Stress-Inducible Regulation of Heat Shock Factor 1 by the Deacetylase SIRT1

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

2003 • 3,673 citations

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

2000 • 3,355 citations

Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase

2004 • 3,100 citations

hSIR2SIRT1 Functions as an NAD-Dependent p53 Deacetylase

2001 • 2,550 citations

Modulation of NF-κB-dependent transcription and cell survival by the SIRT1 deacetylase

2004 • 2,531 citations

Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A.

1990 • 1,835 citations

Regulation of Aging and Age-Related Disease by DAF-16 and Heat-Shock Factor

2003 • 1,431 citations

Invited Review: Heat shock proteins: modifying factors in physiological stress responses and acquired thermotolerance

2002 • 1,387 citations

Inhibition of Silencing and Accelerated Aging by Nicotinamide, a Putative Negative Regulator of Yeast Sir2 and Human SIRT1

2002 • 971 citations

Activation of heat shock gene transcription by heat shock factor 1 involves oligomerization, acquisition of DNA-binding activity, and nuclear localization and can occur in the absence of stress.

1993 • 879 citations

Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence

2002 • 842 citations

Regulation of Longevity inCaenorhabditis elegansby Heat Shock Factor and Molecular Chaperones

2003 • 697 citations

Molecularchaperones as HSF1-specific transcriptional repressors

1998 • 623 citations

Targeted Disruption of Heat Shock Transcription Factor 1 Abolishes Thermotolerance and Protection against Heat-inducible Apoptosis

1998 • 517 citations

Sirtuins: The ‘magnificent seven’, function, metabolism and longevity

2007 • 401 citations

Repression of the Heat Shock Factor 1 Transcriptional Activation Domain Is Modulated by Constitutive Phosphorylation

1997 • 316 citations

Heat Shock Factor 1 as a Coordinator of Stress and Developmental Pathways

2007 • 179 citations

A new use for the 'wing' of the 'winged' helix-turn-helix motif in the HSF-DNA cocrystal.

1999 • 170 citations

Interaction between heat shock factor and hsp70 is insufficient to suppress induction of DNA-binding activity in vivo.

1994 • 151 citations

In vivo binding of active heat shock transcription factor 1 to human chromosome 9 heterochromatin during stress

2002 • 147 citations

Inhibition of DNA Binding by Differential Sumoylation of Heat Shock Factors

2006 • 115 citations

Mutational analysis of the DNA-binding domain of yeast heat shock transcription factor

1994 • 33 citations

Genetic Identification of the Site of DNA Contact in the Yeast Heat Shock Transcription Factor

1995 • 26 citations