Association of SET domain and myotubularin-related proteins modulates growth control

PTEN , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer

1997 • 4,753 citations

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

1997 • 2,746 citations

Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

1997 • 2,063 citations

Combining evolutionary information and neural networks to predict protein secondary structure

1994 • 1,471 citations

MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo

1993 • 1,169 citations

Protein Tyrosine Phosphatases: A Diverse Family of Intracellular and Transmembrane Enzymes

1991 • 973 citations

Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias

1992 • 944 citations

Altered Hox expression and segmental identity in Mll-mutant mice

1995 • 871 citations

The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene

1992 • 850 citations

Development of “substrate-trapping” mutants to identify physiological substrates of protein tyrosine phosphatases

1997 • 774 citations

Crystal Structure of Human Protein Tyrosine Phosphatase 1B

1994 • 747 citations

A gene mutated in X–linked myotubular myopathy defines a new putative tyrosine phosphatase family conserved in yeast

1996 • 611 citations

The protein encoded by the Drosophila position-effect variegation suppressor gene Su(var)3-9 combines domains of antagonistic regulators of homeotic gene complexes.

1994 • 560 citations

CDC25 Phosphatases as Potential Human Oncogenes

1995 • 498 citations

Evidence for protein-tyrosine-phosphatase catalysis proceeding via a cysteine-phosphate intermediate.

1991 • 468 citations

Dosage-dependent modifiers of polycomb and antennapedia mutations in Drosophila.

1988 • 460 citations

Immortalization and leukemic transformation of a myelomonocytic precursor by retrovirally transduced HRX-ENL

1997 • 416 citations

Imprinting a determined state into the chromatin of Drosophila

1990 • 391 citations

THE POLYCOMB AND TRITHORAX GROUP PROTEINS OF DROSOPHILA: Trans-Regulators of Homeotic Gene Function

1995 • 390 citations

Crystal Structure of the Dual Specificity Protein Phosphatase VHR

1996 • 340 citations

Form and Function in Protein Dephosphorylation

1996 • 334 citations

Control of MAP kinase activation by the mitogen-induced threonine/tyrosine phosphatase PAC1

1994 • 331 citations

Related chromosome binding sites for zeste, suppressors of zeste and Polycomb group proteins in Drosophila and their dependence on Enhancer of zeste function.

1993 • 319 citations

A family of receptor-linked protein tyrosine phosphatases in humans and Drosophila.

1989 • 303 citations

PAC-1: a Mitogen-Induced Nuclear Protein Tyrosine Phosphatase

1993 • 289 citations

Mammalian homologues of the Polycomb-group gene Enhancer of zeste mediate gene silencing in Drosophila heterochromatin and at S.cerevisiae telomeres

1997 • 277 citations

Visualization of intermediate and transition-state structures in protein-tyrosine phosphatase catalysis.

1996 • 271 citations

Identification of p130^cas as a Substrate for the Cytosolic Protein Tyrosine Phosphatase PTP-PEST

1996 • 263 citations

SET1, A Yeast Member of theTrithoraxFamily, Functions in Transcriptional Silencing and Diverse Cellular Processes

1997 • 238 citations

The Oncogenic Capacity of HRX-ENL Requires the Transcriptional Transactivation Activity of ENL and the DNA Binding Motifs of HRX

1998 • 238 citations

The Drosophila Polycomb-group gene Enhancer of zeste contains a region with sequence similarity to trithorax.

1993 • 235 citations

PcG complexes and chromatin silencing

1997 • 218 citations

Tyrosine phosphorylation of mammalian RNA polymerase II carboxyl-terminal domain.

1993 • 206 citations

Protein tyrosine phosphatases in signaling

1996 • 170 citations

The Drosophila trithorax proteins contain a novel variant of the nuclear receptor type DNA binding domain and an ancient conserved motif found in other chromosomal proteins

1995 • 148 citations

The Drosophila ash1 Gene Product, Which Is Localized at Specific Sites on Polytene Chromosomes, Contains a SET Domain and a PHD Finger

1996 • 126 citations

A Single Mutation Converts a Novel Phosphotyrosine Binding Domain into a Dual-specificity Phosphatase

1995 • 121 citations

The catalytic role of Cys124 in the dual specificity phosphatase VHR.

1994 • 119 citations

The Drosophila trithorax protein binds to specific chromosomal sites and is co-localized with Polycomb at many sites.

1995 • 118 citations

The HRX Proto-oncogene Product Is Widely Expressed in Human Tissues and Localizes to Nuclear Structures

1997 • 78 citations

Disruption of a Homolog of Trithorax by 11q23 Translocations: Leukemogenic and Transcriptional Implications

1997 • 53 citations