexamethasone inhibits the antigen presentation of dendritic cells in MHC class II pathway
2001 • 97 citations
IL-10 and glucocorticoids inhibit Aβ(1–42)- and lipopolysaccharide-induced pro-inflammatory cytokine and chemokine induction in the central nervous system
2003 • 59 citations
Dexamethasone selectively suppresses microglial trophic responses to hippocampal deafferentation
1999 • 44 citations
Regulation of pinocytosis in murine macrophages by colony-stimulating factors and other agents
1992 • 28 citations