Nitric oxide is a potential down-regulating molecule in autoimmune disease: inhibition of nitric oxide production renders PVG rats highly susceptible to EAE

Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production.

1988 • 2,865 citations

Role of nitric oxide synthesis in macrophage antimicrobial activity

1991 • 1,547 citations

Large Scale Preparation of Myelin Basic Protein from Central Nervous Tissue of Several Mammalian Species

1972 • 949 citations

Microglial cell cytotoxicity of oligodendrocytes is mediated through nitric oxide.

1993 • 782 citations

IFN-gamma plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis.

1996 • 642 citations

Aminoguanidine, a Novel Inhibitor of Nitric Oxide Formation, Prevents Diabetic Vascular Dysfunction

1992 • 609 citations

Interferon‐γ confers resistance to experimental allergic encephalomyelitis

1996 • 478 citations

Aminoguanidine, an inhibitor of inducible nitric oxide synthase, ameliorates experimental autoimmune encephalomyelitis in SJL mice.

1994 • 389 citations

Nitric oxide production is required for murine resident peritoneal macrophages to suppress mitogen-stimulated T cell proliferation. Role of IFN-gamma in the induction of the nitric oxide-synthesizing pathway.

1991 • 384 citations

Regulation of the immune response by nitric oxide differentially produced by T helper type 1 and T helper type 2 cells

1994 • 377 citations

In the rat, endogenous nitric oxide modulates the response of the hypothalamic-pituitary-adrenal axis to interleukin-1 beta, vasopressin, and oxytocin

1994 • 222 citations

The role of the neuroendocrine system in determining genetic susceptibility to experimental allergic encephalomyelitis in the rat.

1990 • 201 citations

Aminoguanidine, a novel inhibitor of nitric oxide formation, prevents diabetic vascular dysfunction

1992 • 192 citations

Local nitric oxide production in viral and autoimmune diseases of the central nervous system.

1995 • 185 citations

Role of nitric oxide in interleukin 2-induced corticotropin-releasing factor release from incubated hypothalami.

1993 • 184 citations

Expression of the inducible isoform of nitric oxide synthase in the central nervous system of mice correlates with the severity of actively induced experimental allergic encephalomyelitis

1995 • 181 citations

Possible role of nitric oxide in malarial immunosuppression

1994 • 167 citations

Effect of anti-interferon-γ and anti-interleukin-2 monoclonal antibody treatment on the development of actively and passively induced experimental allergic encephalomyelitis in the SJL/J mouse

1992 • 156 citations

Experimental allergic encephalomyelitis in the rat is inhibited by aminoguanidine, an inhibitor of nitric oxide synthase

1996 • 152 citations

Administration of nitric oxide synthase inhibitors in experimental autoimmune neuritis and experimental autoimmune encephalomyelitis

1995 • 144 citations

Interleukin-2 (IL-2) induces corticotropin-releasing factor (CRF) release from the amygdala and involves a nitric oxide-mediated signaling; comparison with the hypothalamic response.

1995 • 142 citations

Nitric oxide control of steroidogenesis: Endocrine effects of NG-nitro-L-arginine and comparisons to alcohol

1992 • 137 citations

Elevated secretion of reactive nitrogen and oxygen intermediates by inflammatory leukocytes in hyperacute experimental autoimmune encephalomyelitis: enhancement by the soluble products of encephalitogenic T cells.

1992 • 136 citations

Suppression of lymphocyte proliferation through the nitric oxide synthesizing pathway

1991 • 135 citations

Reactive nitrogen intermediates suppress the primary immunologic response to Listeria.

1993 • 130 citations

In vivo induction of nitrite and nitrate by tumor necrosis factor, lymphotoxin, and interleukin-1: possible roles in malaria

1992 • 129 citations

Aggravation of experimental allergic encephalomyelitis (EAE) by administration of nitric oxide (NO) synthase inhibitors

1996 • 124 citations

Effect of anti-interferon-γ monoclonal antibody treatment on the development of experimental allergic encephalomyelitis in resistant mouse strains

1994 • 122 citations

Aminoguanidine: A drug proposed for prophylaxis in diabetes inhibits catalase and generates hydrogen peroxide in vitro

1993 • 116 citations

Monoclonal Anti-Gamma Interferon Antibodies Enhance Experimental Allergic Encephalomyelitis

1993 • 115 citations

Cytokines and Murine Autoimmune Encephalomyelitis: Inhibition or Enhancement of Disease with Antibodies to Select Cytokines, or by Delivery of Exogenous Cytokines Using a Recombinant Vaccinia Virus System

1995 • 95 citations

Corticotropin-releasing factor, vasopressin, and prostaglandins mediate, and nitric oxide restrains, the hypothalamic-pituitary-adrenal response to acute local inflammation in the rat.

1996 • 94 citations

Suppression of Experimental Allergic Encephalomyelitis by Interferon

1982 • 71 citations

Involvement of nitric oxide in basal and interleukin-1β-induced CRH and ACTH release in vitro

1993 • 61 citations

Evidence for a role of nitric oxide in the corticotropin-releasing factor release induced by interleukin-1β

1995 • 58 citations

Experimental autoimmune encephalomyelitis (EAE) in genetically resistant rats: PVG rats resist active induction of EAE but are susceptible to and can generate EAE effector T cell lines.

1982 • 50 citations

Differential regulation of cytokine production by nitric oxide.

1993 • 45 citations

The susceptibility of rat strains to experimental allergic encephalomyelitis.

1973 • 44 citations

Nitric oxide inhibits LPS-induced tumor necrosis factor synthesis in vitro and in vivo

1996 • 42 citations

Astrocytic hypertrophy: An important pathological feature of chronic experimental autoimmune encephalitis in aged rats

1993 • 41 citations

Nitric oxide synthase inhibitors enhance plasma levels of corticosterone and ACTH

1996 • 38 citations

Feedback suppression of staphylococcal enterotoxin-stimulated T-lymphocyte proliferation by macrophages through inductive nitric oxide synthesis

1992 • 37 citations

Preparation and characterization of Ng-mono-, di- and trimethylated arginines.

1977 • 34 citations

Corticotropin-releasing factor, vasopressin, and prostaglandins mediate, and nitric oxide restrains, the hypothalamic-pituitary-adrenal response to acute local inflammation in the rat

1996 • 26 citations

N G -モノ,ジ-およびトリメチル化アルギニンの調製と性質

1977 • 22 citations

A pharmacological study on the role of nitric oxide in the pathogenesis of experimental allergic encephalomyelitis

1996 • 21 citations