A case report: Immune responses and clinical course of the first human use of granulocyte/macrophage-colony-stimulating-factor-transduced autologous melanoma cells for immunotherapy

Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity.

1993 • 2,828 citations

Mutator phenotype may be required for multistage carcinogenesis.

1991 • 1,327 citations

The major acute phase reactants: C-reactive protein, serum amyloid P component and serum amyloid A protein

1994 • 1,030 citations

T cells and eosinophils in the pathogenesis of asthma

1992 • 585 citations

Microsatellite instability: marker of a mutator phenotype in cancer.

1994 • 552 citations

IL-10 inhibits human T cell proliferation and IL-2 production.

1992 • 491 citations

Prolongation of Survival in Metastatic Melanoma After Active Specific Immunotherapy With a New Polyvalent Melanoma Vaccine

1992 • 410 citations

Treatment of metastatic melanoma with an autologous tumor-cell vaccine: clinical and immunologic results in 64 patients.

1990 • 300 citations

Increasing Incidence of Cutaneous Melanoma in Queensland, Australia

1992 • 271 citations

Production of IL‐10 by melanoma cells: Examination of its role in immunosuppression mediated by melanoma

1994 • 248 citations

Expression of cytokine/growth factors and their receptors in human melanoma and melanocytes

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Lymphocyte subsets in the blood: a diagnostic window on the lymphoid

1990 • 192 citations

Immune cell populations in cutaneous delayed-type hypersensitivity.

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An analysis of a melanoma epidemic

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Evidence for in situ amplification of cytotoxic T-lymphocytes with antitumor activity in a human regressive melanoma.

1993 • 121 citations

INTRAGRAFT CYTOKINE PROFILE DURING HUMAN LIVER ALLOGRAFT REJECTION 1, 2

1992 • 116 citations

High efficiency gene transfer into primary human tumor explants without cell selection.

1993 • 116 citations

Characterization of a receptor for interleukin 5 on human eosinophils: variable expression and induction by granulocyte/macrophage colony-stimulating factor.

1990 • 104 citations

BLOOD AND GRAFT EOSINOPHILIA AS PREDICTORS OF REJECTION IN HUMAN LIVER TRANSPLANTATION

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HLA-DR-antigen-associated restriction of EBV-specific cytotoxic T-cell colonies

1984 • 90 citations

The Development of Gene Therapy for the Treatment of Cancer

1993 • 74 citations

EVIDENCE FOR A NONCLASSICAL PATHWAY OF GRAFT REJECTION INVOLVING INTERLEUKIN 5 AND EOSINOPHILS

1993 • 73 citations

Polyvalent melanoma cell vaccine induces delayed-type hypersensitivity and in vitro cellular immune response.

1994 • 71 citations

THE PROGNOSTIC VALUE OF THE EOSINOPHIL IN ACUTE RENAL ALLOGRAFT REJECTION

1986 • 70 citations

The eosinophil as an effector cell of the immune response during hepatic allograft rejection

1994 • 69 citations

THE IMPORTANCE OF EOSINOPHIL CELLS IN KIDNEY ALLOGRAFT REJECTION

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Analysis of true anti-hapten cytotoxic clones in limit dilution microcultures after correction for "anti-self" activity: precursor frequencies, Ly-2 and Thy-1 phenotype, specificity, and statistical methods.

1983 • 47 citations

Mismatch repair, somatic mutations, and the origins of cancer.

1995 • 45 citations

Frequency of cytotoxic T lymphocyte precursors (CTLp) interacting with autologous tumor via the T‐cell receptor: Limiting dilution analysis of specific CTLp in peripheral blood and tumor‐invaded lymph nodes of melanoma patients

1994 • 45 citations

Eosinophils in acute renal allograft rejection

1994 • 39 citations

Ultrastructural evidence of the mechanisms responsible for interleukin‐4‐activated rejection of a spontaneous murine adenocarcinoma

1993 • 36 citations

Detection of melanoma-reactive CD4+ HLA-class I-restricted cytotoxic T cell clones with long-term assay and pretreatment of targets with interferon-?

1993 • 35 citations

Eb virus‐associated nuclear antigen production and cell proliferation in adult peripheral blood leukocytes inoculated with the qimr‐wil strain of eb virus

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Karoushi--death by overwork in the immune system.

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Correlation of eosinophilia with clinical response in patients with advanced carcinoma treated with low-dose recombinant interleukin-2 and mitomycin C

1992 • 19 citations

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