The Shaping of the Brain–Specific T Lymphocyte Repertoire in the Thymus

The S100 protein family: History, function, and expression

1995 • 930 citations

The rapid isolation of clonable antigen‐specific T lymphocyte lines capable of mediating autoimmune encephalomyelitis

1981 • 917 citations

T-cell recognition of an immuno-dominant myelin basic protein epitope in multiple sclerosis

1990 • 906 citations

Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity

1993 • 688 citations

Positive Selection of Thymocytes

1995 • 604 citations

The thymus selects the useful, neglects the useless and destroys the harmful

1989 • 378 citations

The cognitive paradigm and the immunological homunculus

1992 • 375 citations

Myelin basic protein‐specific T lymphocyte lines from MS patients and healthy individuals

1990 • 332 citations

Both rat and mouse T cell receptors specific for the encephalitogenic determinant of myelin basic protein use similar V alpha and V beta chain genes even though the major histocompatibility complex and encephalitogenic determinants being recognized are different.

1989 • 321 citations

Myelin autoreactivity in multiple sclerosis: recognition of myelin basic protein in the context of HLA-DR2 products by T lymphocytes of multiple-sclerosis patients and healthy donors.

1990 • 307 citations

Animal models

1994 • 276 citations

Autoaggressive T lymphocyte lines recognizing the encephalitogenic region of myelin basic protein: in vitro selection from unprimed rat T lymphocyte populations.

1985 • 196 citations

The human myelin basic protein gene is included within a 179-kilobase transcription unit: expression in the immune and central nervous systems.

1993 • 194 citations

Experimental autoimmune panencephalitis and uveoretinitis transferred to the Lewis rat by T lymphocytes specific for the S100 beta molecule, a calcium binding protein of astroglia.

1994 • 186 citations

T cell receptor β chain usage in myelin basic protein‐specific rat T lymphocytes

1989 • 162 citations

An unusual lineage of alpha/beta T cells that contains autoreactive cells.

1991 • 152 citations

Analysis of T cell receptor beta chains in Lewis rats with experimental allergic encephalomyelitis: conserved complementarity determining region 3.

1991 • 127 citations

Junctional sequences of fetal T cell receptor beta chains have few N regions.

1991 • 117 citations

A special repertoire of alpha:beta T cells in neonatal mice.

1991 • 108 citations

Protection from experimental allergic encephalomyelitis conferred by a monoclonal antibody directed against a shared idiotype on rat T cell receptors specific for myelin basic protein.

1988 • 104 citations

Identification of an embryonic isoform of myelin basic protein that is expressed widely in the mouse embryo.

1993 • 104 citations

Acetylcholine receptor‐reactive T lymphocytes from healthy subjects and myasthenia gravis patients

1991 • 92 citations

Clonal deletion of V beta 5+ T cells by transgenic I-E restricted to thymic medullary epithelium.

1993 • 76 citations

T cell receptor sequences from encephalitogenic T cells in adult Lewis rats suggest an early ontogenic origin.

1992 • 70 citations

Identification of rat Tcrb-V8.2, 8.5, and 10 gene products by monoclonal antibodies

1993 • 52 citations

Distribution and ultrastructure of S-100-immunoreactive cells in the human thymus

1984 • 45 citations

A Novel Transcript Overlapping the Myelin Basic Protein Gene

1992 • 43 citations

Detection by S-100 immunolabelling of interdigitating reticulum cells in human thymomas

1984 • 43 citations

Acetylcholine receptor—specific T‐Lymphocyte clones in the normal human immune repertoire: Target epitopes, hla restriction, and membrane phenotypes

1991 • 32 citations

A 16mer peptide of the human autoantigen calreticulin is a most prominent HLA-DR4Dw4-associated self-peptide

1994 • 31 citations

Long-term xenogeneic chimeras. Full differentiation of rat T and B cells in SCID mice.

1991 • 29 citations

Induction of experimental autoimmune encephalomyelitis in severe combined immunodeficient mice reconstituted with allogeneic or xenogeneic hematopoietic cells.

1993 • 25 citations

Encephalitogenic, myelin basic protein‐specific T cells from naive rat thymus: preferential use of the T cell receptor gene Vβ8.2 and expression of the CD4⁻ CD8⁻ phenotype

1995 • 21 citations

Recapitulation of normal and abnormal BB rat immune system development in scid mouse/rat lymphohemopoietic chimeras.

1991 • 14 citations

Encephalitogenic T lymphocytes develop from SJL/J hematopoietic cells transplanted into severe combined immimodeficient ( SCID) mice

1995 • 6 citations