3B but which 3B? And that's just one of the questions: the heterogeneity of human 5-HT3 receptors

A review of central 5-HT receptors and their function

1999 • 3,121 citations

Primary Structure And Functional Expression of the 5HT ₃ Receptor, A Serotonin-gated Ion Channel

1991 • 976 citations

Molecular Structure and Function of the Glycine Receptor Chloride Channel

2004 • 744 citations

The 5-HT3B subunit is a major determinant of serotonin-receptor function

1999 • 555 citations

Neuronal Nicotinic Acetylcholine Receptors: Structural Revelations, Target Identifications, and Therapeutic Inspirations

2005 • 534 citations

Central neurocircuitry associated with emesis

2001 • 409 citations

Alternate Stoichiometries of α4β2 Nicotinic Acetylcholine Receptors

2003 • 406 citations

Neuronal Nicotinic Acetylcholine Receptors

1996 • 377 citations

Pharmacology and Physiology of Human Adrenergic Receptor polymorphisms

2003 • 322 citations

GABA-A receptor subtypes in the brain: a paradigm for CNS drug discovery?

2003 • 317 citations

The Pharmacological and Functional Characteristics of the Serotonin 5-HT3A Receptor Are Specifically Modified by a 5-HT3B Receptor Subunit

1999 • 278 citations

Genetic mechanisms that underlie epilepsy

2004 • 260 citations

Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E

2003 • 245 citations

The 5-HT₃receptor as a therapeutic target

2007 • 228 citations

5-HT₃Receptors Mediate Serotonergic Fast Synaptic Excitation of Neocortical Vasoactive Intestinal Peptide/Cholecystokinin Interneurons

2002 • 211 citations

5-HT3 Receptors

2006 • 206 citations

Ca²⁺Permeability of the (α4)₃(β2)₂Stoichiometry Greatly Exceeds That of (α4)₂(β2)₃Human Acetylcholine Receptors

2006 • 193 citations

Differential Composition of 5-Hydroxytryptamine₃Receptors Synthesized in the Rat CNS and Peripheral Nervous System

2002 • 177 citations

Variations in the 5-Hydroxytryptamine Type 3B Receptor Gene as Predictors of the Efficacy of Antiemetic Treatment in Cancer Patients

2003 • 157 citations

Effects of the Serotonin Type 2A, 3A and 3B Receptor and the Serotonin Transporter Genes on Paroxetine and Fluvoxamine Efficacy and Adverse Drug Reactions in Depressed Japanese Patients

2006 • 155 citations

Characterization of the Novel Human Serotonin Receptor Subunits 5-HT_3C,5-HT_3D, and 5-HT_3E

2007 • 145 citations

The properties of 5‐HT₃ receptors in clonal cell lines studied by patch‐clamp techniques

1989 • 129 citations

Association between the 5′ UTR variant C178T of the serotonin receptor gene HTR3A and bipolar affective disorder

2001 • 129 citations

Atomic force microscopy reveals the stoichiometry and subunit arrangement of 5-HT₃receptors

2005 • 107 citations

Functional properties of a cloned 5‐hydroxytryptamine ionotropic receptor subunit: comparison with native mouse receptors.

1994 • 101 citations

Evidence for Expression of Heteromeric Serotonin 5-HT3 Receptors in Rodents

2000 • 95 citations

Serotonin 5-HT3 receptors in the central nervous system

2006 • 95 citations

A Polymorphism in the Serotonin Receptor 3A (HTR3A) Gene and Its Association With Harm Avoidance in Women

2003 • 87 citations

Distinguishable Haplotype Blocks in the HTR3A and HTR3B Region in the Japanese Reveal Evidence of Association of HTR3B with Female Major Depression

2006 • 87 citations

A cluster of novel serotonin receptor 3-like genes on human chromosome 3

2003 • 86 citations

Expression and function of 5-HT₃receptors in the enteric neurons of mice lacking the serotonin transporter

