Osteopontin-Deficient Mice Exhibit Less Inflammation, Greater Tissue Damage, and Impaired Locomotor Recovery from Spinal Cord Injury Compared with Wild-Type Controls

Osteopontin as a means to cope with environmental insults: regulation of inflammation, tissue remodeling, and cell survival

2001 • 1,048 citations

THE INFLUENCE OF THE PROINFLAMMATORY CYTOKINE, OSTEOPONTIN, ON AUTOIMMUNE DEMYELINATING DISEASE

2002 • 729 citations

Matrix Metalloproteinases Limit Functional Recovery after Spinal Cord Injury by Modulation of Early Vascular Events

2002 • 477 citations

Mice Lacking Osteopontin Show Normal Development and Bone Structure but Display Altered Osteoclast Formation In Vitro

1998 • 426 citations

Role of osteopontin in tumour progression

2004 • 411 citations

Endogenous Repair after Spinal Cord Contusion Injuries in the Rat

1997 • 398 citations

Evidence for a role of osteopontin in macrophage infiltration in response to pathological stimuli in vivo.

1998 • 368 citations

The effects of methylprednisolone and the ganglioside GM1 on acute spinal cord injury in rats

1994 • 330 citations

Axonal Regeneration and Lack of Astrocytic Gliosis in EphA4-Deficient Mice

2004 • 308 citations

Obstructive uropathy in the mouse: Role of osteopontin in interstitial fibrosis and apoptosis

1999 • 286 citations

Chapter 17 Spinal cord contusion models

2002 • 273 citations

Blockade of interleukin‐6 receptor suppresses reactive astrogliosis and ameliorates functional recovery in experimental spinal cord injury

2004 • 253 citations

Osteopontin deficiency protects joints against destruction in anti-type II collagen antibody-induced arthritis in mice

2002 • 205 citations

Effects of pro-inflammatory cytokines in experimental spinal cord injury

1997 • 201 citations

Cutting Edge: Attenuated Experimental Autoimmune Encephalomyelitis in Eta-1/Osteopontin-Deficient Mice

2002 • 173 citations

Voluntary Wheel Running Improves Recovery from a Moderate Spinal Cord Injury

2005 • 168 citations

Osteopontin and its Integrin Receptor α _v β ₃ Are Upregulated During Formation of the Glial Scar After Focal Stroke

1998 • 167 citations

Osteopontin functionally activates dendritic cells and induces their differentiation toward a Th1-polarizing phenotype

2005 • 166 citations

Reduced postischemic macrophage infiltration and interstitial fibrosis in osteopontin knockout mice

2003 • 152 citations

Osteopontin is upregulated during in vivo demyelination and remyelination and enhances myelin formation in vitro

2004 • 149 citations

A Mouse Model of Graded Contusive Spinal Cord Injury

1998 • 132 citations

Effects of limb exercise after spinal cord injury on motor neuron dendrite structure

2004 • 124 citations

The Macrophage in Acute Neural Injury: Changes in Cell Numbers Over time and Levels of Cytokine Production in Mammalian Central and Peripheral Nervous Systems

2000 • 122 citations

Spinal Cord Sodium, Potassium, Calcium, and Water Concentration Changes in Rats After Graded Contusion Injury

1989 • 114 citations

Soluble osteopontin inhibits apoptosis of adherent endothelial cells deprived of growth factors*

2002 • 109 citations

FAS deficiency reduces apoptosis, spares axons and improves function after spinal cord injury

2005 • 108 citations

Potent pro-inflammatory actions of leukemia inhibitory factor in the spinal cord of the adult mouse

2004 • 106 citations

Expression of osteopontin messenger RNA and protein in rheumatoid arthritis: Effects of osteopontin on the release of collagenase 1 from articular chondrocytes and synovial fibroblasts

2000 • 100 citations

Differentiation, Maturation, and Survival of Dendritic Cells by Osteopontin Regulation

2005 • 98 citations

Abnormal Pulmonary Granuloma Formation in Osteopontin-deficient Mice

2001 • 88 citations

Osteopontin Expression Correlates with Clinical Outcome in Patients with Mycobacterial Infection

2000 • 81 citations

Inflammation-induced GDNF improves locomotor function after spinal cord injury

2005 • 79 citations

Neurotrophins in Cultured Cells from Periodontal Tissues

2003 • 69 citations

Spatially and temporally different expression of osteonectin and osteopontin in the infarct zone of experimentally induced myocardial infarction in rats

2003 • 65 citations

Increased cell death in osteopontin-deficient cardiac fibroblasts occurs by a caspase-3-independent pathway

2004 • 54 citations

Interleukin 1 regulates the expression of osteopontin mRNA by osteoblasts

1990 • 53 citations

Upregulation of Osteopontin Expression in Rat Spinal Cord Microglia after Traumatic Injury

2003 • 50 citations

Decreased Neural Damage after Spinal Cord Injury in tPA-Deficient Mice

2003 • 49 citations

The involvement of osteopontin and its receptors in multiple myeloma cell survival, migration and invasion in the murine 5T33MM model

2005 • 46 citations

Osteopontin Deficiency in Rat Vascular Smooth Muscle Cells is Associated with an Inability to Adhere to Collagen and Increased Apoptosis

2000 • 42 citations

Inhibition of tumour necrosis factor‐α by antisense targeting produces immunophenotypical and morphological changes in injury‐activated microglia and macrophages

2004 • 34 citations

Gene expression profiling of cathepsin D, metallothioneins-1 and -2, osteopontin, and tenascin-C in a mouse spinal cord injury model by cDNA microarray analysis

2004 • 33 citations

Osteopontin affects the persistence of -glucan-induced hepatic granuloma formation and tissue injury through two distinct mechanisms

2004 • 32 citations

Osteopontin, a macrophage‐derived matricellular glycoprotein, inhibits axon outgrowth

2004 • 32 citations