2002 • 82 citations

A Variant C178T in the Regulatory Region of the Serotonin Receptor GeneHTR3AModulates Neural Activation in the Human Amygdala

2005 • 77 citations

Polymorphisms in the 5-Hydroxytryptamine 2A Receptor and CytochromeP4502D6 Genes Synergistically Predict Fluvoxamine-Induced Side Effects in Japanese Depressed Patients

2005 • 74 citations

High-frequency HTR3B variant associated with major depression dramatically augments the signaling of the human 5-HT _3AB receptor

2008 • 72 citations

Physiogenomic association of statin‐related myalgia to serotonin receptors

2007 • 71 citations

The effect of 5-hydroxytryptamine 3A and 3B receptor genes on nausea induced by paroxetine

2006 • 71 citations

Desperately seeking subunits: are native 5-HT3 receptors really homomeric complexes?

1998 • 65 citations

Functional polymorphisms in dopamine and serotonin pathway genes

2005 • 63 citations

Serotonin receptor gene HTR3A variants in schizophrenic and bipolar affective patients.

2001 • 61 citations

Modified 5-HT3A receptor function by co-expression of alternatively spliced human 5-HT3A receptor isoforms

2000 • 60 citations

Tissue-specific alternative promoters of the serotonin receptor gene HTR3B in human brain and intestine

2006 • 59 citations

Genetic polymorphisms in the 5-hydroxytryptamine type 3B receptor gene and paroxetine-induced nausea

2007 • 59 citations

Polymorphisms in the novel serotonin receptor subunit gene HTR3C show different risks for acute chemotherapy-induced vomiting after anthracycline chemotherapy

2008 • 57 citations

Promiscuous coassembly of serotonin 5-HT ₃ and nicotinic α4 receptor subunits into Ca ²⁺ -permeable ion channels

1998 • 56 citations

Investigation of the human serotonin receptor gene HTR3B in bipolar affective and schizophrenic patients

2004 • 53 citations

5-HT3 receptors in the CNS: 3B or not 3B?

2003 • 49 citations

Mutational analysis of serotonin receptor genes: HTR3A and HTR3B in fibromyalgia patients

2004 • 49 citations

The 5-HT 3 receptor as a therapeutic target

2007 • 48 citations

Phosphorylation controls conductance of 5-HT3 receptor ligand-gated ion channels.

1995 • 45 citations

Naturally occurring variations in the human 5-HT3A gene profoundly impact 5-HT3 receptor function and expression

2007 • 44 citations

Monoamine related functional gene variants and relationships to monoamine metabolite concentrations in CSF of healthy volunteers

2004 • 42 citations

Serotonin 5‐HT₃ receptors in rat CA1 hippocampal interneurons: functional and molecular characterization

2002 • 40 citations

Cloning and expression of ligand-gated ion-channel receptor L2 in central nervous system

2005 • 38 citations

Differentiation of NG108-15 cells alters channel conductance and desensitization kinetics of the 5-HT3 receptor

1991 • 35 citations

Identification of 5-HT3A and 5-HT3B receptor subunits in human hippocampus

2007 • 34 citations

Generation of a selective 5-HT3B subunit-recognising polyclonal antibody; identification of immunoreactive cells in rat hippocampus

2001 • 33 citations

Detection of human and rodent 5-HT3Breceptor subunits by anti-peptide polyclonal antibodies

2006 • 30 citations

Immunolabelling of the 5‐HT_3B receptor subunit in the central and peripheral nervous systems in rodents

2007 • 26 citations

Single channel properties of the 5-HT3 subtype of serotonin receptor in primary cultures of rodent hippocampus

1994 • 25 citations

Characterization of 5-HT<sub>3</sub> Receptor Mutations Identified in Schizophrenic Patients

2006 • 24 citations

Functional characterization of a -100_-102delAAG deletion-insertion polymorphism in the promoter region of the HTR3B gene

2008 • 23 citations

Do polymorphisms in the human 5-HT3 genes contribute to pathological phenotypes?

2006 • 12 citations